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C2H2 type master regulator of conidiophore development brlA (Bristle A protein)

 BRLA_EMENI              Reviewed;         432 AA.
P10069; C8VUE5; Q5BEQ7;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
20-JUN-2018, entry version 117.
RecName: Full=C2H2 type master regulator of conidiophore development brlA {ECO:0000305};
AltName: Full=Bristle A protein {ECO:0000303|PubMed:5366214};
Name=brlA {ECO:0000303|PubMed:3293800}; ORFNames=AN0973;
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
194 / M139) (Aspergillus nidulans).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=227321;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=3293800; DOI=10.1016/0092-8674(88)90198-5;
Adams T.H., Boylan M.T., Timberlake W.E.;
"brlA is necessary and sufficient to direct conidiophore development
in Aspergillus nidulans.";
Cell 54:353-362(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9290249; DOI=10.1006/fgbi.1997.0982;
Kupfer D.M., Reece C.A., Clifton S.W., Roe B.A., Prade R.A.;
"Multicellular ascomycetous fungal genomes contain more than 8000
genes.";
Fungal Genet. Biol. 21:364-372(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=16372000; DOI=10.1038/nature04341;
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A.
fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).
[4]
GENOME REANNOTATION.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
"The 2008 update of the Aspergillus nidulans genome annotation: a
community effort.";
Fungal Genet. Biol. 46:S2-13(2009).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37, AND FUNCTION.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=8508769;
Prade R.A., Timberlake W.E.;
"The Aspergillus nidulans brlA regulatory locus consists of
overlapping transcription units that are individually required for
conidiophore development.";
EMBO J. 12:2439-2447(1993).
[6]
FUNCTION.
PubMed=5366214;
Clutterbuck A.J.;
"A mutational analysis of conidial development in Aspergillus
nidulans.";
Genetics 63:317-327(1969).
[7]
FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
PubMed=2823119; DOI=10.1128/MCB.7.9.3113;
Boylan M.T., Mirabito P.M., Willett C.E., Zimmerman C.R.,
Timberlake W.E.;
"Isolation and physical characterization of three essential
conidiation genes from Aspergillus nidulans.";
Mol. Cell. Biol. 7:3113-3118(1987).
[8]
FUNCTION, AND INDUCTION.
PubMed=2655931; DOI=10.1016/0092-8674(89)90800-3;
Mirabito P.M., Adams T.H., Timberlake W.E.;
"Interactions of three sequentially expressed genes control temporal
and spatial specificity in Aspergillus development.";
Cell 57:859-868(1989).
[9]
FUNCTION, MUTAGENESIS OF CYS-327 AND CYS-357, AND DOMAIN.
PubMed=2108321; DOI=10.1128/MCB.10.4.1815;
Adams T.H., Deising H., Timberlake W.E.;
"brlA requires both zinc fingers to induce development.";
Mol. Cell. Biol. 10:1815-1817(1990).
[10]
FUNCTION.
PubMed=2196567; DOI=10.1073/pnas.87.14.5405;
Adams T.H., Timberlake W.E.;
"Developmental repression of growth and gene expression in
Aspergillus.";
Proc. Natl. Acad. Sci. U.S.A. 87:5405-5409(1990).
[11]
FUNCTION.
PubMed=1901560; DOI=10.1016/0378-1119(91)90105-K;
Birse C.E., Clutterbuck A.J.;
"Isolation and developmentally regulated expression of an Aspergillus
nidulans phenol oxidase-encoding gene, ivoB.";
Gene 98:69-76(1991).
[12]
FUNCTION.
PubMed=2065971; DOI=10.1101/gad.5.7.1161;
Stringer M.A., Dean R.A., Sewall T.C., Timberlake W.E.;
"Rodletless, a new Aspergillus developmental mutant induced by
directed gene inactivation.";
Genes Dev. 5:1161-1171(1991).
[13]
INDUCTION.
PubMed=1508186; DOI=10.1128/MCB.12.9.3827;
Adams T.H., Hide W.A., Yager L.N., Lee B.N.;
"Isolation of a gene required for programmed initiation of development
by Aspergillus nidulans.";
Mol. Cell. Biol. 12:3827-3833(1992).
[14]
FUNCTION, AND DNA-BINDING.
PubMed=8417986;
Chang Y.C., Timberlake W.E.;
"Identification of Aspergillus brlA response elements (BREs) by
genetic selection in yeast.";
Genetics 133:29-38(1993).
[15]
FUNCTION.
PubMed=7704830;
Sewall T.C.;
"Cellular effects of misscheduled brlA, abaA, and wetA expression in
Aspergillus nidulans.";
Can. J. Microbiol. 40:1035-1042(1994).
[16]
INDUCTION.
PubMed=24587098; DOI=10.1371/journal.pone.0089883;
Park H.S., Nam T.Y., Han K.H., Kim S.C., Yu J.H.;
"VelC positively controls sexual development in Aspergillus
nidulans.";
PLoS ONE 9:E89883-E89883(2014).
-!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of
conidiophore development and conidium maturation (PubMed:8508769,
PubMed:5366214, PubMed:2823119, PubMed:2655931,
PubMed:2196567,PubMed:7704830). They act individually and together
to regulate their own expression and that of numerous other
sporulation-specific genes (PubMed:2823119, PubMed:2655931,
PubMed:2108321). Binds promoters of target genes at brlA response
elements (BREs) containing the conserved sequence 5'-
(C/A)(A/G)AGGG(G/A)-3' (PubMed:8417986). Controls the expression
of the conidiophore-specific phenol oxidase ivoB (PubMed:1901560).
Controls the expression of the hydrophobin rodA (PubMed:2065971).
Mediates the developmental switch from the indeterminate, apical
growth pattern of vegetative cells to the budding growth pattern
of conidiophores (PubMed:3293800). Expression of brlA leads to
activation of abaA, wetA and stuA, cessation of vegetative growth,
cellular vacuolization and spore formation.
{ECO:0000269|PubMed:1901560, ECO:0000269|PubMed:2065971,
ECO:0000269|PubMed:2108321, ECO:0000269|PubMed:2196567,
ECO:0000269|PubMed:2655931, ECO:0000269|PubMed:2823119,
ECO:0000269|PubMed:3293800, ECO:0000269|PubMed:5366214,
ECO:0000269|PubMed:7704830, ECO:0000269|PubMed:8417986,
ECO:0000269|PubMed:8508769}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- INDUCTION: Expression is induced during conidiation, after
conidiophore stalks had formed and had begun to vesiculate
(PubMed:2823119). Positively regulated by abaA (PubMed:2655931).
Negatively regulated by velC (PubMed:24587098). Expression is also
controlled by acoD (PubMed:1508186). {ECO:0000269|PubMed:1508186,
ECO:0000269|PubMed:24587098, ECO:0000269|PubMed:2655931,
ECO:0000269|PubMed:2823119}.
-!- DOMAIN: Both zinc fingers are required to induce development
(PubMed:2108321). {ECO:0000269|PubMed:2108321}.
-!- DISRUPTION PHENOTYPE: Prevents the formation of normal
conidiophores (PubMed:2823119). {ECO:0000269|PubMed:2823119}.
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EMBL; M20631; AAA33300.1; -; Genomic_DNA.
EMBL; AC000133; AAB48671.1; -; Genomic_DNA.
EMBL; AACD01000014; EAA66002.1; -; Genomic_DNA.
EMBL; S62606; AAB27149.1; -; Genomic_DNA.
EMBL; BN001308; CBF88417.1; -; Genomic_DNA.
PIR; A28913; A28913.
RefSeq; XP_658577.1; XM_653485.1.
ProteinModelPortal; P10069; -.
STRING; 162425.CADANIAP00001679; -.
PRIDE; P10069; -.
EnsemblFungi; CBF88417; CBF88417; ANIA_00973.
EnsemblFungi; EAA66002; EAA66002; AN0973.2.
GeneID; 2876748; -.
KEGG; ani:AN0973.2; -.
HOGENOM; HOG000203573; -.
InParanoid; P10069; -.
KO; K09465; -.
OMA; NPCLSRP; -.
OrthoDB; EOG092C1XV5; -.
Proteomes; UP000000560; Chromosome VIII.
Proteomes; UP000005890; Unassembled WGS sequence.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:DNA binding transcription factor activity; IDA:AspGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0001896; P:autolysis; IMP:AspGD.
GO; GO:0048315; P:conidium formation; IMP:AspGD.
GO; GO:0075307; P:positive regulation of conidium formation; IMP:AspGD.
GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IMP:AspGD.
GO; GO:0010913; P:regulation of sterigmatocystin biosynthetic process; IMP:AspGD.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:AspGD.
GO; GO:0042594; P:response to starvation; IEP:AspGD.
GO; GO:0000905; P:sporocarp development involved in asexual reproduction; IMP:AspGD.
GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
GO; GO:0045461; P:sterigmatocystin biosynthetic process; IMP:AspGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
SMART; SM00355; ZnF_C2H2; 2.
SUPFAM; SSF57667; SSF57667; 1.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
1: Evidence at protein level;
Activator; Complete proteome; Conidiation; DNA-binding; Metal-binding;
Nucleus; Reference proteome; Repeat; Sporulation; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 432 C2H2 type master regulator of
conidiophore development brlA.
/FTId=PRO_0000046869.
ZN_FING 320 344 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 350 375 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
MUTAGEN 327 327 C->S: Fails to induce either the asexual
reproductive pathway or the expression of
development-specific genes.
{ECO:0000269|PubMed:2108321}.
MUTAGEN 357 357 C->S: Fails to induce either the asexual
reproductive pathway or the expression of
development-specific genes.
{ECO:0000269|PubMed:2108321}.
SEQUENCE 432 AA; 47932 MW; CA93E6A21CD33E25 CRC64;
MRNQSSLSDR LTVEVDCSSL GSNECPSMTS SFSPLESPTP TPTSIYSQGS LESPGWHGAG
SLPNNTYERT PGSASMRSAF RLAGMASTES LGLPYGSMEG QERMPMPDFL SGYDENIEQL
WMPSEAPKSY DHVAQGLAYH QGMHQYPTMA RNTNNNYRHQ AAAYLPESTT NPCLSRSIFH
QPERVPSSMS SSMSMNNMLP WMNLGDSIAP QTIAPSQVGP VTPPPSYTDF PTSLSAFKQH
SPTTPIRSCS LGTGSGADTP LSRLSGGPCE YMDDFQPSPV YRDGFQRPHR VASRKMLRRQ
TSKQNLMLEN LPQVIKQVQF KCKEPGCNGR FKRQEHLKRH MKSHSKEKPH VCWVPGCHRA
FSRSDNLNAH YTKTHSKRGG RNRYVATLDE NSPDYDPEFR GQLTPDGRPI YGSKLDDPIP
GAGDMSLDGW DE


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