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CCA-adding enzyme (EC 2.7.7.72) (CCA tRNA nucleotidyltransferase) (tRNA CCA-pyrophosphorylase) (tRNA adenylyl-/cytidylyl- transferase) (tRNA nucleotidyltransferase) (tRNA-NT)

 F8DHC7_STREP            Unreviewed;       403 AA.
F8DHC7;
21-SEP-2011, integrated into UniProtKB/TrEMBL.
21-SEP-2011, sequence version 1.
27-SEP-2017, entry version 50.
RecName: Full=CCA-adding enzyme {ECO:0000256|HAMAP-Rule:MF_01263, ECO:0000256|SAAS:SAAS00711017};
EC=2.7.7.72 {ECO:0000256|HAMAP-Rule:MF_01263, ECO:0000256|SAAS:SAAS00711012};
AltName: Full=CCA tRNA nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_01263};
AltName: Full=tRNA CCA-pyrophosphorylase {ECO:0000256|HAMAP-Rule:MF_01263};
AltName: Full=tRNA adenylyl-/cytidylyl- transferase {ECO:0000256|HAMAP-Rule:MF_01263};
AltName: Full=tRNA nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_01263};
AltName: Full=tRNA-NT {ECO:0000256|HAMAP-Rule:MF_01263};
Name=cca {ECO:0000256|HAMAP-Rule:MF_01263};
OrderedLocusNames=HMPREF0833_10586 {ECO:0000313|EMBL:AEH55617.1};
Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372
/ LMG 14537).
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Streptococcus.
NCBI_TaxID=760570 {ECO:0000313|EMBL:AEH55617.1, ECO:0000313|Proteomes:UP000001502};
[1] {ECO:0000313|Proteomes:UP000001502}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537
{ECO:0000313|Proteomes:UP000001502};
Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G.,
Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W.,
Liu X., Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J.,
Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D.,
Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A.,
Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L.,
Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.,
Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
Petrosino J., Highlander S., Gibbs R.;
"Complete sequence of Streptococcus parasanguinis strain ATCC 15912.";
Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the addition and repair of the essential 3'-
terminal CCA sequence in tRNAs without using a nucleic acid
template. Adds these three nucleotides in the order of C, C, and A
to the tRNA nucleotide-73, using CTP and ATP as substrates and
producing inorganic pyrophosphate. {ECO:0000256|HAMAP-
Rule:MF_01263, ECO:0000256|SAAS:SAAS00711016}.
-!- CATALYTIC ACTIVITY: A tRNA precursor + 2 CTP + ATP = a tRNA with a
3' CCA end + 3 diphosphate. {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00415332}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00711023};
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00711020}.
-!- MISCELLANEOUS: A single active site specifically recognizes both
ATP and CTP and is responsible for their addition.
{ECO:0000256|HAMAP-Rule:MF_01263}.
-!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
{ECO:0000256|HAMAP-Rule:MF_01263, ECO:0000256|SAAS:SAAS00711010}.
-----------------------------------------------------------------------
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EMBL; CP002843; AEH55617.1; -; Genomic_DNA.
RefSeq; WP_013903641.1; NC_015678.1.
ProteinModelPortal; F8DHC7; -.
EnsemblBacteria; AEH55617; AEH55617; HMPREF0833_10586.
GeneID; 10835085; -.
KEGG; scp:HMPREF0833_10586; -.
KO; K00974; -.
Proteomes; UP000001502; Chromosome.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0052929; F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0052928; F:CTP:3'-cytidine-tRNA cytidylyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0052927; F:CTP:tRNA cytidylyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
GO; GO:0016437; F:tRNA cytidylyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0042245; P:RNA repair; IEA:UniProtKB-KW.
GO; GO:0001680; P:tRNA 3'-terminal CCA addition; IEA:UniProtKB-UniRule.
CDD; cd05398; NT_ClassII-CCAase; 1.
HAMAP; MF_01263; CCA_bact_type3; 1.
InterPro; IPR032810; CCA-adding_enz_C.
InterPro; IPR023068; CCA-adding_enz_firmicutes.
InterPro; IPR002646; PolA_pol_head_dom.
InterPro; IPR032828; PolyA_RNA-bd.
Pfam; PF01743; PolyA_pol; 1.
Pfam; PF12627; PolyA_pol_RNAbd; 1.
Pfam; PF13735; tRNA_NucTran2_2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00415369};
Complete proteome {ECO:0000313|Proteomes:UP000001502};
Magnesium {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00711018};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00711009};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00415369};
Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00415426, ECO:0000313|EMBL:AEH55617.1};
RNA repair {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00711011};
RNA-binding {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00415356};
Transferase {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00415426, ECO:0000313|EMBL:AEH55617.1};
tRNA processing {ECO:0000256|HAMAP-Rule:MF_01263,
ECO:0000256|SAAS:SAAS00711024}.
DOMAIN 27 147 PolyA_pol. {ECO:0000259|Pfam:PF01743}.
DOMAIN 174 233 PolyA_pol_RNAbd.
{ECO:0000259|Pfam:PF12627}.
DOMAIN 250 394 tRNA_NucTran2_2.
{ECO:0000259|Pfam:PF13735}.
METAL 45 45 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_01263}.
METAL 47 47 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_01263}.
BINDING 32 32 ATP or CTP; via amide nitrogen.
{ECO:0000256|HAMAP-Rule:MF_01263}.
BINDING 35 35 ATP or CTP. {ECO:0000256|HAMAP-
Rule:MF_01263}.
BINDING 116 116 ATP or CTP. {ECO:0000256|HAMAP-
Rule:MF_01263}.
BINDING 159 159 ATP or CTP. {ECO:0000256|HAMAP-
Rule:MF_01263}.
BINDING 162 162 ATP or CTP. {ECO:0000256|HAMAP-
Rule:MF_01263}.
BINDING 165 165 ATP or CTP. {ECO:0000256|HAMAP-
Rule:MF_01263}.
BINDING 168 168 ATP or CTP. {ECO:0000256|HAMAP-
Rule:MF_01263}.
SEQUENCE 403 AA; 46427 MW; FE4A254E2C854706 CRC64;
MRLEKMPSEF QEALPILEKI KAAGFEAYFV GGSVRDALLD RPIHDVDIAS SSYPEETKAI
FDRTVDIGIE HGTVLVLENG QEYEITTFRT EDVYVDYRRP SSVSFVRSLE EDLKRRDFTV
NAFALNEKGE IVDLFHGLED LENKVLRAVG LPHERFNEDA LRIMRGFRFQ ASLGFELEEA
TSDAMKECAP LLEKISVERT FIEFDKLLLS PYWRQGVEAM LSSGAYHYLP EMKDRKEAIE
RLFDIELEYT FSTSEQAWAA LVLALEIQDI PKFFKKWKTS REFAKTVEQI VEILKLREKG
SLDKRACYKY EKRLLLLAEE LREGYALSVD YLVIERVYDS LTIHDKHEVV VNGGMLIKEY
GFQPGPALGE ILTKIEYAIV DGELANEKEA IIAYIQQAKE EEK


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