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CCCTC-binding factor (CCCTC-binding factor (Zinc finger protein))

 Q08DH9_BOVIN            Unreviewed;       727 AA.
Q08DH9; F1MK31;
31-OCT-2006, integrated into UniProtKB/TrEMBL.
31-OCT-2006, sequence version 1.
25-OCT-2017, entry version 86.
SubName: Full=CCCTC-binding factor {ECO:0000313|Ensembl:ENSBTAP00000018279};
SubName: Full=CCCTC-binding factor (Zinc finger protein) {ECO:0000313|EMBL:AAI23742.1};
Name=CTCF {ECO:0000313|EMBL:AAI23742.1,
ECO:0000313|Ensembl:ENSBTAP00000018279};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI23742.1};
[1] {ECO:0000313|EMBL:AAI23742.1}
NUCLEOTIDE SEQUENCE.
STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI23742.1};
TISSUE=Thalamus {ECO:0000313|EMBL:AAI23742.1};
Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
Siddiqui A., Holt R., Jones S.J., Marra M.A.;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSBTAP00000018279, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018279,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[3] {ECO:0000313|Ensembl:ENSBTAP00000018279}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018279};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
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EMBL; DAAA02046684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC123741; AAI23742.1; -; mRNA.
RefSeq; NP_001069216.1; NM_001075748.1.
RefSeq; XP_005218651.1; XM_005218594.3.
RefSeq; XP_005218653.1; XM_005218596.3.
RefSeq; XP_010812784.1; XM_010814482.2.
UniGene; Bt.39754; -.
STRING; 9913.ENSBTAP00000018279; -.
Ensembl; ENSBTAT00000018279; ENSBTAP00000018279; ENSBTAG00000013757.
GeneID; 517097; -.
KEGG; bta:517097; -.
CTD; 10664; -.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00890000139371; -.
HOGENOM; HOG000276534; -.
HOVERGEN; HBG000350; -.
OMA; EGEPMIC; -.
OrthoDB; EOG091G06B4; -.
TreeFam; TF106430; -.
Proteomes; UP000009136; Chromosome 18.
Bgee; ENSBTAG00000013757; -.
GO; GO:0000775; C:chromosome, centromeric region; IEA:Ensembl.
GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0043035; F:chromatin insulator sequence binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IEA:Ensembl.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0006306; P:DNA methylation; IEA:Ensembl.
GO; GO:0010216; P:maintenance of DNA methylation; IEA:Ensembl.
GO; GO:0016584; P:nucleosome positioning; IEA:Ensembl.
GO; GO:0071459; P:protein localization to chromosome, centromeric region; IEA:Ensembl.
GO; GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
GO; GO:0035065; P:regulation of histone acetylation; IEA:Ensembl.
GO; GO:0031060; P:regulation of histone methylation; IEA:Ensembl.
GO; GO:0040030; P:regulation of molecular function, epigenetic; IEA:Ensembl.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
SMART; SM00355; ZnF_C2H2; 11.
SUPFAM; SSF57667; SSF57667; 7.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
DOMAIN 266 293 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 294 321 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 322 350 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 351 378 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 379 406 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 407 435 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 437 465 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 467 494 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 495 522 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 523 546 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 555 573 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
SEQUENCE 727 AA; 82724 MW; F052C162F9942A92 CRC64;
MEGEAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV VQDVNSSVQM
VMMEQLDPTL LQMKTEVMEG AVAPEAEAAV DDTQIITLQV VNMEEQPINI GELQLVQVPV
PVTVPVATTS VEELQGAYEN EVSKEGLAES EPVICHTLPL PEGFQVVKVG ANGEVETLEQ
GELPPQEDPS WQKDPDYQPP AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV
NAEKVVGNMK PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP FKCSMCDYAS
VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT HSGEKPYECY ICHARFTQSG
TMKMHILQKH TENVAKFHCP HCDTVIARKS DLGVHLRKQH SYIEQGKKCR YCDAVFHERY
ALIQHQKSHK NEKRFKCDQC DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM
HFKRYHDPNF VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR
KMRSKKEDSS DSENAEPDLD DNEDEEEPAV EIEPEPEPQP VTPAPPPAKK RRGRPPGRTN
QPKQTQPTAI IQVEDQNTGA IENIIVEVKK EPDAEPAEGE EEEAQPAATD APNGDLTPEM
ILSMMDR


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