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CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166)

 CD166_RAT               Reviewed;         583 AA.
O35112; O55172;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
05-DEC-2018, entry version 120.
RecName: Full=CD166 antigen;
AltName: Full=Activated leukocyte cell adhesion molecule;
AltName: Full=HB2 {ECO:0000303|PubMed:9201982};
AltName: Full=KG-CAM {ECO:0000303|PubMed:8004458};
AltName: Full=Protein MEMD;
AltName: Full=SB-10 antigen {ECO:0000303|PubMed:9556065};
AltName: CD_antigen=CD166;
Flags: Precursor;
Name=Alcam;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=9201982; DOI=10.1074/jbc.272.27.16778;
Matsumoto A., Mitchell A., Kurata H., Pyle L., Kondo K., Itakura H.,
Fidge N.;
"Cloning and characterization of HB2, a candidate high density
lipoprotein receptor. Sequence homology with members of the
immunoglobulin superfamily of membrane proteins.";
J. Biol. Chem. 272:16778-16782(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 29-38.
PubMed=8004458; DOI=10.1016/0006-8993(94)91885-6;
Peduzzi J.D., Irwin M.H., Geisert E.E. Jr.;
"Distribution and characteristics of a 90 kDa protein, KG-CAM, in the
rat CNS.";
Brain Res. 640:296-307(1994).
[4]
PROTEIN SEQUENCE OF 45-55; 58-71; 77-87; 111-129; 143-152; 154-160;
176-189; 306-312 AND 406-423, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=Sprague-Dawley; TISSUE=Brain;
Lubec G., Kang S.U., Lubec S.;
Submitted (SEP-2007) to UniProtKB.
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 94-156 AND 270-361.
TISSUE=Mesenchymal cell;
PubMed=9556065; DOI=10.1359/jbmr.1998.13.4.655;
Bruder S.P., Ricalton N.S., Boynton R.E., Connolly T.J., Jaiswal N.,
Zaia J., Barry F.P.;
"Mesenchymal stem cell surface antigen SB-10 corresponds to activated
leukocyte cell adhesion molecule and is involved in osteogenic
differentiation.";
J. Bone Miner. Res. 13:655-663(1998).
[6]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-167, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=24090084; DOI=10.1021/pr400783j;
Parker B.L., Thaysen-Andersen M., Solis N., Scott N.E., Larsen M.R.,
Graham M.E., Packer N.H., Cordwell S.J.;
"Site-specific glycan-peptide analysis for determination of N-
glycoproteome heterogeneity.";
J. Proteome Res. 12:5791-5800(2013).
-!- FUNCTION: Cell adhesion molecule that mediates both heterotypic
cell-cell contacts via its interaction with CD6, as well as
homotypic cell-cell contacts. Promotes T-cell activation and
proliferation via its interactions with CD6 (By similarity).
Contributes to the formation and maturation of the immunological
synapse via its interactions with CD6 (By similarity). Mediates
homotypic interactions with cells that express ALCAM. Mediates
attachment of dendritic cells onto endothelial cells via homotypic
interaction. Inhibits endothelial cell migration and promotes
endothelial tube formation via homotypic interactions. Required
for normal organization of the lymph vessel network. Required for
normal hematopoietic stem cell engraftment in the bone marrow.
Plays a role in hematopoiesis; required for normal numbers of
hematopoietic stem cells in bone marrow. Promotes in vitro
osteoblast proliferation and differentiation (By similarity).
Promotes neurite extension, axon growth and axon guidance; axons
grow preferentially on surfaces that contain ALCAM (By
similarity). Mediates outgrowth and pathfinding for retinal
ganglion cell axons (By similarity).
{ECO:0000250|UniProtKB:P42292, ECO:0000250|UniProtKB:Q13740,
ECO:0000250|UniProtKB:Q61490}.
-!- SUBUNIT: Homodimer. Interacts (via extracellular domain) with CD6
(via extracellular domain). Homodimerization and interaction with
CD6 involve the same region and cannot occur simultaneously. The
affinity for CD6 is much higher than the affinity for self-
association. Interacts (via glycosylated extracellular domain)
with LGALS1 and LGALS3. Interaction with LGALS1 or LGALS3 inhibits
interaction with CD6. {ECO:0000250|UniProtKB:Q13740}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q61490}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:Q61490}. Cell projection, axon
{ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite
{ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological
synapse, i.e, at the contact zone between antigen-presenting
dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3
complex at the immunological synapse.
{ECO:0000250|UniProtKB:Q13740}.
-!- TISSUE SPECIFICITY: Strongest expression in the lung, then brain,
liver, and kidney. Present in the somatosensory system, basal
ganglia, cortex, olfactory system, and circumventricular organs.
-!- DOMAIN: The CD6 binding site is located in the N-terminal Ig-like
domain. {ECO:0000250|UniProtKB:Q13740}.
-!- PTM: The N-terminus is blocked.
-!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q13740}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB008538; BAA23279.1; -; mRNA.
EMBL; BC061970; AAH61970.1; -; mRNA.
EMBL; Y13240; CAA73692.1; -; mRNA.
EMBL; Y13241; CAA73693.1; -; mRNA.
RefSeq; NP_113941.1; NM_031753.1.
UniGene; Rn.5789; -.
ProteinModelPortal; O35112; -.
STRING; 10116.ENSRNOP00000002738; -.
SwissPalm; O35112; -.
UniCarbKB; O35112; -.
PaxDb; O35112; -.
PRIDE; O35112; -.
Ensembl; ENSRNOT00000002738; ENSRNOP00000002738; ENSRNOG00000001989.
GeneID; 79559; -.
KEGG; rno:79559; -.
UCSC; RGD:619972; rat.
CTD; 214; -.
RGD; 619972; Alcam.
eggNOG; ENOG410IFQ2; Eukaryota.
eggNOG; ENOG410ZWU9; LUCA.
GeneTree; ENSGT00940000156881; -.
HOGENOM; HOG000070101; -.
HOVERGEN; HBG050847; -.
InParanoid; O35112; -.
KO; K06547; -.
OMA; QKTVHSE; -.
OrthoDB; EOG091G04XY; -.
PhylomeDB; O35112; -.
TreeFam; TF321859; -.
PRO; PR:O35112; -.
Proteomes; UP000002494; Chromosome 11.
Bgee; ENSRNOG00000001989; Expressed in 9 organ(s), highest expression level in lung.
Genevisible; O35112; RN.
GO; GO:0030424; C:axon; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0042101; C:T cell receptor complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0048846; P:axon extension involved in axon guidance; ISS:UniProtKB.
GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:UniProtKB.
GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
GO; GO:1990138; P:neuron projection extension; ISS:UniProtKB.
GO; GO:0031290; P:retinal ganglion cell axon guidance; ISS:UniProtKB.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR039810; CD166_antigen.
InterPro; IPR013162; CD80_C2-set.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
PANTHER; PTHR11973:SF2; PTHR11973:SF2; 1.
Pfam; PF08205; C2-set_2; 1.
SMART; SM00409; IG; 3.
SUPFAM; SSF48726; SSF48726; 4.
PROSITE; PS50835; IG_LIKE; 4.
1: Evidence at protein level;
Adaptive immunity; Cell adhesion; Cell membrane; Cell projection;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 27 {ECO:0000255}.
CHAIN 28 583 CD166 antigen.
/FTId=PRO_0000014661.
TOPO_DOM 28 527 Extracellular. {ECO:0000255}.
TRANSMEM 528 549 Helical. {ECO:0000255}.
TOPO_DOM 550 583 Cytoplasmic. {ECO:0000255}.
DOMAIN 28 120 Ig-like V-type 1.
DOMAIN 125 234 Ig-like V-type 2.
DOMAIN 245 328 Ig-like C2-type 1.
DOMAIN 333 409 Ig-like C2-type 2.
DOMAIN 416 501 Ig-like C2-type 3.
CARBOHYD 95 95 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 167 167 N-linked (GlcNAc...) asparagine.
{ECO:0000244|PubMed:24090084}.
CARBOHYD 265 265 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 306 306 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 361 361 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 457 457 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 480 480 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 499 499 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 43 113 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 157 220 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 270 313 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 354 392 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 435 485 {ECO:0000255|PROSITE-ProRule:PRU00114}.
CONFLICT 339 339 S -> G (in Ref. 5; CAA73693).
{ECO:0000305}.
SEQUENCE 583 AA; 65022 MW; D36B73854F5DF61E CRC64;
MASKGSPSCR LVFCLLISAA VLRPGLGWYT VNSAYGDTIV MPCRLDVPQN LMFGKWKYEK
PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL SLSENYTLSI NNAKISDEKR FVCMLVTEDN
VFEAPTLVKV FKQPSKPEIV NRAAFLETEQ LKKLGDCISR DSYPDGNITW YRNGKVLQPV
DGEVSILFKK EIDPGTQLYT MTSSLEYKTT KSDIQMPFTC SVTYYGPSGQ KTIYSEQAIF
DIYYPTEQVT IQVLPPKNAI KEGDNITLQC LGNGNPPPEE FMFYLPGQAE GIRSSNTYTL
TDVRRNATGD YKCSLIDQRN MAASTTITVH YLDLSLNPSG EVTKQIGDTL PVSCTISASR
NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM
TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN
VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADDISDENRE KVNDQAKLIV GIVVGLLLAA
LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA


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