GENTAUR Molecular Products.

 CD177_HUMAN             Reviewed;         437 AA.
 Q8N6Q3; Q711Q2; Q8NCV9; Q96QH1; Q9HDA5;
 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
 04-APR-2006, sequence version 2.
 20-JUN-2018, entry version 112.
 RecName: Full=CD177 antigen {ECO:0000312|HGNC:HGNC:30072};
 AltName: Full=Human neutrophil alloantigen 2a {ECO:0000305|PubMed:11465086};
          Short=HNA-2a {ECO:0000305|PubMed:11465086};
 AltName: Full=NB1 glycoprotein {ECO:0000305|PubMed:11465086};
          Short=NB1 GP {ECO:0000305|PubMed:11465086};
 AltName: Full=Polycythemia rubra vera protein 1 {ECO:0000303|PubMed:10753836};
          Short=PRV-1 {ECO:0000303|PubMed:10753836};
 AltName: CD_antigen=CD177;
 Flags: Precursor;
 Name=CD177 {ECO:0000312|HGNC:HGNC:30072};
 Synonyms=NB1, PRV1 {ECO:0000303|PubMed:10753836};
 ORFNames=UNQ595/PRO1181;
 Homo sapiens (Human).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Hominidae; Homo.
 NCBI_TaxID=9606;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-251, TISSUE
 SPECIFICITY, AND INDUCTION.
 PubMed=10753836;
 Temerinac S., Klippel S., Strunck E., Roeder S., Luebbert M.,
 Lange W., Azemar M., Meinhardt G., Schaefer H.-E., Pahl H.L.;
 "Cloning of PRV-1, a novel member of the uPAR receptor superfamily,
 which is overexpressed in polycythemia rubra vera.";
 Blood 95:2569-2576(2000).
 [2]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 35-45;
 167-175 AND 386-393, VARIANTS PRO-3; PHE-119; ILE-251; GLN-323 AND
 SER-379, MASS SPECTROMETRY, AND GLYCOSYLATION.
 PubMed=11465086;
 DOI=10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J;
 Kissel K., Santoso S., Hofmann C., Stroncek D., Bux J.;
 "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved
 in the pathogenesis of immunenneutropenia and transfusion reactions.";
 Eur. J. Immunol. 31:1301-1309(2001).
 [3]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), AND VARIANT PRO-3.
 PubMed=12010833; DOI=10.1182/blood.V99.11.4231;
 Kissel K., Scheffler S., Kerowgan M., Bux J.;
 "Molecular basis of NB1 (HNA-2a, CD177) deficiency.";
 Blood 99:4231-4233(2002).
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
 ILE-251.
 PubMed=12975309; DOI=10.1101/gr.1293003;
 Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
 Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
 Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
 Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
 Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
 Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
 Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
 Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
 Wood W.I., Godowski P.J., Gray A.M.;
 "The secreted protein discovery initiative (SPDI), a large-scale
 effort to identify novel human secreted and transmembrane proteins: a
 bioinformatics assessment.";
 Genome Res. 13:2265-2270(2003).
 [5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
 ILE-251.
 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
 Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
 Phelan M., Farmer A.;
 "Cloning of human full-length CDSs in BD Creator(TM) system donor
 vector.";
 Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
 [6]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PRO-3
 AND THR-348.
 TISSUE=Colon;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 [7]
 PROTEIN SEQUENCE OF 22-36.
 PubMed=15340161; DOI=10.1110/ps.04682504;
 Zhang Z., Henzel W.J.;
 "Signal peptide prediction based on analysis of experimentally
 verified cleavage sites.";
 Protein Sci. 13:2819-2824(2004).
 [8]
 SUBCELLULAR LOCATION, GLYCOSYLATION, AND SHEDDING.
 PubMed=12239154; DOI=10.1182/blood-2002-03-0949;
 Klippel S., Strunck E., Busse C.E., Behringer D., Pahl H.L.;
 "Biochemical characterization of PRV-1, a novel hematopoietic cell
 surface receptor, which is overexpressed in polycythemia rubra vera.";
 Blood 100:2441-2448(2002).
 [9]
 INDUCTION, AND TISSUE SPECIFICITY.
 PubMed=12377969; DOI=10.1200/JCO.2002.11.507;
 Teofili L., Martini M., Luongo M., Di Mario A., Leone G.,
 De Stefano V., Larocca L.M.;
 "Overexpression of the polycythemia rubra vera-1 gene in essential
 thrombocythemia.";
 J. Clin. Oncol. 20:4249-4254(2002).
 [10]
 SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
 PubMed=12675722;
 Caruccio L., Bettinotti M., Matsuo K., Sharon V., Stroncek D.;
 "Expression of human neutrophil antigen-2a (NB1) is increased in
 pregnancy.";
 Transfusion 43:357-363(2003).
 [11]
 FUNCTION, INTERACTION WITH PRTN3, SUBCELLULAR LOCATION, TISSUE
 SPECIFICITY, AND INDUCTION.
 PubMed=17244676; DOI=10.1182/blood-2006-10-055327;
 von Vietinghoff S., Tunnemann G., Eulenberg C., Wellner M.,
 Cristina Cardoso M., Luft F.C., Kettritz R.;
 "NB1 mediates surface expression of the ANCA antigen proteinase 3 on
 human neutrophils.";
 Blood 109:4487-4493(2007).
 [12]
 FUNCTION, INTERACTION WITH PECAM1, SUBCELLULAR LOCATION, AND TISSUE
 SPECIFICITY.
 PubMed=17580308; DOI=10.1074/jbc.M701120200;
 Sachs U.J., Andrei-Selmer C.L., Maniar A., Weiss T., Paddock C.,
 Orlova V.V., Choi E.Y., Newman P.J., Preissner K.T., Chavakis T.,
 Santoso S.;
 "The neutrophil-specific antigen CD177 is a counter-receptor for
 platelet endothelial cell adhesion molecule-1 (CD31).";
 J. Biol. Chem. 282:23603-23612(2007).
 [13]
 FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL
 STAGE, AND INDUCTION.
 PubMed=18462208; DOI=10.1111/j.1365-2249.2008.03663.x;
 von Vietinghoff S., Eulenberg C., Wellner M., Luft F.C., Kettritz R.;
 "Neutrophil surface presentation of the anti-neutrophil cytoplasmic
 antibody-antigen proteinase 3 depends on N-terminal processing.";
 Clin. Exp. Immunol. 152:508-516(2008).
 [14]
 FUNCTION, IDENTIFICATION IN A COMPLEX WITH ITGAM AND ITGB2,
 SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
 PubMed=21193407; DOI=10.1074/jbc.M110.171256;
 Jerke U., Rolle S., Dittmar G., Bayat B., Santoso S., Sporbert A.,
 Luft F., Kettritz R.;
 "Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-
 ANCA neutrophil activation.";
 J. Biol. Chem. 286:7070-7081(2011).
 [15]
 FUNCTION.
 PubMed=23202369; DOI=10.1161/ATVBAHA.112.300474;
 Kuckleburg C.J., Newman P.J.;
 "Neutrophil proteinase 3 acts on protease-activated receptor-2 to
 enhance vascular endothelial cell barrier function.";
 Arterioscler. Thromb. Vasc. Biol. 33:275-284(2013).
 [16]
 FUNCTION.
 PubMed=23461681; DOI=10.1111/ejh.12095;
 Wang L., Ge S., Agustian A., Hiss M., Haller H., von Vietinghoff S.;
 "Surface receptor CD177/NB1 does not confer a recruitment advantage to
 neutrophilic granulocytes during human peritonitis.";
 Eur. J. Haematol. 90:436-437(2013).
 [17]
 SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
 PubMed=24926686; DOI=10.1371/journal.pone.0099671;
 Hu N., Mora-Jensen H., Theilgaard-Moench K., Doornbos-van der Meer B.,
 Huitema M.G., Stegeman C.A., Heeringa P., Kallenberg C.G., Westra J.;
 "Differential expression of granulopoiesis related genes in neutrophil
 subsets distinguished by membrane expression of CD177.";
 PLoS ONE 9:E99671-E99671(2014).
 [18]
 FUNCTION, IDENTIFICATION IN A COMPLEX WITH ITGAM AND ITGB2,
 SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
 PubMed=28807980; DOI=10.1182/blood-2017-03-768507;
 Bai M., Grieshaber-Bouyer R., Wang J., Schmider A.B., Wilson Z.S.,
 Zeng L., Halyabar O., Godin M.D., Nguyen H.N., Levescot A., Cunin P.,
 Lefort C.T., Soberman R.J., Nigrovic P.A.;
 "CD177 modulates human neutrophil migration through activation-
 mediated integrin and chemoreceptor regulation.";
 Blood 130:2092-2100(2017).
 [19]
 INTERACTION WITH PRTN3, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
 PubMed=28240246; DOI=10.1038/srep43328;
 Jerke U., Marino S.F., Daumke O., Kettritz R.;
 "Characterization of the CD177 interaction with the ANCA antigen
 proteinase 3.";
 Sci. Rep. 7:43328-43328(2017).
 [20]
 VARIANT THR-348, AND POLYMORPHISM.
 PubMed=12623849; DOI=10.1182/blood-2002-09-2831;
 Wolff J., Brendel C., Fink L., Bohle R.M., Kissel K., Bux J.;
 "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP-
 neutrophils from NB1 GP-expressing individuals and association of low
 expression with NB1 gene polymorphisms.";
 Blood 102:731-733(2003).
 [21]
 VARIANTS PRO-3; PHE-119; GLN-323 AND SER-379, AND POLYMORPHISM.
 PubMed=14692971; DOI=10.1046/j.0041-1132.2004.00606.x;
 Caruccio L., Walkovich K., Bettinotti M., Schuller R., Stroncek D.;
 "CD177 polymorphisms: correlation between high-frequency single
 nucleotide polymorphisms and neutrophil surface protein expression.";
 Transfusion 44:77-82(2004).
 [22]
 VARIANTS PRO-3; LEU-31; ILE-251; ALA-261; THR-348 AND ARG-431,
 SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND POLYMORPHISM.
 PubMed=27227454; DOI=10.1371/journal.pgen.1006067;
 Wu Z., Liang R., Ohnesorg T., Cho V., Lam W., Abhayaratna W.P.,
 Gatenby P.A., Perera C., Zhang Y., Whittle B., Sinclair A.,
 Goodnow C.C., Field M., Andrews T.D., Cook M.C.;
 "Heterogeneity of human neutrophil CD177 expression results from
 CD177P1 pseudogene conversion.";
 PLoS Genet. 12:E1006067-E1006067(2016).
 -!- FUNCTION: In association with beta-2 integrin heterodimer
     ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha
     primed neutrophils including degranulation and superoxide
     production (PubMed:21193407). In addition, by preventing beta-2
     integrin internalization and attenuating chemokine signaling
     favors adhesion over migration (PubMed:28807980). Heterophilic
     interaction with PECAM1 on endothelial cells plays a role in
     neutrophil transendothelial migration in vitro (PubMed:17580308).
     However, appears to be dispensable for neutrophil recruitment
     caused by bacterial infection in vivo (PubMed:23461681). Acts as a
     receptor for the mature form of protease PRTN3 allowing its
     display at the cell surface of neutrophils (PubMed:17244676,
     PubMed:18462208). By displaying PRTN3 at the neutrophil cell
     surface, may play a role in enhancing endothelial cell junctional
     integrity and thus vascular integrity during neutrophil diapedesis
     (PubMed:23202369). {ECO:0000269|PubMed:17244676,
     ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208,
     ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23202369,
     ECO:0000269|PubMed:23461681, ECO:0000269|PubMed:28807980}.
 -!- SUBUNIT: Found in a complex with integrin ITGAM/CD11b and
     ITGB2/CD18 (PubMed:28807980, PubMed:21193407). Interacts with
     PECAM1 (via Ig-like C2-type domain 6); the interaction is Ca(2+)-
     dependent; the interaction is direct (PubMed:17580308). Interacts
     with serine protease PRTN3/myeloblastin; the interaction tethers
     PRTN3 to the cell surface; the interaction is direct
     (PubMed:17244676, PubMed:28240246). {ECO:0000269|PubMed:17244676,
     ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:21193407,
     ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:28807980}.
 -!- INTERACTION:
     Q9Y2W7:KCNIP3; NbExp=6; IntAct=EBI-747170, EBI-751501;
 -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12239154,
     ECO:0000269|PubMed:12675722, ECO:0000269|PubMed:17244676,
     ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208,
     ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:24926686,
     ECO:0000269|PubMed:27227454, ECO:0000269|PubMed:28240246,
     ECO:0000269|PubMed:28807980}; Lipid-anchor, GPI-anchor
     {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676}.
     Membrane raft {ECO:0000269|PubMed:21193407}; Lipid-anchor, GPI-
     like-anchor {ECO:0000269|PubMed:12239154,
     ECO:0000269|PubMed:17244676}. Secreted
     {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:18462208}.
     Cytoplasmic granule membrane {ECO:0000269|PubMed:18462208}. Cell
     projection, lamellipodium {ECO:0000269|PubMed:28807980}. Note=Cell
     surface expression on neutrophils is increased upon TNF-alpha,
     fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676,
     PubMed:17580308). In neutrophils, stored predominantly in
     secondary and tertiary granules (PubMed:18462208). Can also be
     shedded from the cell membrane (PubMed:12239154, PubMed:18462208).
     Localizes to lamellar protrusions in spreading neutrophils
     (PubMed:28807980). {ECO:0000269|PubMed:12239154,
     ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308,
     ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28807980}.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=3;
     Name=1;
       IsoId=Q8N6Q3-1; Sequence=Displayed;
     Name=2;
       IsoId=Q8N6Q3-2; Sequence=VSP_017860, VSP_017861;
       Note=Associated with CD177-negative phenotype.;
     Name=3;
       IsoId=Q8N6Q3-3; Sequence=VSP_017858, VSP_017859;
       Note=Associated with CD177-negative phenotype.;
 -!- TISSUE SPECIFICITY: Highly expressed in normal bone marrow and
     weakly expressed in fetal liver (PubMed:10753836). During
     neutrophil differentiation, expression begins at the metamyelocyte
     stage and continues throughout the subsequent stages (at protein
     level) (PubMed:17244676, PubMed:18462208, PubMed:24926686).
     Expressed by a subset of mature neutrophils (at protein level)
     (PubMed:10753836, PubMed:28240246, PubMed:12377969,
     PubMed:18462208, PubMed:12675722, PubMed:17244676,
     PubMed:17580308, PubMed:21193407, PubMed:24926686,
     PubMed:28807980, PubMed:27227454). The percentage of neutrophils
     expressing CD177 varies across the population (PubMed:17244676,
     PubMed:27227454). Expressed in granulocytes of patients with
     polycythemia vera (PV) and with essential thrombocythemia (ET)
     (PubMed:10753836, PubMed:12377969). {ECO:0000269|PubMed:10753836,
     ECO:0000269|PubMed:12377969, ECO:0000269|PubMed:12675722,
     ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308,
     ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407,
     ECO:0000269|PubMed:27227454, ECO:0000269|PubMed:28240246,
     ECO:0000269|PubMed:28807980}.
 -!- DEVELOPMENTAL STAGE: Expressed in neonatal and adult neutrophils.
     {ECO:0000269|PubMed:18462208}.
 -!- INDUCTION: By CSF3/G-CSF in resting granulocytes
     (PubMed:10753836). Induced during CSF3/G-CSF-mediated neutrophil
     differentiation (PubMed:17244676, PubMed:18462208). Induced during
     pregnancy (PubMed:12675722). Induced in patients with polycythemia
     vera (PV) and with essential thrombocythemia (ET)
     (PubMed:10753836, PubMed:12377969). {ECO:0000269|PubMed:10753836,
     ECO:0000269|PubMed:12377969, ECO:0000269|PubMed:12675722,
     ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208}.
 -!- PTM: N-glycosylated. {ECO:0000269|PubMed:11465086,
     ECO:0000269|PubMed:12239154}.
 -!- PTM: A soluble form may also be produced by proteolytic cleavage
     at the cell surface (shedding). {ECO:0000269|PubMed:12239154,
     ECO:0000269|PubMed:18462208}.
 -!- MASS SPECTROMETRY: Mass=50556; Method=MALDI; Range=22-408;
     Evidence={ECO:0000269|PubMed:11465086};
 -!- POLYMORPHISM: There is a significant association between the
     variants Ala-3, Leu-251 and Thr-348 and a low expression of CD177
     on neutrophils (PubMed:12623849, PubMed:14692971). Expression of
     CD177 on neutrophils is a trait determined by ratio of
     CD177/CD177P1 alleles (PubMed:27227454). The phenotype of CD177
     null neutrophils is due to recombination between exon 7 of CD177
     and the pseudogene CD177P1 through gene conversion, changing Lys-
     263 codon into stop codon (PubMed:27227454). The lack of CD177
     expression affects 1-10 percent of the population placing them at
     risk for formation of anti-neutrophil antibodies that can cause
     transfusion-related acute lung injury and neonatal alloimmune
     neutropenia. {ECO:0000269|PubMed:12623849,
     ECO:0000269|PubMed:14692971, ECO:0000269|PubMed:27227454}.
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 EMBL; AF146747; AAG00895.1; -; mRNA.
 EMBL; AJ290452; CAC44459.1; -; mRNA.
 EMBL; AJ305326; CAC83758.1; -; mRNA.
 EMBL; AJ310433; CAC83724.1; -; mRNA.
 EMBL; AY358932; AAQ89291.1; -; mRNA.
 EMBL; BT020111; AAV38914.1; -; mRNA.
 EMBL; BC029167; AAH29167.1; -; mRNA.
 CCDS; CCDS62700.1; -. [Q8N6Q3-1]
 RefSeq; NP_065139.2; NM_020406.3.
 UniGene; Hs.232165; -.
 ProteinModelPortal; Q8N6Q3; -.
 BioGrid; 121389; 3.
 IntAct; Q8N6Q3; 2.
 STRING; 9606.ENSP00000367248; -.
 BioMuta; CD177; -.
 DMDM; 91208246; -.
 PaxDb; Q8N6Q3; -.
 PeptideAtlas; Q8N6Q3; -.
 PRIDE; Q8N6Q3; -.
 ProteomicsDB; 72212; -.
 ProteomicsDB; 72213; -. [Q8N6Q3-2]
 ProteomicsDB; 72214; -. [Q8N6Q3-3]
 DNASU; 57126; -.
 Ensembl; ENST00000378012; ENSP00000367251; ENSG00000204936. [Q8N6Q3-3]
 GeneID; 57126; -.
 KEGG; hsa:57126; -.
 UCSC; uc060zla.1; human. [Q8N6Q3-1]
 CTD; 57126; -.
 DisGeNET; 57126; -.
 EuPathDB; HostDB:ENSG00000204936.9; -.
 GeneCards; CD177; -.
 H-InvDB; HIX0017865; -.
 HGNC; HGNC:30072; CD177.
 HPA; HPA041820; -.
 HPA; HPA046601; -.
 MIM; 162860; gene.
 neXtProt; NX_Q8N6Q3; -.
 OpenTargets; ENSG00000204936; -.
 PharmGKB; PA142672147; -.
 eggNOG; ENOG410J207; Eukaryota.
 eggNOG; ENOG4111D7X; LUCA.
 GeneTree; ENSGT00530000063351; -.
 HOVERGEN; HBG081064; -.
 InParanoid; Q8N6Q3; -.
 KO; K06552; -.
 PhylomeDB; Q8N6Q3; -.
 Reactome; R-HSA-140875; Common Pathway of Fibrin Clot Formation.
 Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
 Reactome; R-HSA-6798695; Neutrophil degranulation.
 GeneWiki; CD177; -.
 GenomeRNAi; 57126; -.
 PRO; PR:Q8N6Q3; -.
 Proteomes; UP000005640; Chromosome 19.
 Bgee; ENSG00000204936; -.
 CleanEx; HS_CD177; -.
 ExpressionAtlas; Q8N6Q3; baseline and differential.
 Genevisible; Q8N6Q3; HS.
 GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
 GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
 GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO; GO:0044853; C:plasma membrane raft; IDA:UniProtKB.
 GO; GO:0030667; C:secretory granule membrane; IDA:UniProtKB.
 GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
 GO; GO:0070821; C:tertiary granule membrane; IDA:UniProtKB.
 GO; GO:0048306; F:calcium-dependent protein binding; IPI:UniProtKB.
 GO; GO:0005178; F:integrin binding; IPI:UniProtKB.
 GO; GO:0002020; F:protease binding; IPI:UniProtKB.
 GO; GO:0007596; P:blood coagulation; TAS:Reactome.
 GO; GO:0007155; P:cell adhesion; IMP:UniProtKB.
 GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IMP:UniProtKB.
 GO; GO:0045217; P:cell-cell junction maintenance; IMP:UniProtKB.
 GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO; GO:0007159; P:leukocyte cell-cell adhesion; IMP:UniProtKB.
 GO; GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
 GO; GO:0072672; P:neutrophil extravasation; IMP:UniProtKB.
 GO; GO:1990266; P:neutrophil migration; IMP:UniProtKB.
 GO; GO:0043315; P:positive regulation of neutrophil degranulation; IGI:UniProtKB.
 GO; GO:0032930; P:positive regulation of superoxide anion generation; IGI:UniProtKB.
 GO; GO:0034394; P:protein localization to cell surface; IMP:UniProtKB.
 GO; GO:0030100; P:regulation of endocytosis; IDA:UniProtKB.
 GO; GO:2001044; P:regulation of integrin-mediated signaling pathway; IMP:UniProtKB.
 InterPro; IPR016054; LY6_UPA_recep-like.
 Pfam; PF00021; UPAR_LY6; 2.
 1: Evidence at protein level;
 Alternative splicing; Cell adhesion; Cell membrane; Cell projection;
 Complete proteome; Direct protein sequencing; Glycoprotein;
 GPI-anchor; Immunity; Innate immunity; Lipoprotein; Membrane;
 Polymorphism; Reference proteome; Repeat; Secreted; Signal.
 SIGNAL        1     21       {ECO:0000269|PubMed:15340161}.
 CHAIN        22    408       CD177 antigen.
                              /FTId=PRO_0000231643.
 PROPEP      409    437       Removed in mature form. {ECO:0000255}.
                              /FTId=PRO_0000231644.
 DOMAIN      133    210       UPAR/Ly6 1.
 DOMAIN      325    377       UPAR/Ly6 2.
 LIPID       408    408       GPI-anchor amidated glycine.
                              {ECO:0000255}.
 CARBOHYD    189    189       N-linked (GlcNAc...) asparagine.
                              {ECO:0000255}.
 VAR_SEQ     129    145       GSLRCPVCLSMEGCLEG -> MMGAAEGPFGKAEQVDS
                              (in isoform 3).
                              {ECO:0000303|PubMed:12010833}.
                              /FTId=VSP_017858.
 VAR_SEQ     146    437       Missing (in isoform 3).
                              {ECO:0000303|PubMed:12010833}.
                              /FTId=VSP_017859.
 VAR_SEQ     210    248       TCHRGTTIMTHGNLAQEPTDWTTSNTEMCEVGQVCQETL
                              -> QLKPVGLLEEHNVGEKERGQGQHQCVQLDWQKRAATGI
                              F (in isoform 2).
                              {ECO:0000303|PubMed:12010833}.
                              /FTId=VSP_017860.
 VAR_SEQ     249    437       Missing (in isoform 2).
                              {ECO:0000303|PubMed:12010833}.
                              /FTId=VSP_017861.
 VARIANT       3      3       A -> P (in dbSNP:rs45441892).
                              {ECO:0000269|PubMed:11465086,
                              ECO:0000269|PubMed:12010833,
                              ECO:0000269|PubMed:14692971,
                              ECO:0000269|PubMed:15489334,
                              ECO:0000269|PubMed:27227454}.
                              /FTId=VAR_025858.
 VARIANT      31     31       H -> L (in dbSNP:rs45553433).
                              {ECO:0000269|PubMed:27227454}.
                              /FTId=VAR_079754.
 VARIANT     119    119       L -> F. {ECO:0000269|PubMed:11465086,
                              ECO:0000269|PubMed:14692971}.
                              /FTId=VAR_026156.
 VARIANT     251    251       L -> I (in dbSNP:rs10425835).
                              {ECO:0000269|PubMed:10753836,
                              ECO:0000269|PubMed:11465086,
                              ECO:0000269|PubMed:12975309,
                              ECO:0000269|PubMed:27227454,
                              ECO:0000269|Ref.5}.
                              /FTId=VAR_025859.
 VARIANT     261    261       G -> A. {ECO:0000269|PubMed:27227454}.
                              /FTId=VAR_079755.
 VARIANT     323    323       R -> Q. {ECO:0000269|PubMed:11465086,
                              ECO:0000269|PubMed:14692971}.
                              /FTId=VAR_026157.
 VARIANT     348    348       A -> T (in dbSNP:rs17856829).
                              {ECO:0000269|PubMed:12623849,
                              ECO:0000269|PubMed:15489334,
                              ECO:0000269|PubMed:27227454}.
                              /FTId=VAR_025860.
 VARIANT     379    379       F -> S. {ECO:0000269|PubMed:11465086,
                              ECO:0000269|PubMed:14692971}.
                              /FTId=VAR_026158.
 VARIANT     431    431       G -> R (in dbSNP:rs78718189).
                              {ECO:0000269|PubMed:27227454}.
                              /FTId=VAR_079756.
 CONFLICT     89     89       H -> Y (in Ref. 3; CAC83724).
                              {ECO:0000305}.
 CONFLICT    184    184       G -> V (in Ref. 3; CAC83724).
                              {ECO:0000305}.
 CONFLICT    194    194       I -> F (in Ref. 3; CAC83724).
                              {ECO:0000305}.
 CONFLICT    204    205       NR -> DM (in Ref. 3; CAC83724).
                              {ECO:0000305}.
 SEQUENCE   437 AA;  46363 MW;  3D4716F221934910 CRC64;
 MSAVLLLALL GFILPLPGVQ ALLCQFGTVQ HVWKVSDLPR QWTPKNTSCD SGLGCQDTLM
 LIESGPQVSL VLSKGCTEAK DQEPRVTEHR MGPGLSLISY TFVCRQEDFC NNLVNSLPLW
 APQPPADPGS LRCPVCLSME GCLEGTTEEI CPKGTTHCYD GLLRLRGGGI FSNLRVQGCM
 PQPGCNLLNG TQEIGPVGMT ENCNRKDFLT CHRGTTIMTH GNLAQEPTDW TTSNTEMCEV
 GQVCQETLLL LDVGLTSTLV GTKGCSTVGA QNSQKTTIHS APPGVLVASY THFCSSDLCN
 SASSSSVLLN SLPPQAAPVP GDRQCPTCVQ PLGTCSSGSP RMTCPRGATH CYDGYIHLSG
 GGLSTKMSIQ GCVAQPSSFL LNHTRQIGIF SAREKRDVQP PASQHEGGGA EGLESLTWGV
 GLALAPALWW GVVCPSC

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