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CD2 antigen (T-cell surface antigen CD2)

 Q549Q4_MOUSE            Unreviewed;       344 AA.
Q549Q4;
05-FEB-2008, integrated into UniProtKB/TrEMBL.
05-FEB-2008, sequence version 1.
25-OCT-2017, entry version 87.
SubName: Full=CD2 antigen {ECO:0000313|EMBL:EDL07629.1};
SubName: Full=T-cell surface antigen CD2 {ECO:0000313|EMBL:AAD25888.1};
Name=Cd2 {ECO:0000313|EMBL:EDL07629.1, ECO:0000313|MGI:MGI:88320};
ORFNames=mCG_7804 {ECO:0000313|EMBL:EDL07629.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:AAD25888.1};
[1] {ECO:0000313|EMBL:AAD25888.1}
NUCLEOTIDE SEQUENCE.
STRAIN=DBA/2J {ECO:0000313|EMBL:AAD25886.1},
NOD/LtJ {ECO:0000313|EMBL:AAD25887.1}, and
RIIIS/J {ECO:0000313|EMBL:AAD25888.1};
TISSUE=Spleen {ECO:0000313|EMBL:AAD25888.1};
Ma R.Z., Teuscher C.;
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:EDL07629.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL07629.1};
PubMed=12040188; DOI=10.1126/science.1069193;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and
the human genome.";
Science 296:1661-1671(2002).
[3] {ECO:0000313|EMBL:EDL07629.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL07629.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AF065906; AAD25886.1; -; mRNA.
EMBL; AF065907; AAD25887.1; -; mRNA.
EMBL; AF065908; AAD25888.1; -; mRNA.
EMBL; CH466608; EDL07629.1; -; Genomic_DNA.
RefSeq; NP_038514.1; NM_013486.2.
UniGene; Mm.22842; -.
GeneID; 12481; -.
KEGG; mmu:12481; -.
CTD; 914; -.
MGI; MGI:88320; Cd2.
eggNOG; ENOG410IW98; Eukaryota.
eggNOG; ENOG410Y7BE; LUCA.
HOVERGEN; HBG000262; -.
KO; K06449; -.
OMA; GTQVHQQ; -.
OrthoDB; EOG091G0M7A; -.
Bgee; ENSMUSG00000027863; -.
GO; GO:0046658; C:anchored component of plasma membrane; IEA:Ensembl.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0005102; F:receptor binding; IEA:Ensembl.
GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:1902715; P:positive regulation of interferon-gamma secretion; IEA:Ensembl.
GO; GO:2000484; P:positive regulation of interleukin-8 secretion; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR015632; CD2.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR008424; Ig_C2-set.
InterPro; IPR013106; Ig_V-set.
Pfam; PF05790; C2-set; 1.
Pfam; PF07686; V-set; 1.
PRINTS; PR01870; CD2ANTIGEN.
SUPFAM; SSF48726; SSF48726; 2.
2: Evidence at transcript level;
Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 344 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5011099278.
TRANSMEM 202 229 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 25 120 IGv. {ECO:0000259|Pfam:PF07686}.
DOMAIN 129 199 C2-set. {ECO:0000259|Pfam:PF05790}.
SEQUENCE 344 AA; 38415 MW; CFD12FCBD1444450 CRC64;
MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID EVRWVRRGTL
VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN VMVYGTNGMT RLEKDLDVRI
LERVSKPMIH WECPNTTLTC AVLQGTDFEL KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC
EAINPVSKES KMEVVNCPEK GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD
EELEIKASRT STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH
QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN


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