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CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)

 CD276_HUMAN             Reviewed;         534 AA.
Q5ZPR3; Q6P5Y4; Q6UXI2; Q8NBI8; Q8NC34; Q8NCB6; Q9BXR1;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
25-OCT-2017, entry version 127.
RecName: Full=CD276 antigen;
AltName: Full=4Ig-B7-H3;
AltName: Full=B7 homolog 3;
Short=B7-H3;
AltName: Full=Costimulatory molecule;
AltName: CD_antigen=CD276;
Flags: Precursor;
Name=CD276; Synonyms=B7H3; ORFNames=PSEC0249, UNQ309/PRO352;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND
FUNCTION.
PubMed=11224528; DOI=10.1038/85339;
Chapoval A.I., Ni J., Lau J.S., Wilcox R.A., Flies D.B., Liu D.,
Dong H., Sica G.L., Zhu G., Tamada K., Chen L.;
"B7-H3: a costimulatory molecule for T cell activation and IFN-gamma
production.";
Nat. Immunol. 2:269-274(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION,
AND INDUCTION.
PubMed=14764704; DOI=10.4049/jimmunol.172.4.2352;
Steinberger P., Majdic O., Derdak S.V., Pfistershammer K.,
Kirchberger S., Klauser C., Zlabinger G., Pickl W.F., Stockl J.,
Knapp W.;
"Molecular characterization of human 4Ig-B7-H3, a member of the B7
family with four Ig-like domains.";
J. Immunol. 172:2352-2359(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 91-534 (ISOFORM 1), AND VARIANT
MET-160.
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
MET-160.
PubMed=16303743; DOI=10.1093/dnares/12.2.117;
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
Isogai T.;
"Signal sequence and keyword trap in silico for selection of full-
length human cDNAs encoding secretion or membrane proteins from oligo-
capped cDNA libraries.";
DNA Res. 12:117-126(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 29-43.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally
verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[8]
FUNCTION, AND GENOMIC DOMAIN DUPLICATION.
PubMed=12906861; DOI=10.1016/S0888-7543(03)00126-5;
Ling V., Wu P.W., Spaulding V., Kieleczawa J., Luxenberg D.,
Carreno B.M., Collins M.;
"Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like
domains: divergent history of functional redundancy and exon loss.";
Genomics 82:365-377(2003).
[9]
FUNCTION.
PubMed=15314238; DOI=10.1073/pnas.0405025101;
Castriconi R., Dondero A., Augugliaro R., Cantoni C., Carnemolla B.,
Sementa A.R., Negri F., Conte R., Corrias M.V., Moretta L.,
Moretta A., Bottino C.;
"Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule
that exerts a protective role from an NK cell-mediated lysis.";
Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645(2004).
[10]
TISSUE SPECIFICITY.
PubMed=16049332; DOI=10.1016/S0002-9440(10)62990-2;
Petroff M.G., Kharatyan E., Torry D.S., Holets L.;
"The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are
differentially expressed across gestation in the human placenta.";
Am. J. Pathol. 167:465-473(2005).
[11]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=15961727; DOI=10.1165/rcmb.2004-0129OC;
Kim J., Myers A.C., Chen L., Pardoll D.M., Truong-Tran Q.A.,
Lane A.P., McDyer J.F., Fortuno L., Schleimer R.P.;
"Constitutive and inducible expression of B7 family of ligands by
human airway epithelial cells.";
Am. J. Respir. Cell Mol. Biol. 33:280-289(2005).
[12]
TISSUE SPECIFICITY.
PubMed=16274630;
Zhang G.B., Dong Q.M., Xu Y., Yu G.H., Zhang X.G.;
"B7-H3: another molecule marker for Mo-DCs?";
Cell. Mol. Immunol. 2:307-311(2005).
[13]
FUNCTION, AND INDUCTION.
PubMed=15682454; DOI=10.1002/eji.200425518;
Wang L., Fraser C.C., Kikly K., Wells A.D., Han R., Coyle A.J.,
Chen L., Hancock W.W.;
"B7-H3 promotes acute and chronic allograft rejection.";
Eur. J. Immunol. 35:428-438(2005).
[14]
INTERACTION WITH TREML2.
PubMed=18650384; DOI=10.1073/pnas.0802423105;
Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H.,
Azuma M.;
"Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-
2) is a counter-receptor for B7-H3 and enhances T cell responses.";
Proc. Natl. Acad. Sci. U.S.A. 105:10495-10500(2008).
[15]
ERRATUM.
Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H.,
Azuma M.;
Proc. Natl. Acad. Sci. U.S.A. 105:14744-14744(2008).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[17]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of
multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[18]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[19]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
-!- FUNCTION: May participate in the regulation of T-cell-mediated
immune response. May play a protective role in tumor cells by
inhibiting natural-killer mediated cell lysis as well as a role of
marker for detection of neuroblastoma cells. May be involved in
the development of acute and chronic transplant rejection and in
the regulation of lymphocytic activity at mucosal surfaces. Could
also play a key role in providing the placenta and fetus with a
suitable immunological environment throughout pregnancy. Both
isoform 1 and isoform 2 appear to be redundant in their ability to
modulate CD4 T-cell responses. Isoform 2 is shown to enhance the
induction of cytotoxic T-cells and selectively stimulates
interferon gamma production in the presence of T-cell receptor
signaling. {ECO:0000269|PubMed:11224528,
ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704,
ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454,
ECO:0000269|PubMed:15961727}.
-!- SUBUNIT: Interacts with TREML2 and this interaction enhances T-
cell activation. {ECO:0000269|PubMed:18650384}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1; Synonyms=4Ig-B7-H3;
IsoId=Q5ZPR3-1; Sequence=Displayed;
Note=Contains tandemly repeated immunoglobulin-like V and C
domains.;
Name=2; Synonyms=B7-H3;
IsoId=Q5ZPR3-2; Sequence=VSP_017088;
Note=Minor transcript. Contains one single set of
immunoglobulin-like V and C domains.;
Name=3;
IsoId=Q5ZPR3-3; Sequence=VSP_017089, VSP_017090;
Note=Contains tandemly repeated immunoglobulin-like V and C
domains.;
Name=4;
IsoId=Q5ZPR3-4; Sequence=VSP_017091;
Note=Contains tandemly repeated immunoglobulin-like V and C
domains.;
-!- TISSUE SPECIFICITY: Ubiquitous but not detectable in peripheral
blood lymphocytes or granulocytes. Weakly expressed in resting
monocytes. Expressed in dendritic cells derived from monocytes.
Expressed in epithelial cells of sinonasal tissue. Expressed in
extravillous trophoblast cells and Hofbauer cells of the first
trimester placenta and term placenta.
{ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:14764704,
ECO:0000269|PubMed:15961727, ECO:0000269|PubMed:16049332,
ECO:0000269|PubMed:16274630}.
-!- INDUCTION: By bacterial lipopolysaccharides (LPS) in monocytes and
by ionomycin in T and B-lymphocytes. Up-regulated in cells
mediating rejection of human transplants.
{ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15682454}.
-!- MISCELLANEOUS: B7-H3 locus underwent genomic duplication leading
to tandemly repeated immunoglobulin-like V and C domains (VC
domains). The dominantly expressed human B7-H3 isoform contains
tandemly duplicated VC domains. In contrast, mouse B7-H3
transcript contains only one single VC domain form due to an exon
structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-
C domain. This duplication appearing in primates is suggested to
be very recent supporting a model of multiple independent
emergence of tandem VC repeats within human and monkey species.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAC11344.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF302102; AAK15438.1; -; mRNA.
EMBL; AJ583695; CAE47548.1; -; mRNA.
EMBL; AY358343; AAQ88709.1; -; mRNA.
EMBL; AK074849; BAC11243.1; -; mRNA.
EMBL; AK074997; BAC11344.1; ALT_INIT; mRNA.
EMBL; AK075549; BAC11692.1; -; mRNA.
EMBL; BC062581; AAH62581.1; -; mRNA.
CCDS; CCDS10251.1; -. [Q5ZPR3-2]
CCDS; CCDS32288.1; -. [Q5ZPR3-1]
RefSeq; NP_001019907.1; NM_001024736.1. [Q5ZPR3-1]
RefSeq; NP_001316557.1; NM_001329628.1. [Q5ZPR3-2]
RefSeq; NP_001316558.1; NM_001329629.1.
RefSeq; NP_079516.1; NM_025240.2. [Q5ZPR3-2]
RefSeq; XP_005254757.1; XM_005254700.4.
RefSeq; XP_011520397.1; XM_011522095.2. [Q5ZPR3-1]
RefSeq; XP_011520398.1; XM_011522096.2. [Q5ZPR3-1]
RefSeq; XP_016878127.1; XM_017022638.1. [Q5ZPR3-1]
UniGene; Hs.744915; -.
ProteinModelPortal; Q5ZPR3; -.
BioGrid; 123260; 11.
IntAct; Q5ZPR3; 1.
MINT; MINT-5000152; -.
STRING; 9606.ENSP00000320084; -.
GuidetoPHARMACOLOGY; 2938; -.
iPTMnet; Q5ZPR3; -.
PhosphoSitePlus; Q5ZPR3; -.
SwissPalm; Q5ZPR3; -.
BioMuta; CD276; -.
DMDM; 74757248; -.
EPD; Q5ZPR3; -.
MaxQB; Q5ZPR3; -.
PaxDb; Q5ZPR3; -.
PeptideAtlas; Q5ZPR3; -.
PRIDE; Q5ZPR3; -.
Ensembl; ENST00000318424; ENSP00000320058; ENSG00000103855. [Q5ZPR3-2]
Ensembl; ENST00000318443; ENSP00000320084; ENSG00000103855. [Q5ZPR3-1]
Ensembl; ENST00000561213; ENSP00000452736; ENSG00000103855. [Q5ZPR3-4]
Ensembl; ENST00000564751; ENSP00000454940; ENSG00000103855. [Q5ZPR3-2]
GeneID; 80381; -.
KEGG; hsa:80381; -.
UCSC; uc002avu.2; human. [Q5ZPR3-1]
CTD; 80381; -.
DisGeNET; 80381; -.
EuPathDB; HostDB:ENSG00000103855.17; -.
GeneCards; CD276; -.
HGNC; HGNC:19137; CD276.
HPA; CAB017826; -.
HPA; HPA009285; -.
HPA; HPA017139; -.
MIM; 605715; gene.
neXtProt; NX_Q5ZPR3; -.
OpenTargets; ENSG00000103855; -.
PharmGKB; PA142672148; -.
eggNOG; ENOG410IR2H; Eukaryota.
eggNOG; ENOG410ZB69; LUCA.
GeneTree; ENSGT00700000104325; -.
HOVERGEN; HBG079786; -.
InParanoid; Q5ZPR3; -.
KO; K06746; -.
OMA; FESPSHY; -.
OrthoDB; EOG091G0IEZ; -.
PhylomeDB; Q5ZPR3; -.
TreeFam; TF331083; -.
ChiTaRS; CD276; human.
GeneWiki; CD276; -.
GenomeRNAi; 80381; -.
PRO; PR:Q5ZPR3; -.
Proteomes; UP000005640; Chromosome 15.
Bgee; ENSG00000103855; -.
CleanEx; HS_CD276; -.
ExpressionAtlas; Q5ZPR3; baseline and differential.
Genevisible; Q5ZPR3; HS.
GO; GO:0009897; C:external side of plasma membrane; NAS:HGNC.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; NAS:HGNC.
GO; GO:0005102; F:receptor binding; NAS:HGNC.
GO; GO:0008283; P:cell proliferation; NAS:UniProtKB.
GO; GO:0006955; P:immune response; NAS:UniProtKB.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IDA:HGNC.
GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:HGNC.
GO; GO:0050776; P:regulation of immune response; NAS:HGNC.
GO; GO:0042110; P:T cell activation; IDA:UniProtKB.
Gene3D; 2.60.40.10; -; 4.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 2.
SMART; SM00409; IG; 4.
SMART; SM00407; IGc1; 2.
SMART; SM00408; IGc2; 4.
SMART; SM00406; IGv; 2.
SUPFAM; SSF48726; SSF48726; 4.
PROSITE; PS50835; IG_LIKE; 4.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 28 {ECO:0000269|PubMed:15340161}.
CHAIN 29 534 CD276 antigen.
/FTId=PRO_0000045801.
TOPO_DOM 29 466 Extracellular. {ECO:0000255}.
TRANSMEM 467 487 Helical. {ECO:0000255}.
TOPO_DOM 488 534 Cytoplasmic. {ECO:0000255}.
DOMAIN 29 139 Ig-like V-type 1.
DOMAIN 145 238 Ig-like C2-type 1.
DOMAIN 243 357 Ig-like V-type 2.
DOMAIN 363 456 Ig-like C2-type 2.
MOD_RES 525 525 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:24275569}.
CARBOHYD 104 104 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 189 189 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 215 215 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 322 322 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19159218}.
CARBOHYD 407 407 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19159218}.
CARBOHYD 433 433 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 50 122 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 165 220 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 268 340 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 383 438 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VAR_SEQ 159 376 Missing (in isoform 2).
{ECO:0000303|PubMed:11224528,
ECO:0000303|PubMed:12975309}.
/FTId=VSP_017088.
VAR_SEQ 465 493 EALWVTVGLSVCLIALLVALAFVCWRKIK -> GPASSAVP
LSPAHPPHGSMCWSHWFSRGL (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_017089.
VAR_SEQ 494 534 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_017090.
VAR_SEQ 528 534 DDGQEIA -> GKDTWA (in isoform 4).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_017091.
VARIANT 97 97 P -> L (in dbSNP:rs7173448).
/FTId=VAR_049857.
VARIANT 111 111 R -> S (in dbSNP:rs7173476).
/FTId=VAR_049858.
VARIANT 137 137 Q -> L (in dbSNP:rs11574477).
/FTId=VAR_049859.
VARIANT 160 160 T -> M (in dbSNP:rs11574479).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:16303743}.
/FTId=VAR_049860.
VARIANT 267 267 R -> H (in dbSNP:rs11574483).
/FTId=VAR_049861.
VARIANT 279 279 A -> T (in dbSNP:rs10083681).
/FTId=VAR_049862.
VARIANT 315 315 P -> L (in dbSNP:rs7173448).
/FTId=VAR_049863.
VARIANT 329 329 R -> S (in dbSNP:rs7173476).
/FTId=VAR_049864.
VARIANT 378 378 T -> M (in dbSNP:rs11574479).
/FTId=VAR_049865.
CONFLICT 387 387 R -> Q (in Ref. 3; AAQ88709).
{ECO:0000305}.
CONFLICT 473 473 L -> P (in Ref. 4; BAC11243).
{ECO:0000305}.
SEQUENCE 534 AA; 57235 MW; 2181A064404C7939 CRC64;
MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL
AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF
TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD
GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ
RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG
RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY
SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF
DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPEALWVT VGLSVCLIAL
LVALAFVCWR KIKQSCEEEN AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA


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