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CD44 antigen

 A2APM2_MOUSE            Unreviewed;       780 AA.
A2APM2;
20-FEB-2007, integrated into UniProtKB/TrEMBL.
20-FEB-2007, sequence version 1.
30-AUG-2017, entry version 95.
SubName: Full=CD44 antigen {ECO:0000313|Ensembl:ENSMUSP00000005218};
Name=Cd44 {ECO:0000313|Ensembl:ENSMUSP00000005218,
ECO:0000313|MGI:MGI:88338};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000005218, ECO:0000313|Proteomes:UP000000589};
[1] {ECO:0000213|PubMed:19144319}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[2] {ECO:0000313|Ensembl:ENSMUSP00000005218, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000005218,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4] {ECO:0000313|Ensembl:ENSMUSP00000005218}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000005218};
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000005218}.
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EMBL; AL844155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_033981.2; NM_009851.2.
UniGene; Mm.423621; -.
ProteinModelPortal; A2APM2; -.
SMR; A2APM2; -.
MaxQB; A2APM2; -.
PaxDb; A2APM2; -.
PRIDE; A2APM2; -.
Ensembl; ENSMUST00000005218; ENSMUSP00000005218; ENSMUSG00000005087.
GeneID; 12505; -.
KEGG; mmu:12505; -.
UCSC; uc008lie.2; mouse.
CTD; 960; -.
MGI; MGI:88338; Cd44.
eggNOG; ENOG410IZCP; Eukaryota.
eggNOG; ENOG4111S6T; LUCA.
GeneTree; ENSGT00530000063822; -.
HOGENOM; HOG000231746; -.
HOVERGEN; HBG003850; -.
KO; K06256; -.
OMA; SHPMGRG; -.
OrthoDB; EOG091G0F98; -.
PhylomeDB; A2APM2; -.
TreeFam; TF334173; -.
Reactome; R-MMU-1474228; Degradation of the extracellular matrix.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
Reactome; R-MMU-216083; Integrin cell surface interactions.
Reactome; R-MMU-2160916; Hyaluronan uptake and degradation.
Reactome; R-MMU-6798695; Neutrophil degranulation.
ChiTaRS; Cd44; mouse.
PMAP-CutDB; A2APM2; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000005087; -.
ExpressionAtlas; A2APM2; baseline and differential.
Genevisible; A2APM2; MM.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031258; C:lamellipodium membrane; IEA:Ensembl.
GO; GO:0035692; C:macrophage migration inhibitory factor receptor complex; IEA:Ensembl.
GO; GO:0004896; F:cytokine receptor activity; IEA:Ensembl.
GO; GO:0005540; F:hyaluronic acid binding; IEA:Ensembl.
GO; GO:0051216; P:cartilage development; IEA:Ensembl.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
GO; GO:0070487; P:monocyte aggregation; IEA:Ensembl.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:1900625; P:positive regulation of monocyte aggregation; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:2000392; P:regulation of lamellipodium morphogenesis; IEA:Ensembl.
GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR016186; C-type_lectin-like/link.
InterPro; IPR001231; CD44_antigen.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR000538; Link_dom.
PANTHER; PTHR10225:SF8; PTHR10225:SF8; 1.
Pfam; PF00193; Xlink; 1.
PRINTS; PR00658; CD44.
PRINTS; PR01265; LINKMODULE.
SMART; SM00445; LINK; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS01241; LINK_1; 1.
PROSITE; PS50963; LINK_2; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000000589};
Membrane {ECO:0000256|SAM:Phobius};
Proteomics identification {ECO:0000213|EPD:A2APM2,
ECO:0000213|MaxQB:A2APM2, ECO:0000213|PeptideAtlas:A2APM2};
Reference proteome {ECO:0000313|Proteomes:UP000000589};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 780 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5002642731.
TRANSMEM 688 709 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 36 125 Link. {ECO:0000259|PROSITE:PS50963}.
SEQUENCE 780 AA; 85838 MW; 96A067F59E18CBEE CRC64;
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR TEAADLCQAF
NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI CAANHTGVYI LVTSNTSHYD
TYCFNASAPP EEDCTSVTDL PNSFDGPVTI TIVNRDGTRY SKKGEYRTHQ EDIDASNIID
DDVSSGSTIE KSTPESYILH TYLPTEQPTG DQDDSFFIRS TLATIASTVH SKSHAAAQKQ
NNWIWSWFGN SQSTTQTQEP TTSATTALMT TPETPPKRQE AQNWFSWLFQ PSESKSHLHT
TTKMPGTESN TNPTGWEPNE ENEDETDKYP SFSGSGIDDD EDFISSTIAS TPRVSARTED
NQDWTQWKPN HSNPEVLLQT TTRMADIDRI STSAHGENWT PEPQPPFNNH EYQDEEETPH
ATSTTPNSTA EAAATQQETW FQNGWQGKNP PTPSEDSHVT EGTTASAHNN HPSQRITTQS
QEDVSWTDFF DPISHPMGQG HQTESKDTDS SHSTTLQPTA APNTHLVEDL NRTGPLSVTT
PQSHSQNFST LHGEPEEDEN HPTTSILPSS TKSGAKDARR GGSLPTDTTT SVEGYTFQYP
DTMENGTLFP VTPAKTEVFG ETEVTLATDS NVNVDGSLPG DRDSSKDSRG SSRTVTHGSE
LAGHSSANQD SGVTTTSGPM RRPQIPEWLI ILASLLALAL ILAVCIAVNS RRRCGQKKKL
VINGGNGTVE DRKPSELNGE ASKSQEMVHL VNKEPSETPD QCMTADETRN LQSVDMKIGV


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PB-221-T025 Mouse Monoclonal to CD44 _ Pgp_1 Antigen CD44 Isotype IgG2b Antigen CD44 Isotype IgG2b 25 tests
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1A-341-T025 Mouse Monoclonal to CD44 _ Pgp_1 Antigen CD44 Isotype IgG1 Antigen CD44 Isotype IgG1 25 tests
1P-221-T100 Mouse Monoclonal to CD44 _ Pgp_1 Antigen CD44 Isotype IgG2b Antigen CD44 Isotype IgG2b 100 tests
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A4-221-T025 Mouse Monoclonal to CD44 _ Pgp_1 Antigen CD44 Isotype IgG2b Antigen CD44 Isotype IgG2b 25 tests
1P-341-T100 Mouse Monoclonal to CD44 _ Pgp_1 Antigen CD44 Isotype IgG1 Antigen CD44 Isotype IgG1 100 tests
1P-341-T025 Mouse Monoclonal to CD44 _ Pgp_1 Antigen CD44 Isotype IgG1 Antigen CD44 Isotype IgG1 25 tests
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