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CD45

 Q6ED62_AOTNI            Unreviewed;      1303 AA.
Q6ED62;
16-AUG-2004, integrated into UniProtKB/TrEMBL.
16-AUG-2004, sequence version 1.
23-MAY-2018, entry version 88.
SubName: Full=CD45 {ECO:0000313|EMBL:AAS06901.1};
Aotus nigriceps (Black-headed night monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Aotidae; Aotus.
NCBI_TaxID=57175 {ECO:0000313|EMBL:AAS06901.1};
[1] {ECO:0000313|EMBL:AAS06901.1}
NUCLEOTIDE SEQUENCE.
PubMed=15245371; DOI=10.1111/j.0001-2815.2004.00279.x;
Montoya G.E., Vernot J.P., Patarroyo M.E.;
"Comparative analysis of CD45 proteins in primate context: owl monkeys
vs humans.";
Tissue Antigens 64:165-172(2004).
-!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
tyrosine + phosphate. {ECO:0000256|SAAS:SAAS00697399}.
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EMBL; AY445816; AAS06901.1; -; mRNA.
ProteinModelPortal; Q6ED62; -.
HOVERGEN; HBG000066; -.
GO; GO:0005925; C:focal adhesion; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
GO; GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
GO; GO:0042100; P:B cell proliferation; ISS:UniProtKB.
GO; GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.
GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
GO; GO:0016311; P:dephosphorylation; ISS:UniProtKB.
GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.
GO; GO:0001915; P:negative regulation of T cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0050857; P:positive regulation of antigen receptor-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.
GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.40.10; -; 2.
Gene3D; 3.90.190.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
InterPro; IPR024739; PTP_recept_N.
InterPro; IPR000242; PTPase_domain.
InterPro; IPR016335; Ptprc.
InterPro; IPR016130; Tyr_Pase_AS.
InterPro; IPR003595; Tyr_Pase_cat.
InterPro; IPR000387; TYR_PHOSPHATASE_dom.
Pfam; PF12567; CD45; 1.
Pfam; PF00041; fn3; 1.
Pfam; PF12453; PTP_N; 1.
Pfam; PF00102; Y_phosphatase; 2.
PIRSF; PIRSF002004; Leukocyte_common_antigen; 1.
PRINTS; PR00700; PRTYPHPHTASE.
SMART; SM00060; FN3; 2.
SMART; SM00194; PTPc; 2.
SMART; SM00404; PTPc_motif; 2.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF52799; SSF52799; 2.
PROSITE; PS50853; FN3; 2.
PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Hydrolase {ECO:0000256|SAAS:SAAS01031415};
Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00897767,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 25 {ECO:0000256|SAM:SignalP}.
CHAIN 26 1303 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004272779.
TRANSMEM 575 596 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 392 480 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 484 573 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 650 909 Tyrosine-protein phosphatase.
{ECO:0000259|PROSITE:PS50055}.
DOMAIN 829 900 TYR_PHOSPHATASE_2.
{ECO:0000259|PROSITE:PS50056}.
DOMAIN 941 1225 Tyrosine-protein phosphatase.
{ECO:0000259|PROSITE:PS50055}.
DOMAIN 1132 1216 TYR_PHOSPHATASE_2.
{ECO:0000259|PROSITE:PS50056}.
COILED 1235 1255 {ECO:0000256|SAM:Coils}.
ACT_SITE 850 850 Phosphocysteine intermediate.
{ECO:0000256|PIRSR:PIRSR002004-1,
ECO:0000256|PROSITE-ProRule:PRU00160}.
ACT_SITE 1166 1166 Phosphocysteine intermediate.
{ECO:0000256|PIRSR:PIRSR002004-1,
ECO:0000256|PROSITE-ProRule:PRU00160}.
SEQUENCE 1303 AA; 146587 MW; 9BB023EBF4BC1165 CRC64;
MTMYLWLKLL AFGFAFLDTE VFVAGENPTS PTTGPTATKK SSVPLSGDPL PTHTTAFSPA
SISERENGFL ETTPSLSPAS TSTQVSLDSL DNASAFKTTG VPSEQPPHLP THADSQTPSA
GTDTQALSGL AAHATLSPAP GSNDASDVPG ERSTASTFPT DPVFPLGTTP IPARNSSAAL
PARTANTTIT ASSPDSHASE TITLSPSGSS AHSTKIVATT PTKPSCDEKY ANITVDYSYD
NNTKLFTAKL NVNEVVKCAD FDCTNNMLHN LKECEIRAVT ISDNSCTAPN NTLKLDVPPG
VEKFHLKDHT SPEKANTTII LKWETSENFT CDRNKITYRF QCGKITSDKE YIVLEDRKPN
HNYTCDSEIL YNHRKYININ ETIQTDFGIP EEPQNVTCRS EGAHEGVITW NHPHSLFHSF
TLCFQNKPDN CFQVDKNLTK CDLQNLKPYT KYISSLYAYI IARAQRNGTA VPCHFTTNSA
RPSEVQNMTV SITSENSMLV KCNAPKDLNG PRGRYHLEVK DGDSLVRNES NHPCLFSVKD
LQYSTNYTFQ AYYHNGDYPG DPVSQFQSTS YNFKALIAFL AFLIIVTSIA LLVVLYKIYD
LHKKRSCNLD EQQELVERDD EKQLMNVEPI HADILLKLYK RKIADEGRLF LAEFQSIPRV
FSKFPIKEAR KSFIQNKNRY VDILPYDYNR EELSEINGDA GSNYINASYI DGFKEPRKYI
AAQGPRDETV DDFWRMIWEQ KATVIVMVTR CEEGNRNKCA SYWPSVEEGT RAFGDVVVKI
NQHKRCPDYI IQKLNIVNKK EKTAGREVTH IQFTSWPDHG VPEDPHLLLK LRRRVNAFSN
FFSGPIVVHC SAGVGRTGTY IGIDAMLEGL EAENKVDVYG YVVKLRRQRC LMVQVEAQYI
LIHQALVEYN QFGETEVNLS ELHPYLHNMK KRDPPSEPSP LEAEFQRLPS YRSWRTQHIG
NQEENKVKNR NSNVIPYDFN RVPLKHELEM SKESEHDSDE SSDDDSDSEE ASKYINASFI
MSYWKPEVMI AAQGPLKETI GDFWQMIFQR KVKAIVMLTE LKRGDQELCA QYWGEGKQTY
GDIEVDLKDT NKSSTYTLHV FELRHSKRKD PRTVYQYQYT NWSAEQLPAE PKELISMIQV
LKQKLPQKNS SEGNKYHKSA PLLIHCRDGS QQTGIFCALL NLLESAETEE VVDVFQVVKA
LRKARPGMIS TFEQYQFLYD TIASTYPAQN GQVKKNNHQE DKIEFDNEVD KVKQDANCVN
PLGAPEKLPE ANEQAASSEP TSGTEGPEHC VNGPASPALN QGS


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