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CD48 antigen (BCM1 surface antigen) (BLAST-1) (MRC OX-45 surface antigen) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (CD antigen CD48)

 CD48_RAT                Reviewed;         240 AA.
P10252;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
05-DEC-2018, entry version 154.
RecName: Full=CD48 antigen;
AltName: Full=BCM1 surface antigen;
AltName: Full=BLAST-1;
AltName: Full=MRC OX-45 surface antigen {ECO:0000303|PubMed:3181129};
AltName: Full=SLAM family member 2;
Short=SLAMF2;
AltName: Full=Signaling lymphocytic activation molecule 2;
AltName: CD_antigen=CD48;
Flags: Precursor;
Name=Cd48; Synonyms=Bcm-1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT
ASN-186 AND ASN-203, SUBCELLULAR LOCATION, GPI-ANCHOR AT SER-217, AND
DISULFIDE BOND.
PubMed=3181129;
Killeen N., Moessner R., Arvieux J., Willis A., Williams A.F.;
"The MRC OX-45 antigen of rat leukocytes and endothelium is in a
subset of the immunoglobulin superfamily with CD2, LFA-3 and
carcinoembryonic antigens.";
EMBO J. 7:3087-3091(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 23-125 IN COMPLEX WITH CD2,
INTERACTION WITH CD2 AND CD244, AND GLYCOSYLATION AT ASN-38 AND
ASN-97.
PubMed=16803907; DOI=10.1074/jbc.M601314200;
Evans E.J., Castro M.A., O'Brien R., Kearney A., Walsh H.,
Sparks L.M., Tucknott M.G., Davies E.A., Carmo A.M.,
van der Merwe P.A., Stuart D.I., Jones E.Y., Ladbury J.E., Ikemizu S.,
Davis S.J.;
"Crystal structure and binding properties of the CD2 and CD244 (2B4)-
binding protein, CD48.";
J. Biol. Chem. 281:29309-29320(2006).
-!- FUNCTION: Ligand for CD2. Might facilitate interaction between
activated lymphocytes. Probably involved in regulating T-cell
activation.
-!- SUBUNIT: Interacts with CD2. Interacts with CD244 in a
heterophilic manner. {ECO:0000269|PubMed:16803907}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3181129};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:3181129}.
-----------------------------------------------------------------------
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EMBL; X13016; CAA31438.1; -; mRNA.
EMBL; BC060542; AAH60542.1; -; mRNA.
PIR; S01299; S01299.
RefSeq; NP_620803.1; NM_139103.1.
UniGene; Rn.3705; -.
PDB; 2DRU; X-ray; 2.60 A; A=23-125.
PDBsum; 2DRU; -.
ProteinModelPortal; P10252; -.
SMR; P10252; -.
STRING; 10116.ENSRNOP00000006306; -.
GlyConnect; 371; -.
iPTMnet; P10252; -.
PhosphoSitePlus; P10252; -.
UniCarbKB; P10252; -.
PaxDb; P10252; -.
PRIDE; P10252; -.
Ensembl; ENSRNOT00000006306; ENSRNOP00000006306; ENSRNOG00000004737.
GeneID; 245962; -.
KEGG; rno:245962; -.
UCSC; RGD:620620; rat.
CTD; 962; -.
RGD; 620620; Cd48.
eggNOG; ENOG410J3RS; Eukaryota.
eggNOG; ENOG410ZR3T; LUCA.
GeneTree; ENSGT00940000153122; -.
HOGENOM; HOG000111487; -.
HOVERGEN; HBG004490; -.
InParanoid; P10252; -.
KO; K06479; -.
OMA; SSGVAWI; -.
OrthoDB; EOG091G0K94; -.
PhylomeDB; P10252; -.
TreeFam; TF334964; -.
Reactome; R-RNO-202733; Cell surface interactions at the vascular wall.
EvolutionaryTrace; P10252; -.
PRO; PR:P10252; -.
Proteomes; UP000002494; Chromosome 13.
Bgee; ENSRNOG00000004737; Expressed in 9 organ(s), highest expression level in lung.
Genevisible; P10252; RN.
GO; GO:0046658; C:anchored component of plasma membrane; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0003823; F:antigen binding; IMP:RGD.
GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
GO; GO:0045576; P:mast cell activation; IMP:RGD.
GO; GO:0002819; P:regulation of adaptive immune response; IEA:InterPro.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR033548; CD48.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
PANTHER; PTHR12080:SF47; PTHR12080:SF47; 1.
Pfam; PF13895; Ig_2; 1.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor;
Immunoglobulin domain; Lipoprotein; Membrane; Reference proteome;
Repeat; Signal.
SIGNAL 1 22
CHAIN 23 217 CD48 antigen.
/FTId=PRO_0000014885.
PROPEP 218 240 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000014886.
DOMAIN 29 127 Ig-like C2-type 1.
DOMAIN 131 207 Ig-like C2-type 2.
LIPID 217 217 GPI-anchor amidated serine.
{ECO:0000269|PubMed:3181129}.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:16803907}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:16803907}.
CARBOHYD 140 140 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 186 186 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:3181129}.
CARBOHYD 203 203 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:3181129}.
DISULFID 151 193 {ECO:0000269|PubMed:3181129}.
STRAND 30 34 {ECO:0000244|PDB:2DRU}.
STRAND 39 41 {ECO:0000244|PDB:2DRU}.
STRAND 52 61 {ECO:0000244|PDB:2DRU}.
STRAND 63 67 {ECO:0000244|PDB:2DRU}.
STRAND 69 71 {ECO:0000244|PDB:2DRU}.
STRAND 73 75 {ECO:0000244|PDB:2DRU}.
TURN 79 83 {ECO:0000244|PDB:2DRU}.
STRAND 84 86 {ECO:0000244|PDB:2DRU}.
TURN 88 90 {ECO:0000244|PDB:2DRU}.
STRAND 93 95 {ECO:0000244|PDB:2DRU}.
HELIX 100 102 {ECO:0000244|PDB:2DRU}.
STRAND 104 125 {ECO:0000244|PDB:2DRU}.
SEQUENCE 240 AA; 27680 MW; 42CBBF9947A0E437 CRC64;
MYFKKRRWFL ILESLLLSLV TGFQDQSVPN VNAITGSNVT LTILKHPLAS YQRLTWLHTT
NQKILEYFPN GKKTVFESVF KDRVDLDKTN GALRIYNVSK EDRGDYYMRM LHETEDQWKI
TMEVYDLVSK PAIKIEKTKN LTDSCHLRLS CKVEDQGVDY TWYEDSGPFP QRNPGYVLEI
TITPHNKSTF YTCQVSNPVS SENDTLYFIP PCTLARSSGV HWIAAWLVVT LSIIPSILLA


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