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CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha)

 CD5L_HUMAN              Reviewed;         347 AA.
O43866; A8K7M5; Q6UX63;
16-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-JUN-2017, entry version 137.
RecName: Full=CD5 antigen-like;
AltName: Full=Apoptosis inhibitor expressed by macrophages {ECO:0000303|PubMed:23236605};
Short=hAIM {ECO:0000303|PubMed:23236605};
AltName: Full=CT-2 {ECO:0000303|Ref.2};
AltName: Full=IgM-associated peptide {ECO:0000303|PubMed:8034987};
AltName: Full=SP-alpha {ECO:0000303|PubMed:9045627};
Flags: Precursor;
Name=CD5L; Synonyms=API6;
ORFNames=UNQ203/PRO229 {ECO:0000303|PubMed:12975309};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, AND TISSUE
SPECIFICITY.
TISSUE=Spleen;
PubMed=9045627; DOI=10.1074/jbc.272.10.6151;
Gebe J.A., Kiener P.A., Ring H.Z., Li X., Francke U., Aruffo A.;
"Molecular cloning, mapping to human chromosome 1 q21-q23, and cell
binding characteristics of Spalpha, a new member of the scavenger
receptor cysteine-rich (SRCR) family of proteins.";
J. Biol. Chem. 272:6151-6158(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Miyazaki T., Yusa S.;
"Human CT-2 cDNA.";
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Spleen;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas, and Spleen;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PROTEIN SEQUENCE OF 20-31, AND INTERACTION WITH IGM.
PubMed=8034987; DOI=10.1016/0022-1759(94)90284-4;
Tissot J.-D., Schifferli J.A., Hochstrasser D.F., Pasquali C.,
Spertini F., Clement F., Frutiger S., Paquet N., Hughes G.J.,
Schneider P.;
"Two-dimensional polyacrylamide gel electrophoresis analysis of
cryoglobulins and identification of an IgM-associated peptide.";
J. Immunol. Methods 173:63-75(1994).
[9]
PARTIAL PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=11981870;
DOI=10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1;
Tissot J.D., Sanchez J.-C., Vuadens F., Scherl A., Schifferli J.A.,
Hochstrasser D.F., Schneider P., Duchosal M.A.;
"IgM are associated to Spalpha (CD5 antigen-like).";
Electrophoresis 23:1203-1206(2002).
[10]
PROTEIN SEQUENCE OF 20-34.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally
verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[11]
FUNCTION.
PubMed=16030018; DOI=10.1074/jbc.M505042200;
Sarrias M.R., Rosello S., Sanchez-Barbero F., Sierra J.M., Vila J.,
Yelamos J., Vives J., Casals C., Lozano F.;
"A role for human Sp alpha as a pattern recognition receptor.";
J. Biol. Chem. 280:35391-35398(2005).
[12]
MUTAGENESIS OF SER-123 AND 129-SER--SER-132.
PubMed=23236605; DOI=10.1016/j.febslet.2012.08.017;
Mori M., Kimura H., Iwamura Y., Arai S., Miyazaki T.;
"Modification of N-glycosylation modulates the secretion and lipolytic
function of apoptosis inhibitor of macrophage (AIM).";
FEBS Lett. 586:3569-3574(2012).
[13]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=24223991; DOI=10.1371/journal.pone.0079670;
Sanjurjo L., Amezaga N., Vilaplana C., Caceres N., Marzo E.,
Valeri M., Cardona P.J., Sarrias M.R.;
"The scavenger protein apoptosis inhibitor of macrophages (AIM)
potentiates the antimicrobial response against Mycobacterium
tuberculosis by enhancing autophagy.";
PLoS ONE 8:E79670-E79670(2013).
[14]
FUNCTION.
PubMed=24583716; DOI=10.1038/cmi.2014.12;
Martinez V.G., Escoda-Ferran C., Tadeu Simoes I., Arai S.,
Orta Mascaro M., Carreras E., Martinez-Florensa M., Yelamos J.,
Miyazaki T., Lozano F.;
"The macrophage soluble receptor AIM/Api6/CD5L displays a broad
pathogen recognition spectrum and is involved in early response to
microbial aggression.";
Cell. Mol. Immunol. 11:343-354(2014).
[15]
FUNCTION.
PubMed=24295828; DOI=10.1189/jlb.1212660;
Amezaga N., Sanjurjo L., Julve J., Aran G., Perez-Cabezas B.,
Bastos-Amador P., Armengol C., Vilella R., Escola-Gil J.C.,
Blanco-Vaca F., Borras F.E., Valledor A.F., Sarrias M.R.;
"Human scavenger protein AIM increases foam cell formation and CD36-
mediated oxLDL uptake.";
J. Leukoc. Biol. 95:509-520(2014).
[16]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[17]
SUBCELLULAR LOCATION, AND INTERACTION WITH IGM.
PubMed=24804991; DOI=10.1371/journal.pone.0097037;
Kai T., Yamazaki T., Arai S., Miyazaki T.;
"Stabilization and augmentation of circulating AIM in mice by
synthesized IgM-Fc.";
PLoS ONE 9:E97037-E97037(2014).
[18]
FUNCTION.
PubMed=25713983; DOI=10.1080/15548627.2015.1017183;
Sanjurjo L., Amezaga N., Aran G., Naranjo-Gomez M., Arias L.,
Armengol C., Borras F.E., Sarrias M.R.;
"The human CD5L/AIM-CD36 axis: A novel autophagy inducer in
macrophages that modulates inflammatory responses.";
Autophagy 11:487-502(2015).
-!- FUNCTION: Secreted protein that acts as a key regulator of lipid
synthesis: mainly expressed by macrophages in lymphoid and
inflammed tissues and regulates mechanisms in inflammatory
responses, such as infection or atherosclerosis. Able to inhibit
lipid droplet size in adipocytes. Following incorporation into
mature adipocytes via CD36-mediated endocytosis, associates with
cytosolic FASN, inhibiting fatty acid synthase activity and
leading to lipolysis, the degradation of triacylglycerols into
glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs
with progression of obesity: participates in obesity-associated
inflammation following recruitment of inflammatory macrophages
into adipose tissues, a cause of insulin resistance and obesity-
related metabolic disease. Regulation of intracellular lipids
mediated by CD5L has a direct effect on transcription regulation
mediated by nuclear receptors ROR-gamma (RORC). Acts as a key
regulator of metabolic switch in T-helper Th17 cells. Regulates
the expression of pro-inflammatory genes in Th17 cells by altering
the lipid content and limiting synthesis of cholesterol ligand of
RORC, the master transcription factor of Th17-cell
differentiation. CD5L is mainly present in non-pathogenic Th17
cells, where it decreases the content of polyunsaturated fatty
acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1,
which synthesize ligands of RORC, limiting RORC activity and
expression of pro-inflammatory genes. Participates in obesity-
associated autoimmunity via its association with IgM, interfering
with the binding of IgM to Fcalpha/mu receptor and enhancing the
development of long-lived plasma cells that produce high-affinity
IgG autoantibodies (By similarity). Also acts as an inhibitor of
apoptosis in macrophages: promotes macrophage survival from the
apoptotic effects of oxidized lipids in case of atherosclerosis
(PubMed:24295828). Involved in early response to microbial
infection against various pathogens by acting as a pattern
recognition receptor and by promoting autophagy (PubMed:16030018,
PubMed:24223991, PubMed:24583716, PubMed:25713983).
{ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:16030018,
ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24295828,
ECO:0000269|PubMed:24583716, ECO:0000269|PubMed:25713983}.
-!- SUBUNIT: Interacts with FASN; the interaction is direct (By
similarity). Interacts with IgM; protecting CD5L from renal
excretion and leading to increased CD5L levels in circulating
blood (PubMed:8034987, PubMed:24804991).
{ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:24804991,
ECO:0000269|PubMed:8034987}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24223991,
ECO:0000269|PubMed:24804991}. Cytoplasm
{ECO:0000250|UniProtKB:Q9QWK4}. Note=Secreted by macrophages and
circulates in the blood (PubMed:24223991, PubMed:24804991).
Transported in the cytoplasm via CD36-mediated endocytosis (By
similarity). {ECO:0000250|UniProtKB:Q9QWK4,
ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991}.
-!- TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, bone
marrow, and fetal liver, but not in non-lymphoid tissues.
{ECO:0000269|PubMed:9045627}.
-!- PTM: Not N-glycosylated (PubMed:23236605). Probably not O-
glycosylated (PubMed:23236605). {ECO:0000269|PubMed:23236605}.
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EMBL; U82812; AAB91989.1; -; mRNA.
EMBL; AF011429; AAD01446.1; -; mRNA.
EMBL; AY358494; AAQ88858.1; -; mRNA.
EMBL; AK292040; BAF84729.1; -; mRNA.
EMBL; AL139409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471121; EAW52859.1; -; Genomic_DNA.
EMBL; BC033586; AAH33586.1; -; mRNA.
CCDS; CCDS1171.1; -.
RefSeq; NP_001334627.1; NM_001347698.1.
RefSeq; NP_005885.1; NM_005894.2.
UniGene; Hs.134035; -.
ProteinModelPortal; O43866; -.
SMR; O43866; -.
IntAct; O43866; 7.
MINT; MINT-6769012; -.
STRING; 9606.ENSP00000357156; -.
iPTMnet; O43866; -.
PhosphoSitePlus; O43866; -.
BioMuta; CD5L; -.
PaxDb; O43866; -.
PeptideAtlas; O43866; -.
PRIDE; O43866; -.
DNASU; 922; -.
Ensembl; ENST00000368174; ENSP00000357156; ENSG00000073754.
GeneID; 922; -.
KEGG; hsa:922; -.
UCSC; uc001frk.5; human.
CTD; 922; -.
DisGeNET; 922; -.
GeneCards; CD5L; -.
HGNC; HGNC:1690; CD5L.
HPA; HPA065686; -.
HPA; HPA068384; -.
MIM; 602592; gene.
neXtProt; NX_O43866; -.
OpenTargets; ENSG00000073754; -.
PharmGKB; PA26229; -.
eggNOG; ENOG410IKHN; Eukaryota.
eggNOG; ENOG4110209; LUCA.
GeneTree; ENSGT00870000136382; -.
HOGENOM; HOG000290652; -.
HOVERGEN; HBG031373; -.
InParanoid; O43866; -.
OMA; YHGEDAS; -.
OrthoDB; EOG091G0DF7; -.
PhylomeDB; O43866; -.
TreeFam; TF329295; -.
GeneWiki; CD5L; -.
GenomeRNAi; 922; -.
PRO; PR:O43866; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000073754; -.
CleanEx; HS_CD5L; -.
Genevisible; O43866; HS.
GO; GO:0072562; C:blood microparticle; IDA:UniProtKB.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
GO; GO:0005615; C:extracellular space; TAS:ProtInc.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
Gene3D; 3.10.250.10; -; 1.
InterPro; IPR001190; SRCR.
InterPro; IPR017448; SRCR-like_dom.
Pfam; PF00530; SRCR; 3.
PRINTS; PR00258; SPERACTRCPTR.
SMART; SM00202; SR; 3.
SUPFAM; SSF56487; SSF56487; 3.
PROSITE; PS00420; SRCR_1; 2.
PROSITE; PS50287; SRCR_2; 3.
1: Evidence at protein level;
Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing;
Disulfide bond; Glycoprotein; Immunity; Inflammatory response;
Polymorphism; Reference proteome; Repeat; Secreted; Signal.
SIGNAL 1 19 {ECO:0000269|PubMed:15340161,
ECO:0000269|PubMed:8034987,
ECO:0000269|PubMed:9045627}.
CHAIN 20 347 CD5 antigen-like.
/FTId=PRO_0000033225.
DOMAIN 24 125 SRCR 1. {ECO:0000255|PROSITE-
ProRule:PRU00196}.
DOMAIN 138 239 SRCR 2. {ECO:0000255|PROSITE-
ProRule:PRU00196}.
DOMAIN 244 346 SRCR 3. {ECO:0000255|PROSITE-
ProRule:PRU00196}.
DISULFID 33 67 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 49 114 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 62 124 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 96 106 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 163 228 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 176 238 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 208 218 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 253 287 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 269 335 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 282 345 {ECO:0000255|PROSITE-ProRule:PRU00196}.
DISULFID 315 325 {ECO:0000255|PROSITE-ProRule:PRU00196}.
VARIANT 117 117 D -> E (in dbSNP:rs11537583).
/FTId=VAR_033728.
MUTAGEN 123 123 S->A: No effect; when associated with
129-A--A-132.
{ECO:0000269|PubMed:23236605}.
MUTAGEN 129 132 SSFS->AAFA: No effect; when associated
with A-123.
{ECO:0000269|PubMed:23236605}.
CONFLICT 347 347 G -> V (in Ref. 3; AAQ88858).
{ECO:0000305}.
SEQUENCE 347 AA; 38088 MW; 40A8BE08F9495D83 CRC64;
MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV
LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA
GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG
CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED
PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC
YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG


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X1782P Human, Mouse Apoptosis inhibitor of macrophages (CT) Polyclonal Antibody 100
X1782P Apoptosis inhibitor of macrophages (CT) type: Polyclonal Antibody host: Rabbit Isotype: IgG 100
X1781P Apoptosis inhibitor of macrophages type: Polyclonal Antibody host: Rabbit Isotype: IgG 100
32-128 CD14 antigen is a GPI-linked glycoprotein with a molecular weight of 55kD. The CD14 antigen is expressed on cells of the myelomonocytic lineage including monocytes, macrophages and Langerhans cells. L 0.1 mL
P-cIAP2 Inhibitor of Apoptosis Protein 2 (cIAP2) antibody, Antigen blocking peptide 100ul
U2045h CLIA API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T
U2045m CLIA Api4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,Birc5,Iap4,Mouse,Mus musculus,TIAP 96T
E2045h ELISA kit API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T
E2045h ELISA API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculoviral IAP repeat-containing protein 5,BIRC5,Homo sapiens,Human,IAP4 96T


 

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