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CD59 glycoprotein (MAC-inhibitory protein) (MAC-IP) (Membrane attack complex inhibition factor) (MACIF) (Protectin) (CD antigen CD59)

 CD59_PIG                Reviewed;         123 AA.
O62680; Q9TR76; Q9XT94;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
31-JAN-2018, entry version 111.
RecName: Full=CD59 glycoprotein;
AltName: Full=MAC-inhibitory protein;
Short=MAC-IP;
AltName: Full=Membrane attack complex inhibition factor;
Short=MACIF;
AltName: Full=Protectin;
AltName: CD_antigen=CD59;
Flags: Precursor;
Name=CD59;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Aortic endothelium;
PubMed=9558099;
Hinchliffe S.J., Rushmere N.K., Hanna S.M., Morgan B.P.;
"Molecular cloning and functional characterization of the pig analogue
of CD59: relevance to xenotransplantation.";
J. Immunol. 160:3924-3932(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 26-123, AND FUNCTION.
TISSUE=Aortic endothelium;
PubMed=9808497; DOI=10.1097/00007890-199810270-00021;
Maher S.E., Pflugh D.L., Larsen N.J., Rothschild M.F.,
Bothwell A.L.M.;
"Structure/function characterization of porcine CD59: expression,
chromosomal mapping, complement-inhibition, and costimulatory
activity.";
Transplantation 66:1094-1100(1998).
[3]
PROTEIN SEQUENCE OF 26-64.
TISSUE=Erythrocyte;
PubMed=7533195; DOI=10.1016/0022-1759(94)00288-8;
van den Berg C.W., Harrison R.A., Morgan B.P.;
"A rapid method for the isolation of analogues of human CD59 by
preparative SDS-PAGE: application to pig CD59.";
J. Immunol. Methods 179:223-231(1995).
-!- FUNCTION: Potent inhibitor of the complement membrane attack
complex (MAC) action. Acts by binding to the C8 and/or C9
complements of the assembling MAC, thereby preventing
incorporation of the multiple copies of C9 required for complete
formation of the osmolytic pore. {ECO:0000269|PubMed:9808497}.
-!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
-!- TISSUE SPECIFICITY: Expressed in all tissues tested (lung, testis
liver, kidney, spleen, heart and skeletal muscle). Highest levels
in lung and spleen, lowest levels in liver and skeletal muscle.
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EMBL; AF020302; AAC67231.1; -; mRNA.
EMBL; AF058328; AAD39837.1; -; mRNA.
RefSeq; NP_999335.1; NM_214170.1.
RefSeq; XP_005661088.1; XM_005661031.2.
UniGene; Ssc.16055; -.
ProteinModelPortal; O62680; -.
SMR; O62680; -.
STRING; 9823.ENSSSCP00000025898; -.
PaxDb; O62680; -.
PeptideAtlas; O62680; -.
PRIDE; O62680; -.
Ensembl; ENSSSCT00000026025; ENSSSCP00000025898; ENSSSCG00000024791.
GeneID; 397347; -.
KEGG; ssc:397347; -.
CTD; 966; -.
eggNOG; ENOG410J39P; Eukaryota.
eggNOG; ENOG410ZEQP; LUCA.
GeneTree; ENSGT00390000016309; -.
HOGENOM; HOG000232180; -.
HOVERGEN; HBG005284; -.
InParanoid; O62680; -.
KO; K04008; -.
OMA; NSDLCNS; -.
OrthoDB; EOG091G11NF; -.
TreeFam; TF338524; -.
Reactome; R-SSC-204005; COPII (Coat Protein 2) Mediated Vesicle Transport.
Reactome; R-SSC-5694530; Cargo concentration in the ER.
Reactome; R-SSC-6798695; Neutrophil degranulation.
Reactome; R-SSC-6807878; COPI-mediated anterograde transport.
Reactome; R-SSC-977606; Regulation of Complement cascade.
Proteomes; UP000008227; Chromosome 2.
Bgee; ENSSSCG00000024791; -.
Genevisible; O62680; SS.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0009986; C:cell surface; IBA:GO_Central.
GO; GO:0005576; C:extracellular region; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0001848; F:complement binding; IBA:GO_Central.
GO; GO:0001775; P:cell activation; IBA:GO_Central.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IDA:AgBase.
GO; GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:InterPro.
GO; GO:0030449; P:regulation of complement activation; IBA:GO_Central.
InterPro; IPR018363; CD59_antigen_CS.
InterPro; IPR027101; CD59_glyco.
InterPro; IPR016054; LY6_UPA_recep-like.
PANTHER; PTHR10036:SF9; PTHR10036:SF9; 1.
SMART; SM00134; LU; 1.
PROSITE; PS00983; LY6_UPAR; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
Reference proteome; Signal.
SIGNAL 1 25 {ECO:0000269|PubMed:7533195}.
CHAIN 26 98 CD59 glycoprotein.
/FTId=PRO_0000036118.
PROPEP 99 123 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000036119.
DOMAIN 26 103 UPAR/Ly6.
LIPID 98 98 GPI-anchor amidated serine.
{ECO:0000250}.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 28 51 {ECO:0000250}.
DISULFID 31 38 {ECO:0000250}.
DISULFID 44 65 {ECO:0000250}.
DISULFID 71 89 {ECO:0000250}.
DISULFID 90 95 {ECO:0000250}.
CONFLICT 26 26 L -> M (in Ref. 2; AAD39837).
{ECO:0000305}.
CONFLICT 46 46 H -> Y (in Ref. 3; AA sequence).
{ECO:0000305}.
CONFLICT 63 63 Missing (in Ref. 3; AA sequence).
{ECO:0000305}.
SEQUENCE 123 AA; 13790 MW; FD62ED3F93C91321 CRC64;
MGSKGGFILL WLLSILAVLC HLGHSLQCYN CINPAGSCTT AMNCSHNQDA CIFVEAVPPK
TYYQCWRFDE CNFDFISRNL AEKKLKYNCC RKDLCNKSDA TISSGKTALL VILLLVATWH
FCL


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