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CD59 glycoprotein (MAC-inhibitory protein) (MAC-IP) (Membrane attack complex inhibition factor) (MACIF) (Protectin) (CD antigen CD59)

 CD59_MACFA              Reviewed;         128 AA.
Q8SQ46; Q4R5M6; Q8SPI3;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
25-OCT-2017, entry version 68.
RecName: Full=CD59 glycoprotein;
AltName: Full=MAC-inhibitory protein;
Short=MAC-IP;
AltName: Full=Membrane attack complex inhibition factor;
Short=MACIF;
AltName: Full=Protectin;
AltName: CD_antigen=CD59;
Flags: Precursor;
Name=CD59; ORFNames=QccE-13278, QmoA-10351, QnpA-17056;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-72 AND
LEU-96.
TISSUE=Medulla oblongata, and Parietal cortex;
PubMed=11991714; DOI=10.1006/geno.2002.6753;
Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S.,
Hirai M., Hashimoto K.;
"Search for genes positively selected during primate evolution by 5'-
end-sequence screening of cynomolgus monkey cDNAs.";
Genomics 79:657-662(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its
evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Potent inhibitor of the complement membrane attack
complex (MAC) action. Acts by binding to the C8 and/or C9
complements of the assembling MAC, thereby preventing
incorporation of the multiple copies of C9 required for complete
formation of the osmolytic pore (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with T-cell surface antigen CD2. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor,
GPI-anchor {ECO:0000250}.
-!- PTM: N- and O-glycosylated. {ECO:0000250}.
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EMBL; AB072017; BAB86806.1; -; mRNA.
EMBL; AB072018; BAB86807.1; -; mRNA.
EMBL; AB169517; BAE01599.1; -; mRNA.
RefSeq; XP_015289596.1; XM_015434110.1.
UniGene; Mfa.6139; -.
ProteinModelPortal; Q8SQ46; -.
SMR; Q8SQ46; -.
GeneID; 101867071; -.
CTD; 966; -.
HOVERGEN; HBG005284; -.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:InterPro.
InterPro; IPR018363; CD59_antigen_CS.
InterPro; IPR027101; CD59_glyco.
InterPro; IPR016054; LY6_UPA_recep-like.
PANTHER; PTHR10036:SF9; PTHR10036:SF9; 1.
Pfam; PF00021; UPAR_LY6; 1.
SMART; SM00134; LU; 1.
PROSITE; PS00983; LY6_UPAR; 1.
2: Evidence at transcript level;
Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
Membrane; Polymorphism; Signal.
SIGNAL 1 25 {ECO:0000250}.
CHAIN 26 102 CD59 glycoprotein.
/FTId=PRO_0000036110.
PROPEP 103 128 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000036111.
DOMAIN 26 108 UPAR/Ly6.
LIPID 102 102 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 28 51 {ECO:0000250}.
DISULFID 31 38 {ECO:0000250}.
DISULFID 44 64 {ECO:0000250}.
DISULFID 70 88 {ECO:0000250}.
DISULFID 89 94 {ECO:0000250}.
VARIANT 72 72 Y -> F. {ECO:0000269|PubMed:11991714}.
VARIANT 96 96 F -> L. {ECO:0000269|PubMed:11991714}.
SEQUENCE 128 AA; 14008 MW; 8867D956D63F6E52 CRC64;
MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTTDCKT AINCSSGFDT CLIARAGLQV
YNQCWKFANC NYNDISTLLK ESELRYFCCK KDLCNFNEQL ESGGTSLSEK TVVLLVTPLL
AAAWCLHP


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