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CD74 antigen (Invariant polypeptide of major histocompatibility complex, class II antigen-associated), isoform CRA_f

 Q3U4Q8_MOUSE            Unreviewed;       279 AA.
Q3U4Q8;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
25-OCT-2017, entry version 112.
SubName: Full=CD74 antigen (Invariant polypeptide of major histocompatibility complex, class II antigen-associated), isoform CRA_f {ECO:0000313|EMBL:EDL09810.1};
Name=Cd74 {ECO:0000313|EMBL:EDL09810.1, ECO:0000313|MGI:MGI:96534};
Synonyms=Ii {ECO:0000313|MGI:MGI:96534};
ORFNames=mCG_6027 {ECO:0000313|EMBL:EDL09810.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE32373.1};
[1] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to
prepare full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format
sequencing pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[6] {ECO:0000313|EMBL:EDL09810.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL09810.1};
PubMed=12040188; DOI=10.1126/science.1069193;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and
the human genome.";
Science 296:1661-1671(2002).
[7] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
Muramatsu M., Hayashizaki Y.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[9] {ECO:0000313|EMBL:BAE32373.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NOD {ECO:0000313|EMBL:BAE32373.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
[10] {ECO:0000313|EMBL:EDL09810.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL09810.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
-----------------------------------------------------------------------
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EMBL; AK154096; BAE32373.1; -; mRNA.
EMBL; CH466528; EDL09810.1; -; Genomic_DNA.
RefSeq; NP_001036070.1; NM_001042605.1.
UniGene; Mm.439737; -.
GeneID; 16149; -.
KEGG; mmu:16149; -.
CTD; 972; -.
MGI; MGI:96534; Cd74.
eggNOG; ENOG410IY5J; Eukaryota.
eggNOG; ENOG410Z4PR; LUCA.
HOVERGEN; HBG004444; -.
KO; K06505; -.
OMA; KCSRGAL; -.
OrthoDB; EOG091G0FT7; -.
ChiTaRS; Cd74; mouse.
Bgee; ENSMUSG00000024610; -.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:0035692; C:macrophage migration inhibitory factor receptor complex; IEA:Ensembl.
GO; GO:0042613; C:MHC class II protein complex; IEA:Ensembl.
GO; GO:0005771; C:multivesicular body; IEA:Ensembl.
GO; GO:0035693; C:NOS2-CD74 complex; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
GO; GO:0004896; F:cytokine receptor activity; IEA:Ensembl.
GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:Ensembl.
GO; GO:0042658; F:MHC class II protein binding, via antigen binding groove; IEA:Ensembl.
GO; GO:0050998; F:nitric-oxide synthase binding; IEA:Ensembl.
GO; GO:0044183; F:protein binding involved in protein folding; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0051085; P:chaperone mediated protein folding requiring cofactor; IEA:Ensembl.
GO; GO:0006952; P:defense response; IEA:Ensembl.
GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO; GO:0035691; P:macrophage migration inhibitory factor signaling pathway; IEA:Ensembl.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; IEA:Ensembl.
GO; GO:0002792; P:negative regulation of peptide secretion; IEA:Ensembl.
GO; GO:0045581; P:negative regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Ensembl.
GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
GO; GO:0045657; P:positive regulation of monocyte differentiation; IEA:Ensembl.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0002830; P:positive regulation of type 2 immune response; IEA:Ensembl.
GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IEA:Ensembl.
GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
GO; GO:0051290; P:protein heterotetramerization; IEA:Ensembl.
GO; GO:0070206; P:protein trimerization; IEA:InterPro.
Gene3D; 1.10.870.10; -; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
InterPro; IPR022339; MHC_II-assoc_invar_chain.
InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
InterPro; IPR036613; MHCII_invariant_trimer_sf.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
Pfam; PF09307; MHC2-interact; 1.
Pfam; PF08831; MHCassoc_trimer; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
PRINTS; PR01990; CD74ANTIGEN.
SMART; SM00211; TY; 1.
SUPFAM; SSF48305; SSF48305; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00500,
ECO:0000256|SAAS:SAAS00485231}; Membrane {ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 30 55 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 193 254 Thyroglobulin type-1.
{ECO:0000259|PROSITE:PS51162}.
DISULFID 196 215 {ECO:0000256|PROSITE-ProRule:PRU00500}.
DISULFID 226 233 {ECO:0000256|PROSITE-ProRule:PRU00500}.
SEQUENCE 279 AA; 31557 MW; 300A85014F170792 CRC64;
MDDQRDLISN HEQLPILGNR PREPERCSRG ALYTGVSVLV ALLLAGQATT AYFLYQQQGR
LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM
TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL
EEKKPTEAPP KVLTKCQEEV SHIPAVYPGA FRPKCDENGN YLPLQCHGST GYCWCVFPNG
TEVPHTKSRG RHNCSEPLDM EDLSSGLGVT RQELGQVTL


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