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CD74 molecule (CD74 molecule, major histocompatibility complex, class II invariant chain) (Invariant chain) (Invariant gamma chain)

 Q29630_BOVIN            Unreviewed;       204 AA.
Q29630; F1MXK0;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 121.
SubName: Full=CD74 molecule {ECO:0000313|Ensembl:ENSBTAP00000020261};
SubName: Full=CD74 molecule, major histocompatibility complex, class II invariant chain {ECO:0000313|EMBL:AAI02389.1};
SubName: Full=Invariant chain {ECO:0000313|EMBL:BAA12156.1};
SubName: Full=Invariant gamma chain {ECO:0000313|EMBL:AAX46336.1};
Name=CD74 {ECO:0000313|EMBL:AAI02389.1,
ECO:0000313|Ensembl:ENSBTAP00000020261};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:BAA12156.1};
[1] {ECO:0000313|EMBL:BAA12156.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Japanese Black {ECO:0000313|EMBL:BAA12156.1};
TISSUE=Tumorus lymph node {ECO:0000313|EMBL:BAA12156.1};
PubMed=8630076; DOI=10.1006/bbrc.1996.0689;
Niimi M., Nakai Y., Aida Y.;
"Identification of bovine invariant chain (Ii) gene by nucleotide
sequencing.";
Biochem. Biophys. Res. Commun. 222:7-12(1996).
[2] {ECO:0000313|EMBL:AAX46336.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Pooled {ECO:0000313|EMBL:AAX46336.1};
PubMed=12140684; DOI=10.1007/s00335-001-2145-4;
Sonstegard T.S., Capuco A.V., White J., Van Tassell C.P., Connor E.E.,
Cho J., Sultana R., Shade L., Wray J.E., Wells K.D., Quackenbush J.;
"Analysis of bovine mammary gland EST and functional annotation of the
Bos taurus gene index.";
Mamm. Genome 13:373-379(2002).
[3] {ECO:0000313|EMBL:AAX46336.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Pooled {ECO:0000313|EMBL:AAX46336.1};
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[4] {ECO:0000313|EMBL:AAI02389.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI02389.1};
TISSUE=Ileum {ECO:0000313|EMBL:AAI02389.1};
Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
Siddiqui A., Holt R., Jones S.J., Marra M.A.;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|Ensembl:ENSBTAP00000020261, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020261,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[6] {ECO:0000313|Ensembl:ENSBTAP00000020261}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020261};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
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EMBL; DAAA02020627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC102388; AAI02389.1; -; mRNA.
EMBL; BT021489; AAX46336.1; -; mRNA.
EMBL; D83962; BAA12156.1; -; mRNA.
PIR; JC4796; JC4796.
RefSeq; NP_001029907.1; NM_001034735.1.
UniGene; Bt.46809; -.
STRING; 9913.ENSBTAP00000020261; -.
Ensembl; ENSBTAT00000020261; ENSBTAP00000020261; ENSBTAG00000015228.
GeneID; 613384; -.
KEGG; bta:613384; -.
CTD; 972; -.
eggNOG; ENOG410IY5J; Eukaryota.
eggNOG; ENOG410Z4PR; LUCA.
GeneTree; ENSGT00390000008961; -.
HOGENOM; HOG000013145; -.
HOVERGEN; HBG004444; -.
KO; K06505; -.
OMA; KCSRGAL; -.
OrthoDB; EOG091G0FT7; -.
TreeFam; TF317779; -.
Reactome; R-BTA-202733; Cell surface interactions at the vascular wall.
Reactome; R-BTA-2132295; MHC class II antigen presentation.
Proteomes; UP000009136; Chromosome 7.
Bgee; ENSBTAG00000015228; -.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:0035692; C:macrophage migration inhibitory factor receptor complex; IEA:Ensembl.
GO; GO:0042613; C:MHC class II protein complex; IEA:Ensembl.
GO; GO:0005771; C:multivesicular body; IEA:Ensembl.
GO; GO:0035693; C:NOS2-CD74 complex; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
GO; GO:0004896; F:cytokine receptor activity; IEA:Ensembl.
GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:Ensembl.
GO; GO:0042658; F:MHC class II protein binding, via antigen binding groove; IEA:Ensembl.
GO; GO:0050998; F:nitric-oxide synthase binding; IEA:Ensembl.
GO; GO:0044183; F:protein binding involved in protein folding; IEA:Ensembl.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0051085; P:chaperone mediated protein folding requiring cofactor; IEA:Ensembl.
GO; GO:0006952; P:defense response; IEA:Ensembl.
GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO; GO:0035691; P:macrophage migration inhibitory factor signaling pathway; IEA:Ensembl.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; IEA:Ensembl.
GO; GO:0002792; P:negative regulation of peptide secretion; IEA:Ensembl.
GO; GO:0045581; P:negative regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Ensembl.
GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0033674; P:positive regulation of kinase activity; IEA:Ensembl.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
GO; GO:0045657; P:positive regulation of monocyte differentiation; IEA:Ensembl.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0002830; P:positive regulation of type 2 immune response; IEA:Ensembl.
GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IEA:Ensembl.
GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
GO; GO:0051290; P:protein heterotetramerization; IEA:Ensembl.
GO; GO:0070206; P:protein trimerization; IEA:InterPro.
Gene3D; 1.10.870.10; -; 1.
InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
InterPro; IPR022339; MHC_II-assoc_invar_chain.
InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
InterPro; IPR036613; MHCII_invariant_trimer_sf.
Pfam; PF09307; MHC2-interact; 1.
Pfam; PF08831; MHCassoc_trimer; 1.
PRINTS; PR01990; CD74ANTIGEN.
SUPFAM; SSF48305; SSF48305; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 32 56 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 1 105 MHC2-interact.
{ECO:0000259|Pfam:PF09307}.
DOMAIN 118 185 MHCassoc_trimer.
{ECO:0000259|Pfam:PF08831}.
SEQUENCE 204 AA; 23146 MW; 0FD00643BCA82BFA CRC64;
MEDQRDLISN HEQLPMLGQR PGAQESKCSR GALYTGFSVL VALLLAGQAT TAYFLYQQQG
RLDKLTVTSQ NLQLENLRMK LPKPAKPMSQ MRMATPMLMR ALPMAGPEPM KNATKYGNMT
QDHVMHLLLK ADPLKVYPQL KGSLPENLKH LKDSMDGLDW KLFESWLHQW LLFEMSKNSL
EEKPFEGPPK DPMEMEYPSS GLGV


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