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CD74 molecule (Invariant chain isoform p41)

 Q6J613_CHICK            Unreviewed;       286 AA.
Q6J613;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
22-NOV-2017, entry version 107.
SubName: Full=CD74 molecule {ECO:0000313|Ensembl:ENSGALP00000007299};
SubName: Full=Invariant chain isoform p41 {ECO:0000313|EMBL:AAT36346.1};
Name=Ii {ECO:0000313|EMBL:AAT36346.1};
Synonyms=CD74 {ECO:0000313|Ensembl:ENSGALP00000007299};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1] {ECO:0000313|EMBL:AAT36346.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Spleen {ECO:0000313|EMBL:AAT36346.1};
PubMed=15578263; DOI=10.1007/s00251-004-0726-6;
Zhong D., Yu W., Liu Y., Liu J., Li J.;
"Molecular cloning and expression of two chicken invariant chain
isoforms produced by alternative splicing.";
Immunogenetics 56:650-656(2004).
[2] {ECO:0000313|Ensembl:ENSGALP00000007299, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000007299,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[3] {ECO:0000313|Ensembl:ENSGALP00000007299}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000007299};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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EMBL; AADN04000140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY597054; AAT36346.1; -; mRNA.
RefSeq; NP_001001613.1; NM_001001613.1.
UniGene; Gga.4414; -.
STRING; 9031.ENSGALP00000007299; -.
Ensembl; ENSGALT00000007311; ENSGALP00000007299; ENSGALG00000004594.
GeneID; 414741; -.
CTD; 972; -.
eggNOG; ENOG410IMYV; Eukaryota.
eggNOG; ENOG4111R03; LUCA.
GeneTree; ENSGT00390000008961; -.
HOVERGEN; HBG004444; -.
OMA; KCSRGAL; -.
OrthoDB; EOG091G0FT7; -.
TreeFam; TF317779; -.
Reactome; R-GGA-202733; Cell surface interactions at the vascular wall.
Reactome; R-GGA-2132295; MHC class II antigen presentation.
Proteomes; UP000000539; Chromosome 13.
Bgee; ENSGALG00000004594; -.
ExpressionAtlas; Q6J613; baseline and differential.
GO; GO:0009986; C:cell surface; IDA:AgBase.
GO; GO:0005737; C:cytoplasm; IDA:AgBase.
GO; GO:0005783; C:endoplasmic reticulum; IDA:AgBase.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IDA:AgBase.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:0035692; C:macrophage migration inhibitory factor receptor complex; IEA:Ensembl.
GO; GO:0042613; C:MHC class II protein complex; IEA:Ensembl.
GO; GO:0042611; C:MHC protein complex; IDA:AgBase.
GO; GO:0005771; C:multivesicular body; IEA:Ensembl.
GO; GO:0035693; C:NOS2-CD74 complex; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
GO; GO:0004896; F:cytokine receptor activity; IEA:Ensembl.
GO; GO:0035718; F:macrophage migration inhibitory factor binding; IDA:AgBase.
GO; GO:0042288; F:MHC class I protein binding; IPI:AgBase.
GO; GO:0042658; F:MHC class II protein binding, via antigen binding groove; IEA:Ensembl.
GO; GO:0050998; F:nitric-oxide synthase binding; IEA:Ensembl.
GO; GO:0044183; F:protein binding involved in protein folding; IEA:Ensembl.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0051085; P:chaperone mediated protein folding requiring cofactor; IEA:Ensembl.
GO; GO:0006952; P:defense response; IEA:Ensembl.
GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO; GO:0035691; P:macrophage migration inhibitory factor signaling pathway; IEA:Ensembl.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; IEA:Ensembl.
GO; GO:0002792; P:negative regulation of peptide secretion; IEA:Ensembl.
GO; GO:0045581; P:negative regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Ensembl.
GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0033674; P:positive regulation of kinase activity; IEA:Ensembl.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
GO; GO:0045657; P:positive regulation of monocyte differentiation; IEA:Ensembl.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0002830; P:positive regulation of type 2 immune response; IEA:Ensembl.
GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IEA:Ensembl.
GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
GO; GO:0051290; P:protein heterotetramerization; IEA:Ensembl.
GO; GO:0070206; P:protein trimerization; IEA:InterPro.
Gene3D; 1.10.870.10; -; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
InterPro; IPR022339; MHC_II-assoc_invar_chain.
InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
InterPro; IPR036613; MHCII_invariant_trimer_sf.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
Pfam; PF09307; MHC2-interact; 1.
Pfam; PF08831; MHCassoc_trimer; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
PRINTS; PR01990; CD74ANTIGEN.
SMART; SM00211; TY; 1.
SUPFAM; SSF48305; SSF48305; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000539};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00500,
ECO:0000256|SAAS:SAAS00485231}; Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 33 56 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 199 259 Thyroglobulin type-1.
{ECO:0000259|PROSITE:PS51162}.
DISULFID 231 238 {ECO:0000256|PROSITE-ProRule:PRU00500}.
SEQUENCE 286 AA; 31753 MW; 87E3F10E0D5DFA5D CRC64;
MAEEQRDLIS SDGSSGVLPI GNSERSSLGR RTALSALSIL VALLIAGQAV TIYYVYQQSG
QISKLTKTSQ TLKLESLQRK MPIGTQPANK MSMSTMNMPM AMKVLPLAPS VGDMPMEAMK
PRSNKTEDQI RHLLLKSDPR KTFPDLKDDM LGNLKRLKKT MSAMDWQDFE TWMHKWLLFE
MAKGPKMEEQ NTIPAEKVQT KCQAEASFGG VHPGRFRPEC DENGDYLPKQ CYASTGYCWC
CYKNGTRIEG TATRGQLDCS APAPTQPPSA EPEEVIFSGV DMVKAK


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