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CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (CD antigen CD81)

 CD81_RAT                Reviewed;         236 AA.
Q62745;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
05-DEC-2018, entry version 132.
RecName: Full=CD81 antigen;
AltName: Full=26 kDa cell surface protein TAPA-1;
AltName: Full=Target of the antiproliferative antibody 1;
AltName: CD_antigen=CD81;
Name=Cd81; Synonyms=Tapa1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Brain cortex;
PubMed=8757260;
Geisert E.E. Jr., Yang L., Irwin M.H.;
"Astrocyte growth, reactivity, and the target of the antiproliferative
antibody, TAPA.";
J. Neurosci. 16:5478-5487(1996).
[2]
PROTEIN SEQUENCE OF 125-144; 172-187 AND 194-201, AND IDENTIFICATION
BY MASS SPECTROMETRY.
STRAIN=Sprague-Dawley; TISSUE=Brain;
Lubec G., Kang S.U., Lubec S.;
Submitted (SEP-2007) to UniProtKB.
-!- FUNCTION: May be involved in the acrosome reaction.
{ECO:0000250|UniProtKB:P35762}.
-!- SUBUNIT: Homodimer. Interacts directly with IGSF8. Interacts with
CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of
a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81,
eventually CD9, and GNA11 in which CD81 enhances the association
of ADGRG1 with GNA11. Interacts with CLDN1, CLDN6 and CLDN9.
Interacts (via the second extracellular domain) with integrin
ITGAV:ITGB3. Interacts with glypican GPC3 and with transcriptional
repressor HHEX; binding to GPC3 decreases the availability of free
CD81 for binding to HHEX, resulting in nuclear translocation of
HHEX and transcriptional repression.
{ECO:0000250|UniProtKB:P35762, ECO:0000250|UniProtKB:P60033}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P35762}; Multi-pass membrane protein
{ECO:0000255}. Basolateral cell membrane
{ECO:0000250|UniProtKB:P60033}; Multi-pass membrane protein
{ECO:0000255}. Note=Associates with CLDN1 and the CLDN1-CD81
complex localizes to the basolateral cell membrane.
{ECO:0000250|UniProtKB:P60033}.
-!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
{ECO:0000305}.
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EMBL; U19894; AAC53103.1; -; mRNA.
UniGene; Rn.1975; -.
ProteinModelPortal; Q62745; -.
SMR; Q62745; -.
BioGrid; 247650; 1.
STRING; 10116.ENSRNOP00000027760; -.
iPTMnet; Q62745; -.
PhosphoSitePlus; Q62745; -.
SwissPalm; Q62745; -.
PaxDb; Q62745; -.
PRIDE; Q62745; -.
UCSC; RGD:2315; rat.
RGD; 2315; Cd81.
eggNOG; KOG3882; Eukaryota.
eggNOG; ENOG4111IRY; LUCA.
HOGENOM; HOG000230651; -.
HOVERGEN; HBG002324; -.
InParanoid; Q62745; -.
PhylomeDB; Q62745; -.
PRO; PR:Q62745; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; ISS:UniProtKB.
GO; GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0008104; P:protein localization; ISS:UniProtKB.
GO; GO:0031623; P:receptor internalization; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; IDA:RGD.
GO; GO:0040008; P:regulation of growth; IEP:RGD.
GO; GO:0009611; P:response to wounding; IEP:RGD.
Gene3D; 1.10.1450.10; -; 1.
InterPro; IPR000301; Tetraspanin.
InterPro; IPR018499; Tetraspanin/Peripherin.
InterPro; IPR018503; Tetraspanin_CS.
InterPro; IPR008952; Tetraspanin_EC2_sf.
Pfam; PF00335; Tetraspanin; 1.
PIRSF; PIRSF002419; Tetraspanin; 1.
PRINTS; PR00259; TMFOUR.
SUPFAM; SSF48652; SSF48652; 1.
PROSITE; PS00421; TM4_1; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Direct protein sequencing;
Disulfide bond; Membrane; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN 1 236 CD81 antigen.
/FTId=PRO_0000219224.
TOPO_DOM 1 12 Cytoplasmic. {ECO:0000255}.
TRANSMEM 13 33 Helical. {ECO:0000255}.
TOPO_DOM 34 57 Extracellular. {ECO:0000255}.
TRANSMEM 58 78 Helical. {ECO:0000255}.
TOPO_DOM 79 89 Cytoplasmic. {ECO:0000255}.
TRANSMEM 90 115 Helical. {ECO:0000255}.
TOPO_DOM 116 201 Extracellular. {ECO:0000255}.
TRANSMEM 202 226 Helical. {ECO:0000255}.
TOPO_DOM 227 236 Cytoplasmic. {ECO:0000255}.
SITE 116 116 Important for interaction with integrin.
{ECO:0000250|UniProtKB:P60033}.
SITE 144 144 Important for interaction with integrin.
{ECO:0000250|UniProtKB:P60033}.
SITE 148 148 Important for interaction with integrin.
{ECO:0000250|UniProtKB:P60033}.
DISULFID 156 190 {ECO:0000250}.
DISULFID 157 175 {ECO:0000250}.
SEQUENCE 236 AA; 25889 MW; DCC48F38EB19BDF5 CRC64;
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTTLLYLELG DKPAPSTFYV
GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA
KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF HETLNCCGSN TLTTLTTAVL RNSLCPSSSN
SFTQLLKEDC HQKIDELFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY


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