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CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99)

 C99L2_MOUSE             Reviewed;         237 AA.
Q8BIF0; A2AP77; Q8R447;
10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
05-JUL-2017, entry version 106.
RecName: Full=CD99 antigen-like protein 2;
AltName: Full=MIC2-like protein 1;
AltName: CD_antigen=CD99;
Flags: Precursor;
Name=Cd99l2; Synonyms=Mic2l1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, AND
TISSUE SPECIFICITY.
PubMed=12706889; DOI=10.1016/S0378-1119(03)00401-3;
Suh Y.H., Shin Y.K., Kook M.-C., Oh K.I., Park W.S., Kim S.H.,
Lee I.-S., Park H.J., Huh T.-L., Park S.H.;
"Cloning, genomic organization, alternative transcripts and expression
analysis of CD99L2, a novel paralog of human CD99, and identification
of evolutionary conserved motifs.";
Gene 307:63-76(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Thymus;
PubMed=18163232; DOI=10.1080/15419060701755966;
Schenkel A.R., Dufour E.M., Chew T.W., Sorg E., Muller W.A.;
"The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion
molecule involved in the inflammatory response.";
Cell Commun. Adhes. 14:227-237(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Aorta, and Mammary gland;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
PubMed=17344467; DOI=10.1182/blood-2006-08-043109;
Bixel M.G., Petri B., Khandoga A.G., Khandoga A., Wolburg-Buchholz K.,
Wolburg H., Marz S., Krombach F., Vestweber D.;
"A CD99-related antigen on endothelial cells mediates neutrophil but
not lymphocyte extravasation in vivo.";
Blood 109:5327-5336(2007).
[7]
FUNCTION.
PubMed=20479283; DOI=10.1182/blood-2009-12-256388;
Bixel M.G., Li H., Petri B., Khandoga A.G., Khandoga A., Zarbock A.,
Wolburg-Buchholz K., Wolburg H., Sorokin L., Zeuschner D., Maerz S.,
Butz S., Krombach F., Vestweber D.;
"CD99 and CD99L2 act at the same site as, but independently of, PECAM-
1 during leukocyte diapedesis.";
Blood 116:1172-1184(2010).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, and Lung;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plays a role in a late step of leukocyte extravasation
helping cells to overcome the endothelial basement membrane. Acts
at the same site as, but independently of, PECAM1. Homophilic
adhesion molecule, but these interactions may not be required for
cell aggregation. {ECO:0000269|PubMed:17344467,
ECO:0000269|PubMed:18163232, ECO:0000269|PubMed:20479283}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}; Extracellular side
{ECO:0000250}. Cell junction {ECO:0000269|PubMed:17344467}.
Note=Concentrated at cell-cell contacts in cultured endothelial
cells.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Long isoform;
IsoId=Q8BIF0-1; Sequence=Displayed;
Name=2; Synonyms=Short isoform;
IsoId=Q8BIF0-2; Sequence=VSP_034186;
Note=Seems to be the major transcript.;
-!- TISSUE SPECIFICITY: Highly expressed in the nervous system,
including brain, dentate nucleus of hippocampus, granular and
Purkinje cells of cerebellum, brain stem nucleus and choroid
plexus. Expressed in peripheral blood T- and B-cells and
neutrophils (at protein level). Almost undetectable in bone
marrow-derived neutrophils (at protein level). Also expressed in
thymocytes (at protein level) with higher expression in cortical
thymocytes than in medullary thymocytes. Expressed at high levels
in testis (mostly in germ cells and Sertoli cells) and ovary
(mostly in granulosa cells). Expressed in lung, heart, kidney and
liver (at protein level); however, expression in heart, kidney and
liver seems restricted to endothelial cells (at protein level).
Highly expressed in endothelial cells and to a lower level in
vascular smooth muscle cells (at protein level). Low expression in
spleen. {ECO:0000269|PubMed:12706889, ECO:0000269|PubMed:17344467,
ECO:0000269|PubMed:18163232}.
-!- DEVELOPMENTAL STAGE: At 12.5 dpc, expressed in most tissues,
especially in the nervous system, including the cerebral cortex,
cerebellum, spinal cord and ganglion. There is no change in
expression pattern from 12.5 dpc to neonatal day 1. Highly
expressed in the subventricular zone and cortical plate of fetal
brain and in the dorsal root ganglion of the peripheral nervous
system. Except in the nervous system, expression in adult tissues
is weaker than in fetal ones.
-!- PTM: O-glycosylated. {ECO:0000269|PubMed:17344467}.
-!- SIMILARITY: Belongs to the CD99 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAM25451.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AY078163; AAL86615.1; -; mRNA.
EMBL; EF516990; ABP73253.1; -; mRNA.
EMBL; AK080225; BAC37853.1; -; mRNA.
EMBL; AK166275; BAE38674.1; -; mRNA.
EMBL; AL833776; CAM25449.1; -; Genomic_DNA.
EMBL; AL772294; CAM25449.1; JOINED; Genomic_DNA.
EMBL; AL833776; CAM25450.1; -; Genomic_DNA.
EMBL; AL772294; CAM25450.1; JOINED; Genomic_DNA.
EMBL; AL833776; CAM25451.1; ALT_SEQ; Genomic_DNA.
EMBL; AL772294; CAM25451.1; JOINED; Genomic_DNA.
EMBL; BC031736; AAH31736.1; -; mRNA.
CCDS; CCDS30179.1; -. [Q8BIF0-2]
CCDS; CCDS57761.1; -. [Q8BIF0-1]
RefSeq; NP_001186278.1; NM_001199349.1. [Q8BIF0-1]
RefSeq; NP_612182.1; NM_138309.3. [Q8BIF0-2]
UniGene; Mm.283879; -.
UniGene; Mm.397118; -.
ProteinModelPortal; Q8BIF0; -.
SMR; Q8BIF0; -.
IntAct; Q8BIF0; 1.
MINT; MINT-4119087; -.
STRING; 10090.ENSMUSP00000042606; -.
iPTMnet; Q8BIF0; -.
PhosphoSitePlus; Q8BIF0; -.
PaxDb; Q8BIF0; -.
PeptideAtlas; Q8BIF0; -.
PRIDE; Q8BIF0; -.
Ensembl; ENSMUST00000037391; ENSMUSP00000042606; ENSMUSG00000035776. [Q8BIF0-1]
Ensembl; ENSMUST00000080035; ENSMUSP00000078944; ENSMUSG00000035776. [Q8BIF0-2]
GeneID; 171486; -.
KEGG; mmu:171486; -.
UCSC; uc009tjz.2; mouse. [Q8BIF0-2]
UCSC; uc009tka.2; mouse. [Q8BIF0-1]
CTD; 83692; -.
MGI; MGI:2177151; Cd99l2.
eggNOG; ENOG410J1MW; Eukaryota.
eggNOG; ENOG410YNQK; LUCA.
GeneTree; ENSGT00530000063944; -.
HOGENOM; HOG000233665; -.
HOVERGEN; HBG067989; -.
InParanoid; Q8BIF0; -.
OMA; LHTQSAE; -.
OrthoDB; EOG091G0YLT; -.
PhylomeDB; Q8BIF0; -.
TreeFam; TF332323; -.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
PRO; PR:Q8BIF0; -.
Proteomes; UP000000589; Chromosome X.
Bgee; ENSMUSG00000035776; -.
ExpressionAtlas; Q8BIF0; baseline and differential.
Genevisible; Q8BIF0; MM.
GO; GO:0005925; C:focal adhesion; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0050900; P:leukocyte migration; TAS:Reactome.
InterPro; IPR022078; CD99L2.
PANTHER; PTHR15076; PTHR15076; 1.
Pfam; PF12301; CD99L2; 1.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Cell junction; Cell membrane;
Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 237 CD99 antigen-like protein 2.
/FTId=PRO_0000340093.
TOPO_DOM 26 161 Extracellular. {ECO:0000255}.
TRANSMEM 162 182 Helical. {ECO:0000255}.
TOPO_DOM 183 237 Cytoplasmic. {ECO:0000255}.
COMPBIAS 74 77 Poly-Thr.
COMPBIAS 142 147 Poly-Gly.
COMPBIAS 229 235 Poly-Pro.
VAR_SEQ 49 71 Missing (in isoform 2).
{ECO:0000303|PubMed:12706889}.
/FTId=VSP_034186.
SEQUENCE 237 AA; 25463 MW; 6876EB515DFA426A CRC64;
MVARLTAFLV CLVFSLATLV QRGYGDTDGF NLEDALKETS SVKQRWDHFS TTTRRPVTTR
APANPAERWD HVATTTTRRP GTTRAPSNPM ELDGFDLEDA LDDRNDLDGP KKPSAGEAGG
WSDKDLEDIV EGGGYKPDKN KGGGGYGSND DPGSGISTET GTIAGVASAL AMALIGAVSS
YISYQQKKFC FSIQQGLNAD YVKGENLEAV VCEEPQVTYS KQETQSAEPP PPEPPRI


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