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CHC1 protein (Regulator of chromosome condensation 1 isoform 1) (Regulator of chromosome condensation 1, isoform CRA_b)

 Q5T081_HUMAN            Unreviewed;       421 AA.
Q5T081;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
28-MAR-2018, entry version 117.
SubName: Full=CHC1 protein {ECO:0000313|EMBL:CAG28621.1};
SubName: Full=Regulator of chromosome condensation 1 isoform 1 {ECO:0000313|EMBL:ALQ33432.1};
SubName: Full=Regulator of chromosome condensation 1, isoform CRA_b {ECO:0000313|EMBL:EAX07693.1};
Name=RCC1 {ECO:0000313|EMBL:EAX07693.1};
Synonyms=CHC1 {ECO:0000313|EMBL:CAG28621.1};
ORFNames=hCG_27809 {ECO:0000313|EMBL:EAX07693.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:EAX07693.1};
[1] {ECO:0000313|EMBL:EAX07693.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:CAG28621.1}
NUCLEOTIDE SEQUENCE.
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:EAX07693.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ALQ33432.1}
NUCLEOTIDE SEQUENCE.
PubMed=26871637; DOI=10.1016/j.cell.2016.01.029;
Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T.,
Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K.,
Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q.,
Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D.,
Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J.,
Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P.,
Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.;
"Widespread Expansion of Protein Interaction Capabilities by
Alternative Splicing.";
Cell 164:805-817(2016).
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EMBL; KU177974; ALQ33432.1; -; mRNA.
EMBL; CR407693; CAG28621.1; -; mRNA.
EMBL; CH471059; EAX07691.1; -; Genomic_DNA.
EMBL; CH471059; EAX07693.1; -; Genomic_DNA.
RefSeq; NP_001041664.1; NM_001048199.2.
RefSeq; NP_001260.1; NM_001269.4.
UniGene; Hs.469723; -.
IntAct; Q5T081; 5.
DNASU; 1104; -.
GeneID; 1104; -.
KEGG; hsa:1104; -.
UCSC; uc001bqb.3; human.
CTD; 1104; -.
EuPathDB; HostDB:ENSG00000180198.15; -.
HOVERGEN; HBG017712; -.
KO; K11493; -.
ChiTaRS; RCC1; human.
GenomeRNAi; 1104; -.
Bgee; ENSG00000180198; -.
GO; GO:0031965; C:nuclear membrane; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
Gene3D; 2.130.10.30; -; 1.
InterPro; IPR009091; RCC1/BLIP-II.
InterPro; IPR000408; Reg_chr_condens.
Pfam; PF00415; RCC1; 7.
PRINTS; PR00633; RCCNDNSATION.
SUPFAM; SSF50985; SSF50985; 1.
PROSITE; PS00625; RCC1_1; 1.
PROSITE; PS00626; RCC1_2; 3.
PROSITE; PS50012; RCC1_3; 7.
2: Evidence at transcript level;
Repeat {ECO:0000256|SAAS:SAAS00507259}.
REPEAT 35 85 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
REPEAT 86 137 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
REPEAT 138 190 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
REPEAT 191 258 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
REPEAT 259 312 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
REPEAT 313 363 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
REPEAT 364 417 RCC1. {ECO:0000256|PROSITE-
ProRule:PRU00235}.
NON_TER 421 421 {ECO:0000313|EMBL:ALQ33432.1}.
SEQUENCE 421 AA; 44969 MW; F6D225AF81928305 CRC64;
MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP
ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK
VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG
NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV
RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS
GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV
TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ
S


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