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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (Alpha 2,3-ST 4) (Beta-galactoside alpha-2,3-sialyltransferase 4) (EC 2.4.99.2) (EC 2.4.99.4) (Alpha 2,3-sialyltransferase IV) (Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase) (ST3Gal IV) (ST3GalIV) (Sialyltransferase 4C) (SIAT4-C)

 SIA4C_RAT               Reviewed;         333 AA.
P61131;
10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
10-MAY-2004, sequence version 1.
23-MAY-2018, entry version 104.
RecName: Full=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4;
Short=Alpha 2,3-ST 4;
Short=Beta-galactoside alpha-2,3-sialyltransferase 4;
EC=2.4.99.2 {ECO:0000250|UniProtKB:Q91Y74};
EC=2.4.99.4 {ECO:0000250|UniProtKB:Q91Y74};
AltName: Full=Alpha 2,3-sialyltransferase IV;
AltName: Full=Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase;
AltName: Full=ST3Gal IV;
Short=ST3GalIV;
AltName: Full=Sialyltransferase 4C;
Short=SIAT4-C;
Name=St3gal4; Synonyms=Siat4c;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P.,
Oriol R.;
"Phylogeny of sialyltransferases.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-
1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences
found in terminal carbohydrate groups of glycoproteins and
glycolipids. It may be involved in the biosynthesis of the sialyl
Lewis X determinant. {ECO:0000250|UniProtKB:Q91Y74}.
-!- CATALYTIC ACTIVITY: CMP-N-acetyl-beta-neuraminate + a beta-D-
galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R = CMP + an N-
acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-
beta-D-galactosaminyl-R. {ECO:0000250|UniProtKB:Q91Y74}.
-!- CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-D-galactosyl-
1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-
acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-
galactosaminyl-R. {ECO:0000250|UniProtKB:Q91Y74}.
-!- PATHWAY: Protein modification; protein glycosylation.
-!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
{ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Note=Membrane-bound form in trans cisternae of Golgi.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
{ECO:0000305}.
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EMBL; AJ626825; CAF25183.1; -; mRNA.
EMBL; BC089057; AAH89057.1; -; mRNA.
RefSeq; NP_976082.1; NM_203337.2.
RefSeq; XP_006242851.1; XM_006242789.3.
RefSeq; XP_008764282.1; XM_008766060.1.
UniGene; Rn.24125; -.
STRING; 10116.ENSRNOP00000013243; -.
SwissLipids; SLP:000001443; -.
CAZy; GT29; Glycosyltransferase Family 29.
PaxDb; P61131; -.
PRIDE; P61131; -.
Ensembl; ENSRNOT00000013243; ENSRNOP00000013243; ENSRNOG00000009850.
GeneID; 363040; -.
KEGG; rno:363040; -.
UCSC; RGD:1303068; rat.
CTD; 6484; -.
RGD; 1303068; St3gal4.
eggNOG; KOG2692; Eukaryota.
eggNOG; ENOG410XT8P; LUCA.
GeneTree; ENSGT00760000119095; -.
HOGENOM; HOG000000682; -.
HOVERGEN; HBG056676; -.
InParanoid; P61131; -.
KO; K03494; -.
OMA; IHYYEQI; -.
OrthoDB; EOG091G098L; -.
PhylomeDB; P61131; -.
TreeFam; TF354325; -.
Reactome; R-RNO-2022854; Keratan sulfate biosynthesis.
Reactome; R-RNO-4085001; Sialic acid metabolism.
Reactome; R-RNO-975577; N-Glycan antennae elongation.
Reactome; R-RNO-977068; Termination of O-glycan biosynthesis.
UniPathway; UPA00378; -.
PRO; PR:P61131; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000009850; -.
Genevisible; P61131; RN.
GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003836; F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0047288; F:monosialoganglioside sialyltransferase activity; IDA:RGD.
GO; GO:0050890; P:cognition; IEA:Ensembl.
GO; GO:0009247; P:glycolipid biosynthetic process; IEA:Ensembl.
GO; GO:0030259; P:lipid glycosylation; IEA:Ensembl.
GO; GO:0009312; P:oligosaccharide biosynthetic process; IEA:Ensembl.
GO; GO:0009311; P:oligosaccharide metabolic process; IBA:GO_Central.
GO; GO:0018279; P:protein N-linked glycosylation via asparagine; IBA:GO_Central.
GO; GO:1990743; P:protein sialylation; IEA:Ensembl.
Gene3D; 3.90.1480.20; -; 1.
InterPro; IPR001675; Glyco_trans_29.
InterPro; IPR038578; GT29-like_sf.
InterPro; IPR012163; Sialyl_trans.
Pfam; PF00777; Glyco_transf_29; 1.
PIRSF; PIRSF005557; Sialyl_trans; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase;
Golgi apparatus; Membrane; Reference proteome; Signal-anchor;
Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 333 CMP-N-acetylneuraminate-beta-
galactosamide-alpha-2,3-sialyltransferase
4.
/FTId=PRO_0000149265.
TOPO_DOM 1 8 Cytoplasmic. {ECO:0000255}.
TRANSMEM 9 26 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 27 333 Lumenal. {ECO:0000255}.
CARBOHYD 61 61 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 131 131 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 310 310 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 329 329 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 120 273 {ECO:0000250}.
SEQUENCE 333 AA; 38043 MW; 8D086A0F73C79791 CRC64;
MTSKSHWKLL ALALVLVVVM VWYSISREDR YIEFFYFPVS EKKEPCFQGE AERQASKIFG
NHSREQPIFL QLKDYFWVKT PSAYELPFGT KGSEDLLLRV LAITSYSIPE SIQSLECRRC
VVVGNGHRLK NSSLGGVINK YDVVIRLNNA PVAGYEGDVG SKTTIRLFYP ESAHFDPKIE
NNPDTLLVLV AFKAMDFHWI ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA
ADKLLSLPIQ QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
LKSMAGSGHN VSQEAVAIKR MLEMGAVKNL TYF


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