Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.99.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)

 SIA8D_CRIGR             Reviewed;         359 AA.
Q64690;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
20-JUN-2018, entry version 78.
RecName: Full=CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase;
EC=2.4.99.-;
AltName: Full=Alpha-2,8-sialyltransferase 8D;
AltName: Full=Polysialyltransferase-1;
AltName: Full=Sialyltransferase 8D;
Short=SIAT8-D;
AltName: Full=Sialyltransferase St8Sia IV;
Short=ST8SiaIV;
Name=ST8SIA4; Synonyms=PST-1, PST1, SIAT8D;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7854457; DOI=10.1038/373715a0;
Eckhardt M., Muehlenhoff M., Bethe A., Koopman J., Frosch M.,
Gerardy-Schahn R.;
"Molecular characterization of eukaryotic polysialyltransferase-1.";
Nature 373:715-718(1995).
-!- FUNCTION: Catalyzes the polycondensation of alpha-2,8-linked
sialic acid required for the synthesis of polysialic acid (PSA),
which is present on the embryonic neural cell adhesion molecule
(N-CAM), necessary for plasticity of neural cells.
-!- PATHWAY: Protein modification; protein glycosylation.
-!- INTERACTION:
Q9BY67:CADM1 (xeno); NbExp=2; IntAct=EBI-15854853, EBI-5652260;
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305};
Single-pass type II membrane protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Z46801; CAA86822.1; -; mRNA.
PIR; S52425; S52425.
RefSeq; NP_001231179.1; NM_001244250.1.
SMR; Q64690; -.
DIP; DIP-59529N; -.
IntAct; Q64690; 2.
CAZy; GT29; Glycosyltransferase Family 29.
PRIDE; Q64690; -.
GeneID; 100689217; -.
KEGG; cge:100689217; -.
CTD; 7903; -.
HOVERGEN; HBG056466; -.
KO; K06614; -.
UniPathway; UPA00378; -.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003828; F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; IEA:Ensembl.
GO; GO:0001574; P:ganglioside biosynthetic process; IEA:Ensembl.
GO; GO:0006491; P:N-glycan processing; IEA:Ensembl.
GO; GO:0009311; P:oligosaccharide metabolic process; IEA:Ensembl.
GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
Gene3D; 3.90.1480.20; -; 1.
InterPro; IPR001675; Glyco_trans_29.
InterPro; IPR038578; GT29-like_sf.
InterPro; IPR012163; Sialyl_trans.
Pfam; PF00777; Glyco_transf_29; 1.
PIRSF; PIRSF005557; Sialyl_trans; 1.
1: Evidence at protein level;
Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus;
Membrane; Signal-anchor; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 359 CMP-N-acetylneuraminate-poly-alpha-2,8-
sialyltransferase.
/FTId=PRO_0000149292.
TOPO_DOM 1 7 Cytoplasmic. {ECO:0000255}.
TRANSMEM 8 20 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 21 359 Lumenal. {ECO:0000255}.
REGION 191 193 Substrate binding.
{ECO:0000250|UniProtKB:O43173}.
REGION 279 281 Substrate binding.
{ECO:0000250|UniProtKB:O43173}.
REGION 314 315 Substrate binding.
{ECO:0000250|UniProtKB:O43173}.
ACT_SITE 331 331 Proton donor/acceptor.
{ECO:0000250|UniProtKB:O43173}.
BINDING 170 170 Substrate.
{ECO:0000250|UniProtKB:O43173}.
CARBOHYD 50 50 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 74 74 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 119 119 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 219 219 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 142 292 {ECO:0000250|UniProtKB:O43173}.
DISULFID 156 356 {ECO:0000250|UniProtKB:O43173}.
SEQUENCE 359 AA; 41227 MW; C31AF4C27F8A336F CRC64;
MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELCLSRSLVN SSDKIIRKAG
STIFQHSVQG WRINSSLVLE IRKNILRFLD AERDVSVVKS SFKPGDVIHY VLDRRRTLNI
SHDLHSLLPE VSPMKNRRFK TCAVVGNSGI LLDSGCGKEI DSHNFVIRCN LAPVVEFAAD
VGTKSDFITM NPSVVQRAFG GFRNESDRAK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV
NALILKNKLK VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF
WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK LTTGKCMKQ


Related products :

Catalog number Product name Quantity
EIAAB38410 Alpha-2,8-sialyltransferase 8D,CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase,Mouse,Mus musculus,Polysialyltransferase-1,Pst,Sialyltransferase 8D,Sialytransferase St8Sia IV,Siat8d,SIAT8-D,St
EIAAB38411 Alpha-2,8-sialyltransferase 8D,Bos taurus,Bovine,CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase,Polysialyltransferase-1,Sialyltransferase 8D,Sialytransferase St8Sia IV,SIAT8D,SIAT8-D,ST8SIA4
EIAAB38412 Alpha-2,8-sialyltransferase 8D,CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase,Homo sapiens,Human,Polysialyltransferase-1,PST,PST1,Sialyltransferase 8D,Sialytransferase St8Sia IV,SIAT8D,SIAT8
EIAAB38408 Alpha-2,8-sialyltransferase 8C,Alpha-2,8-sialyltransferase III,Homo sapiens,Human,Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R alpha 2,8-sialyltransferase,Sialyltransferase 8C,Sialytransferase St8Sia III,SIAT8
EIAAB38409 Alpha-2,8-sialyltransferase 8C,Alpha-2,8-sialyltransferase III,Mouse,Mus musculus,Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R alpha 2,8-sialyltransferase,Sialyltransferase 8C,Sialytransferase St8Sia III,Siat8
EIAAB38406 Alpha-2,8-sialyltransferase 8B,Rat,Rattus norvegicus,Sialyltransferase 8B,Sialyltransferase X,Sialytransferase St8Sia II,Siat8b,SIAT8-B,St8sia2,ST8SiaII,STX,Stx
EIAAB38405 Alpha-2,8-sialyltransferase 8B,Homo sapiens,Human,Sialyltransferase 8B,Sialyltransferase X,Sialytransferase St8Sia II,SIAT8B,SIAT8-B,ST8SIA2,ST8SiaII,STX,STX
EIAAB38407 Alpha-2,8-sialyltransferase 8B,Mouse,Mus musculus,Polysialic acid synthase,Sialyltransferase 8B,Sialyltransferase X,Sialytransferase St8Sia II,Siat8b,SIAT8-B,St8sia2,ST8SiaII,STX,Stx
EIAAB38415 Alpha-2,8-sialyltransferase 8F,Mouse,Mus musculus,Sialyltransferase 8F,Sialytransferase St8Sia VI,Siat8f,SIAT8-F,St8sia6,ST8SiaVI
EIAAB38413 Alpha-2,8-sialyltransferase 8E,Homo sapiens,Human,Sialyltransferase 8E,Sialytransferase St8Sia V,SIAT8E,SIAT8-E,ST8SIA5,ST8SiaV
EIAAB38416 Alpha-2,8-sialyltransferase 8F,Homo sapiens,Human,Sialyltransferase 8F,Sialytransferase St8Sia VI,SIAT8F,SIAT8-F,ST8SIA6,ST8SiaVI
EIAAB38414 Alpha-2,8-sialyltransferase 8E,Mouse,Mus musculus,Sialyltransferase 8E,Sialytransferase St8Sia V,Siat8e,SIAT8-E,St8sia5,ST8SiaV,St8siav
EIAAB38430 Alpha 2,6-ST 1,B-cell antigen CD75,Beta-galactoside alpha-2,6-sialyltransferase 1,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1,Homo sapiens,Human,Sialyltransferase 1,SIAT1,
EIAAB38431 Alpha 2,6-ST 2,Beta-galactoside alpha-2,6-sialyltransferase 2,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2,Homo sapiens,hST6Gal II,Human,KIAA1877,Sialyltransferase 2,SIAT2,
EIAAB38433 Alpha 2,6-ST 2,Beta-galactoside alpha-2,6-sialyltransferase 2,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2,Kiaa1877,Mouse,Mus musculus,Sialyltransferase 2,ST6Gal II,St6gal2
EIAAB38432 Alpha 2,6-ST 2,Beta-galactoside alpha-2,6-sialyltransferase 2,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2,Rat,Rattus norvegicus,Sialyltransferase 2,ST6Gal II,St6gal2,ST6Ga
EIAAB38435 Alpha 2,6-ST 2,Beta-galactoside alpha-2,6-sialyltransferase 2,Bos taurus,Bovine,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2,Sialyltransferase 2,ST6Gal II,ST6GAL2,ST6GalII
EIAAB38429 Alpha 2,6-ST 1,Beta-galactoside alpha-2,6-sialyltransferase 1,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1,Mouse,Mus musculus,Sialyltransferase 1,Siat1,ST6Gal I,St6gal1,ST6
EIAAB38427 Alpha 2,6-ST 1,Beta-galactoside alpha-2,6-sialyltransferase 1,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1,Rat,Rattus norvegicus,Sialyltransferase 1,Siat1,ST6Gal I,St6gal1,
EIAAB38402 Alpha-2,8-sialyltransferase 8A,Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase,Ganglioside GD3 synthase,Ganglioside GT3 synthase,Homo sapiens,Human,Sialyltransferase 8A,Sialytransferase St8Sia I
EIAAB38390 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2,Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase,GalNAc alpha-2,6-sialyltransferase II,Mouse,Mus musculus,Sialyltransferase 7B,Siat7,Siat7b,S
EIAAB38428 Alpha 2,6-ST 1,Beta-galactoside alpha-2,6-sialyltransferase 1,Chicken,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1,Gallus gallus,Sialyltransferase 1,SIAT1,ST6Gal I,ST6GAL1,
EIAAB38434 Alpha 2,6-ST 2,Beta-galactoside alpha-2,6-sialyltransferase 2,Chicken,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2,Gallus gallus,Sialyltransferase 2,ST6Gal II,ST6GAL2,ST6Ga
EIAAB38398 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5,GalNAc alpha-2,6-sialyltransferase V,GD1 alpha synthase,Homo sapiens,Human,Sialyltransferase 7E,SIAT7E,SIAT7-E,ST6GalNAc V,ST6GALNAC5,ST6Gal
EIAAB38379 Alpha 2,3-ST 1,Beta-galactoside alpha-2,3-sialyltransferase 1,Chicken,CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1,Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase,Gallus ga


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur