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CMRF35-like molecule (CLM) (Dendritic cell-derived Ig-like receptor 1) (DIgR1) (Immunoglobulin superfamily member 7) (IgSF7) (Leukocyte mono-Ig-like receptor 2) (Myeloid-associated immunoglobulin-like receptor 2) (MAIR-2) (MAIR-II)

 CLM_MOUSE               Reviewed;         230 AA.
Q7TSN2; Q7TN55; Q8JZM5;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
23-MAY-2018, entry version 99.
RecName: Full=CMRF35-like molecule;
Short=CLM;
AltName: Full=Dendritic cell-derived Ig-like receptor 1;
Short=DIgR1;
AltName: Full=Immunoglobulin superfamily member 7;
Short=IgSF7;
AltName: Full=Leukocyte mono-Ig-like receptor 2;
AltName: Full=Myeloid-associated immunoglobulin-like receptor 2;
Short=MAIR-2;
Short=MAIR-II;
Flags: Precursor;
Name=Clm; Synonyms=Cd300c, Igsf7, Lmir2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND
SUBCELLULAR LOCATION.
TISSUE=Dendritic cell;
PubMed=11549249; DOI=10.1006/bbrc.2001.5539;
Luo K., Zhang W., Sui L., Li N., Zhang M., Ma X., Zhang L., Cao X.;
"DIgR1, a novel membrane receptor of the immunoglobulin gene
superfamily, is preferentially expressed by antigen-presenting
cells.";
Biochem. Biophys. Res. Commun. 287:35-41(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY,
SUBCELLULAR LOCATION, AND INTERACTION WITH TYROBP; HCST AND FCR GAMMA.
STRAIN=CBA/J; TISSUE=Mast cell;
PubMed=12893283; DOI=10.1016/S0006-291X(03)01245-2;
Kumagai H., Oki T., Tamitsu K., Feng S.-Z., Ono M., Nakajima H.,
Bao Y.-C., Kawakami Y., Nagayoshi K., Copeland N.G., Gilbert D.J.,
Jenkins N.A., Kawakami T., Kitamura T.;
"Identification and characterization of a new pair of immunoglobulin-
like receptors LMIR1 and 2 derived from murine bone marrow-derived
mast cells.";
Biochem. Biophys. Res. Commun. 307:719-729(2003).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE
SPECIFICITY, AND INTERACTION WITH TYROBP.
PubMed=12874256; DOI=10.1084/jem.20021825;
Yotsumoto K., Okoshi Y., Shibuya K., Yamazaki S., Tahara-Hanaoka S.,
Honda S., Osawa M., Kuroiwa A., Matsuda Y., Tenen D.G., Iwama A.,
Nakauchi H., Shibuya A.;
"Paired activating and inhibitory immunoglobulin-like receptors, MAIR-
I and MAIR-II, regulate mast cell and macrophage activation.";
J. Exp. Med. 198:223-233(2003).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
PubMed=14662855; DOI=10.4049/jimmunol.171.12.6541;
Chung D.-H., Humphrey M.B., Nakamura M.C., Ginzinger D.G.,
Seaman W.E., Daws M.R.;
"CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit
osteoclast formation.";
J. Immunol. 171:6541-6548(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N-3; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION, INTERACTION WITH TYROBP AND FCR GAMMA, AND MUTAGENESIS OF
LYS-197.
PubMed=17202337; DOI=10.4049/jimmunol.178.2.765;
Nakahashi C., Tahara-Hanaoka S., Totsuka N., Okoshi Y., Takai T.,
Ohkohchi N., Honda S., Shibuya K., Shibuya A.;
"Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-
bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages.";
J. Immunol. 178:765-770(2007).
-!- FUNCTION: Acts as an activating receptor in mast cells and
macrophages. {ECO:0000269|PubMed:12874256,
ECO:0000269|PubMed:12893283, ECO:0000269|PubMed:17202337}.
-!- SUBUNIT: Interacts with TYROBP, HCST and FcR gamma.
{ECO:0000269|PubMed:12874256, ECO:0000269|PubMed:12893283,
ECO:0000269|PubMed:17202337}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11549249,
ECO:0000269|PubMed:12893283}; Single-pass type I membrane protein
{ECO:0000269|PubMed:11549249, ECO:0000269|PubMed:12893283}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q7TSN2-1; Sequence=Displayed;
Name=2;
IsoId=Q7TSN2-2; Sequence=VSP_031607;
-!- TISSUE SPECIFICITY: Present on the surface of mast cells,
dendritic cells, peritoneal macrophages and a subset of B-cells
(at protein level). {ECO:0000269|PubMed:11549249,
ECO:0000269|PubMed:12874256, ECO:0000269|PubMed:12893283}.
-!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB098476; BAC80269.1; -; mRNA.
EMBL; AB091767; BAC77076.1; -; mRNA.
EMBL; AB091768; BAC77077.1; -; mRNA.
EMBL; AY457050; AAR27941.1; -; mRNA.
EMBL; AL607025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC006801; AAH06801.1; -; mRNA.
CCDS; CCDS25616.1; -. [Q7TSN2-2]
PIR; JC7761; JC7761.
RefSeq; NP_598919.1; NM_134158.1. [Q7TSN2-2]
UniGene; Mm.2699; -.
ProteinModelPortal; Q7TSN2; -.
SMR; Q7TSN2; -.
BioGrid; 228270; 3.
STRING; 10090.ENSMUSP00000090121; -.
PaxDb; Q7TSN2; -.
PRIDE; Q7TSN2; -.
Ensembl; ENSMUST00000092464; ENSMUSP00000090121; ENSMUSG00000044811. [Q7TSN2-2]
GeneID; 140497; -.
KEGG; mmu:140497; -.
UCSC; uc007mge.1; mouse. [Q7TSN2-2]
CTD; 140497; -.
MGI; MGI:2153249; AF251705.
eggNOG; ENOG410JCC5; Eukaryota.
eggNOG; ENOG4111BBB; LUCA.
GeneTree; ENSGT00470000042273; -.
HOGENOM; HOG000231065; -.
HOVERGEN; HBG063279; -.
InParanoid; Q7TSN2; -.
KO; K06719; -.
OMA; MTARAWA; -.
OrthoDB; EOG091G0RAD; -.
TreeFam; TF334441; -.
Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-MMU-6798695; Neutrophil degranulation.
PRO; PR:Q7TSN2; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000044811; -.
CleanEx; MM_AF251705; -.
CleanEx; MM_CD300C; -.
ExpressionAtlas; Q7TSN2; baseline and differential.
Genevisible; Q7TSN2; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
GO; GO:0050715; P:positive regulation of cytokine secretion; IDA:MGI.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain;
Membrane; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 230 CMRF35-like molecule.
/FTId=PRO_0000320127.
TOPO_DOM 25 189 Extracellular. {ECO:0000255}.
TRANSMEM 190 210 Helical. {ECO:0000255}.
TOPO_DOM 211 230 Cytoplasmic. {ECO:0000255}.
DOMAIN 25 126 Ig-like V-type.
SITE 197 197 Interaction with TYROBP or FcR gamma.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 43 110 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VAR_SEQ 139 140 Missing (in isoform 2).
{ECO:0000303|PubMed:11549249,
ECO:0000303|PubMed:12874256,
ECO:0000303|PubMed:12893283}.
/FTId=VSP_031607.
MUTAGEN 197 197 K->A: Abolishes interaction with TYROBP
or FcR gamma.
{ECO:0000269|PubMed:17202337}.
CONFLICT 34 34 A -> T (in Ref. 2; BAC80269).
{ECO:0000305}.
CONFLICT 37 37 E -> K (in Ref. 2; BAC80269).
{ECO:0000305}.
CONFLICT 176 176 A -> T (in Ref. 2; BAC80269).
{ECO:0000305}.
CONFLICT 191 191 W -> R (in Ref. 2; BAC80269).
{ECO:0000305}.
CONFLICT 216 216 R -> K (in Ref. 2; BAC80269).
{ECO:0000305}.
CONFLICT 223 224 SR -> TQ (in Ref. 2; BAC80269).
{ECO:0000305}.
SEQUENCE 230 AA; 25402 MW; 28992E9A0D5DAE3C CRC64;
MIPRVIRLWL PSALFLSQVP GCVPLHGPST ITGAVGESLS VSCQYEEKFK TKDKFWCRGS
LKVLCKDIVK TSSSEEVRNG RVTIRDHPDN LTFTVTYESL TLEDADTYMC AVDISLFDGS
LGFDKYFKIE LSVVPSEDPV PVTGSSLESG RDILESPTSS VGHTHPSVTT DDTIPAPCPQ
PRSLRSSLYF WVLVSLKLFL FLSMLGAVLW VNRPQRCSGG SSSRPCYENQ


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