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COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3)

 COT1_MOUSE              Reviewed;         422 AA.
Q60632; Q61438;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 2.
12-SEP-2018, entry version 149.
RecName: Full=COUP transcription factor 1;
Short=COUP-TF1;
AltName: Full=COUP transcription factor I;
Short=COUP-TF I;
AltName: Full=Nuclear receptor subfamily 2 group F member 1;
AltName: Full=V-erbA-related protein 3;
Short=EAR-3;
Name=Nr2f1; Synonyms=Erbal3, Tfcoup1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ;
PubMed=8183930; DOI=10.1073/pnas.91.10.4451;
Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.;
"Spatiotemporal expression patterns of chicken ovalbumin upstream
promoter-transcription factors in the developing mouse central nervous
system: evidence for a role in segmental patterning of the
diencephalon.";
Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7947324; DOI=10.1016/0925-4773(94)90098-1;
Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S.,
Vervaart J.M.A., Schoorlemmer J., Kruijer W.;
"Cloning and expression during development of three murine members of
the COUP family of nuclear orphan receptors.";
Mech. Dev. 47:81-97(1994).
-!- FUNCTION: Coup (chicken ovalbumin upstream promoter) transcription
factor binds to the ovalbumin promoter and, in conjunction with
another protein (S300-II) stimulates initiation of transcription.
Binds to both direct repeats and palindromes of the 5'-AGGTCA-3'
motif. Represses transcriptional activity of LHCG (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Binds DNA as dimer; homodimer and probable heterodimer
with NR2F6. Interacts with GTF2B; this interaction is direct.
Interacts with COPS2. {ECO:0000250|UniProtKB:P10589}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DEVELOPMENTAL STAGE: Expression begins in 8.5-day-old embryos,
peaks at 14-15 days and declines before birth.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
subfamily. {ECO:0000305}.
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EMBL; U07625; AAA19853.1; -; mRNA.
EMBL; X74134; CAA52231.1; -; mRNA.
PIR; I48305; I48305.
RefSeq; NP_034281.2; NM_010151.3.
UniGene; Mm.439653; -.
ProteinModelPortal; Q60632; -.
SMR; Q60632; -.
BioGrid; 199495; 1.
STRING; 10090.ENSMUSP00000089036; -.
iPTMnet; Q60632; -.
PhosphoSitePlus; Q60632; -.
MaxQB; Q60632; -.
PaxDb; Q60632; -.
PeptideAtlas; Q60632; -.
PRIDE; Q60632; -.
GeneID; 13865; -.
KEGG; mmu:13865; -.
CTD; 7025; -.
MGI; MGI:1352451; Nr2f1.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
HOGENOM; HOG000260820; -.
HOVERGEN; HBG005606; -.
InParanoid; Q60632; -.
KO; K08547; -.
PhylomeDB; Q60632; -.
ChiTaRS; Nr2f1; mouse.
PRO; PR:Q60632; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_NR2F1; -.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
GO; GO:0044323; F:retinoic acid-responsive element binding; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0021796; P:cerebral cortex regionalization; IMP:MGI.
GO; GO:0030900; P:forebrain development; IDA:MGI.
GO; GO:0010977; P:negative regulation of neuron projection development; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0007399; P:nervous system development; ISO:MGI.
GO; GO:0001764; P:neuron migration; IDA:MGI.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003068; COUP_TF.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01282; COUPTNFACTOR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
Receptor; Reference proteome; Repressor; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 422 COUP transcription factor 1.
/FTId=PRO_0000053603.
DOMAIN 183 409 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 82 157 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 85 105 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 121 145 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 343 422 Important for dimerization.
COMPBIAS 32 38 Poly-Gly.
CONFLICT 36 37 Missing (in Ref. 2; AAA19853).
{ECO:0000305}.
CONFLICT 66 66 Q -> A (in Ref. 2; AAA19853).
{ECO:0000305}.
SEQUENCE 422 AA; 46085 MW; C16591638E1E2500 CRC64;
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT PQTPGQPGAP
ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK RSVRRNLTYT
CRANRNCPID QHHRNQCQYC RLKKCLKVGM RREAVQRGRM PPTQPNPGQY ALTNGDPLNG
HCYLSGYISL LLRAEPYPTS RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP
DLQITDQVSL LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI
FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA LEEYVRSQYP
NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS SFNWPYMSIQ
CS


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