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COUP transcription factor 2 (COUP-TF2) (Apolipoprotein AI regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)

 COT2_MOUSE              Reviewed;         414 AA.
P43135;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
13-APR-2004, sequence version 2.
25-OCT-2017, entry version 152.
RecName: Full=COUP transcription factor 2;
Short=COUP-TF2;
AltName: Full=Apolipoprotein AI regulatory protein 1;
Short=ARP-1;
AltName: Full=COUP transcription factor II;
Short=COUP-TF II;
AltName: Full=Nuclear receptor subfamily 2 group F member 2;
Name=Nr2f2; Synonyms=Aporp1, Arp-1, Arp1, Tfcoup2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7947324; DOI=10.1016/0925-4773(94)90098-1;
Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S.,
Vervaart J.M.A., Schoorlemmer J., Kruijer W.;
"Cloning and expression during development of three murine members of
the COUP family of nuclear orphan receptors.";
Mech. Dev. 47:81-97(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ;
PubMed=8183930; DOI=10.1073/pnas.91.10.4451;
Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.;
"Spatiotemporal expression patterns of chicken ovalbumin upstream
promoter-transcription factors in the developing mouse central nervous
system: evidence for a role in segmental patterning of the
diencephalon.";
Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH ZFPM2, AND MUTAGENESIS OF 363-LEU--LEU-367.
PubMed=11382775; DOI=10.1074/jbc.M103577200;
Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.;
"Friend of GATA 2 physically interacts with chicken ovalbumin upstream
promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent
activation of the atrial natriuretic factor promoter.";
J. Biol. Chem. 276:28029-28036(2001).
-!- FUNCTION: Ligand-activated transcription factor. Activated by high
concentrations of 9-cis-retinoic acid and all-trans-retinoic acid,
but not by dexamethasone, cortisol or progesterone (in vitro).
Regulation of the apolipoprotein A-I gene transcription. Binds to
DNA site A (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with SQSTM1. Binds DNA as a dimer; homodimer or
heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and
PPARGC1A (By similarity). Interacts with ZFPM2. {ECO:0000250,
ECO:0000269|PubMed:11382775}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
subfamily. {ECO:0000305}.
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EMBL; X76653; CAA54096.1; -; mRNA.
EMBL; U07635; AAA19854.1; -; mRNA.
EMBL; BC042484; AAH42484.1; -; mRNA.
CCDS; CCDS21359.1; -.
RefSeq; NP_033827.2; NM_009697.3.
UniGene; Mm.158143; -.
ProteinModelPortal; P43135; -.
SMR; P43135; -.
BioGrid; 198166; 1.
STRING; 10090.ENSMUSP00000032768; -.
iPTMnet; P43135; -.
PhosphoSitePlus; P43135; -.
PaxDb; P43135; -.
PeptideAtlas; P43135; -.
PRIDE; P43135; -.
Ensembl; ENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551.
GeneID; 11819; -.
KEGG; mmu:11819; -.
UCSC; uc009hni.1; mouse.
CTD; 7026; -.
MGI; MGI:1352452; Nr2f2.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00760000118948; -.
HOGENOM; HOG000260820; -.
HOVERGEN; HBG005606; -.
InParanoid; P43135; -.
KO; K08548; -.
OMA; GNQGTQP; -.
OrthoDB; EOG091G0YX6; -.
PhylomeDB; P43135; -.
TreeFam; TF352097; -.
PRO; PR:P43135; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000030551; -.
CleanEx; MM_NR2F2; -.
ExpressionAtlas; P43135; baseline and differential.
Genevisible; P43135; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0001972; F:retinoic acid binding; ISS:UniProtKB.
GO; GO:0004879; F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISO:MGI.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
GO; GO:0009566; P:fertilization; IMP:MGI.
GO; GO:0030900; P:forebrain development; IDA:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0060173; P:limb development; IMP:MGI.
GO; GO:0001945; P:lymph vessel development; IEP:BHF-UCL.
GO; GO:0001893; P:maternal placenta development; IMP:MGI.
GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:MGI.
GO; GO:0010596; P:negative regulation of endothelial cell migration; ISO:MGI.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0001764; P:neuron migration; IDA:MGI.
GO; GO:0060674; P:placenta blood vessel development; IMP:MGI.
GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0009956; P:radial pattern formation; IMP:MGI.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0060849; P:regulation of transcription involved in lymphatic endothelial cell fate commitment; ISO:MGI.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003068; COUP_TF.
InterPro; IPR035500; NHR_like_domain.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01282; COUPTNFACTOR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
Phosphoprotein; Receptor; Reference proteome; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 414 COUP transcription factor 2.
/FTId=PRO_0000053607.
DNA_BIND 76 151 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 79 99 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 115 139 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 117 414 Interaction with ZFPM2.
{ECO:0000269|PubMed:11382775}.
REGION 183 414 Ligand-binding. {ECO:0000250}.
REGION 337 414 Important for dimerization.
COMPBIAS 71 75 Poly-Gln.
MOD_RES 51 51 Phosphothreonine.
{ECO:0000250|UniProtKB:P24468}.
MUTAGEN 363 367 LLLRL->RSLRF: Abolishes interaction with
ZFPM2. {ECO:0000269|PubMed:11382775}.
CONFLICT 36 36 A -> P (in Ref. 1; CAA54096).
{ECO:0000305}.
SEQUENCE 414 AA; 45571 MW; C24CB2E8C8A27E8C CRC64;
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ
GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN
CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG
YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD
QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF
GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ


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