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CRISPR-associated endoribonuclease Cas2 (EC 3.1.-.-)

 CAS2_STRTR              Reviewed;         114 AA.
G3ECR3;
13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
16-NOV-2011, sequence version 1.
20-JUN-2018, entry version 24.
RecName: Full=CRISPR-associated endoribonuclease Cas2;
EC=3.1.-.-;
Name=cas2;
Streptococcus thermophilus.
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Streptococcus.
NCBI_TaxID=1308;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN PLASMID RESISTANCE,
EXPRESSION OF CRISPR3/CAS IN E.COLI, AND DISRUPTION PHENOTYPE.
STRAIN=DGCC7710;
PubMed=21813460; DOI=10.1093/nar/gkr606;
Sapranauskas R., Gasiunas G., Fremaux C., Barrangou R., Horvath P.,
Siksnys V.;
"The Streptococcus thermophilus CRISPR/Cas system provides immunity in
Escherichia coli.";
Nucleic Acids Res. 39:9275-9282(2011).
-!- FUNCTION: CRISPR (clustered regularly interspaced short
palindromic repeat), is an adaptive immune system that provides
protection against mobile genetic elements (viruses, transposable
elements and conjugative plasmids). CRISPR clusters contain
spacers, sequences complementary to antecedent mobile elements,
and target invading nucleic acids. CRISPR clusters are transcribed
and processed into CRISPR RNA (crRNA) (Probable). Functions as a
ssRNA-specific endoribonuclease. Involved in the integration of
spacer DNA into the CRISPR cassette (By similarity). {ECO:0000250,
ECO:0000305}.
-!- FUNCTION: When the CRISPR3/cas system consisting of cas9-cas1-
cas2-csn2-CRISPR3 or just cas9-CRISPR3 is expressed in E.coli it
prevents plasmids homologous to spacers 1 or 2 from transforming.
{ECO:0000269|PubMed:21813460}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- SUBUNIT: Homodimer, forms a heterotetramer with a Cas1 homodimer.
{ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Plasmid transformation is still inhibited.
{ECO:0000269|PubMed:21813460}.
-!- SIMILARITY: Belongs to the CRISPR-associated endoribonuclease Cas2
protein family. {ECO:0000305}.
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EMBL; HQ712120; AEM62889.1; -; Genomic_DNA.
RefSeq; WP_023909843.1; NZ_PHHK01000011.1.
SMR; G3ECR3; -.
GO; GO:0004521; F:endoribonuclease activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:InterPro.
HAMAP; MF_01471; Cas2; 1.
InterPro; IPR021127; CRISPR_associated_Cas2.
InterPro; IPR019199; Virulence_VapD/CRISPR_Cas2.
Pfam; PF09827; CRISPR_Cas2; 1.
TIGRFAMs; TIGR01573; cas2; 1.
1: Evidence at protein level;
Antiviral defense; Endonuclease; Hydrolase; Magnesium; Metal-binding;
Nuclease.
CHAIN 1 114 CRISPR-associated endoribonuclease Cas2.
/FTId=PRO_0000417731.
METAL 13 13 Magnesium; catalytic. {ECO:0000255}.
SEQUENCE 114 AA; 13413 MW; B4B7677D88CEA6D6 CRC64;
MSYRYMRMIL MFDMPTDTAE ERKAYRKFRK FLLSEGFIMH QFSVYSKLLL NHTANTAMVG
RLKANNPKKG NITILTVTEK QFARMIYLYG DKNTSIANSE ERLVFLGDNY CDED


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