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CST complex subunit STN1 (Suppressor of cdc thirteen homolog) (AtSTN1)

 STN1_ARATH              Reviewed;         160 AA.
Q9LMK5;
23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
23-MAY-2018, entry version 103.
RecName: Full=CST complex subunit STN1 {ECO:0000303|PubMed:19064932};
AltName: Full=Suppressor of cdc thirteen homolog {ECO:0000303|PubMed:19064932};
Short=AtSTN1 {ECO:0000303|PubMed:19064932};
Name=STN1 {ECO:0000303|PubMed:19064932};
OrderedLocusNames=At1g07130 {ECO:0000312|Araport:AT1G07130};
ORFNames=F10K1.17 {ECO:0000312|EMBL:AAF82208.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=19064932; DOI=10.1073/pnas.0807867105;
Song X., Leehy K., Warrington R.T., Lamb J.C., Surovtseva Y.V.,
Shippen D.E.;
"STN1 protects chromosome ends in Arabidopsis thaliana.";
Proc. Natl. Acad. Sci. U.S.A. 105:19815-19820(2008).
[7]
INTERACTION WITH CTC1.
PubMed=19854131; DOI=10.1016/j.molcel.2009.09.017;
Surovtseva Y.V., Churikov D., Boltz K.A., Song X., Lamb J.C.,
Warrington R., Leehy K., Heacock M., Price C.M., Shippen D.E.;
"Conserved telomere maintenance component 1 interacts with STN1 and
maintains chromosome ends in higher eukaryotes.";
Mol. Cell 36:207-218(2009).
[8]
INTERACTION WITH TEN1.
PubMed=23572541; DOI=10.1105/tpc.112.107425;
Leehy K.A., Lee J.R., Song X., Renfrew K.B., Shippen D.E.;
"MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein
that modulates telomerase processivity in Arabidopsis.";
Plant Cell 25:1343-1354(2013).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=25299252; DOI=10.1371/journal.pgen.1004682;
Derboven E., Ekker H., Kusenda B., Bulankova P., Riha K.;
"Role of STN1 and DNA polymerase alpha in telomere stability and
genome-wide replication in Arabidopsis.";
PLoS Genet. 10:E1004682-E1004682(2014).
[10]
FUNCTION, AND INTERACTION WITH TEN1 AND POT1A.
PubMed=25329641; DOI=10.1371/journal.pgen.1004738;
Renfrew K.B., Song X., Lee J.R., Arora A., Shippen D.E.;
"POT1a and components of CST engage telomerase and regulate its
activity in Arabidopsis.";
PLoS Genet. 10:E1004738-E1004738(2014).
-!- FUNCTION: Component of the CST complex, a complex that binds to
single-stranded DNA and is required to protect telomeres from DNA
degradation. The CST complex binds single-stranded DNA with high
affinity in a sequence-independent manner, while isolated subunits
bind DNA with low affinity by themselves (PubMed:19064932).
Associates with enzymatically active telomerase (PubMed:25329641).
Plays a genomewide role in DNA replication and facilitates re-
replication at non-telomeric loci (PubMed:25299252).
{ECO:0000269|PubMed:19064932, ECO:0000269|PubMed:25299252,
ECO:0000269|PubMed:25329641}.
-!- SUBUNIT: Component of the CST complex, composed of CTC1, TEN1 and
STN1. Interacts with CTC1 (PubMed:19854131). Interacts with TEN1
(PubMed:23572541, PubMed:25329641). Interacts with POT1A
(PubMed:25329641). In vitro interaction with TEN1 and POT1A is
mutually exclusive, indicating that POT1A and TEN1 may compete for
the same binding site (PubMed:25329641).
{ECO:0000269|PubMed:19854131, ECO:0000269|PubMed:23572541,
ECO:0000269|PubMed:25329641}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19064932}.
Chromosome, telomere {ECO:0000269|PubMed:19064932}.
-!- TISSUE SPECIFICITY: Widely expressed.
{ECO:0000269|PubMed:19064932}.
-!- DISRUPTION PHENOTYPE: Plants display an immediate onset of growth
and developmental defects and reduced fertility, probably due to
impaired telomeres (PubMed:19064932). In nearly all mutants,
apical dominance is completely abolished, leading to multiple
inflorescence bolts that are often fused (PubMed:19064932). In
addition, floral phyllotaxy is perturbed and siliques develop at
irregular positions on the inflorescence bolt (PubMed:19064932).
Moreover, leaf size is substantially reduced, likely reflecting
defects in cell proliferation (PubMed:19064932). These effects are
accompanied by catastrophic loss of telomeric and subtelomeric
DNA, high levels of end-to-end chromosome fusions, increased G-
overhang signals, and elevated telomere recombination
(PubMed:19064932). Progressive loss of telomeric DNA and gradual
onset of telomere dysfunction (PubMed:25299252). Hindered re-
replication of heterochromatic regions (PubMed:25299252).
{ECO:0000269|PubMed:19064932, ECO:0000269|PubMed:25299252}.
-!- SIMILARITY: Belongs to the STN1 family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AC067971; AAF82208.1; -; Genomic_DNA.
EMBL; CP002684; AEE28079.1; -; Genomic_DNA.
EMBL; AK118772; BAC43365.1; -; mRNA.
EMBL; BT005022; AAO50555.1; -; mRNA.
EMBL; AY086427; AAM63429.1; -; mRNA.
PIR; B86206; B86206.
RefSeq; NP_563781.1; NM_100586.2.
UniGene; At.27320; -.
UniGene; At.74093; -.
ProteinModelPortal; Q9LMK5; -.
SMR; Q9LMK5; -.
BioGrid; 22464; 3.
STRING; 3702.AT1G07130.1; -.
PaxDb; Q9LMK5; -.
PRIDE; Q9LMK5; -.
EnsemblPlants; AT1G07130.1; AT1G07130.1; AT1G07130.
GeneID; 837223; -.
Gramene; AT1G07130.1; AT1G07130.1; AT1G07130.
KEGG; ath:AT1G07130; -.
Araport; AT1G07130; -.
TAIR; locus:2007352; AT1G07130.
eggNOG; ENOG410IZIC; Eukaryota.
eggNOG; ENOG410XYJH; LUCA.
HOGENOM; HOG000090648; -.
InParanoid; Q9LMK5; -.
OMA; RLAKECY; -.
OrthoDB; EOG09360ULO; -.
PhylomeDB; Q9LMK5; -.
PRO; PR:Q9LMK5; -.
Proteomes; UP000006548; Chromosome 1.
ExpressionAtlas; Q9LMK5; differential.
Genevisible; Q9LMK5; AT.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IDA:TAIR.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0016233; P:telomere capping; IMP:TAIR.
InterPro; IPR012340; NA-bd_OB-fold.
InterPro; IPR004365; NA-bd_OB_tRNA.
Pfam; PF01336; tRNA_anti-codon; 1.
SUPFAM; SSF50249; SSF50249; 1.
1: Evidence at protein level;
Chromosome; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Telomere.
CHAIN 1 160 CST complex subunit STN1.
/FTId=PRO_0000392992.
DNA_BIND 41 133 OB.
SEQUENCE 160 AA; 17598 MW; C8B66C406262B72E CRC64;
MDRSLQSTHA KLVARDIQRL TQSPTESNSF SLLGGACVSR VEIVGTIVSR DLTPKFLKFG
VDDGTGCVTC VMWLNQLTSS YFSRWDPATI LLLASAARKQ AAQIRIGAVA RVRGRVGSYR
GVMQITANVA VAERDPNAEI LHWLECLKLG QSCYRVRIQS


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