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CUB and zona pellucida-like domain-containing protein 1 (CUB and ZP domain-containing protein 1) (Estrogen-regulated protein 1) (Uterus/ovary-specific protein 44)

 CUZD1_RAT               Reviewed;         607 AA.
Q9QZT0; O35360; Q5D000;
02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
02-MAY-2006, sequence version 2.
25-OCT-2017, entry version 96.
RecName: Full=CUB and zona pellucida-like domain-containing protein 1;
Short=CUB and ZP domain-containing protein 1;
AltName: Full=Estrogen-regulated protein 1;
AltName: Full=Uterus/ovary-specific protein 44;
Flags: Precursor;
Name=Cuzd1 {ECO:0000312|RGD:619771}; Synonyms=Erg1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1] {ECO:0000305, ECO:0000312|EMBL:AAD55939.1}
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
AND INDUCTION.
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAD55939.1};
TISSUE=Uterus {ECO:0000269|PubMed:10542259};
PubMed=10542259; DOI=10.1074/jbc.274.45.32215;
Chen D., Xu X., Zhu L.-J., Angervo M., Li Q., Bagchi M.K.,
Bagchi I.C.;
"Cloning and uterus/oviduct-specific expression of a novel estrogen-
regulated gene (ERG1).";
J. Biol. Chem. 274:32215-32224(1999).
[2] {ECO:0000305, ECO:0000312|EMBL:AAB71895.1}
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAB71895.1};
TISSUE=Uterus {ECO:0000312|EMBL:AAB71895.1};
PubMed=11416020; DOI=10.1210/endo.142.7.8247;
Huynh H., Ng C.Y., Lim K.B., Ong C.K., Ong C.S., Tran E.,
Nguyen T.T.T., Chan T.W.M.G.;
"Induction of UO-44 gene expression by tamoxifen in the rat uterus and
ovary.";
Endocrinology 142:2985-2995(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-607.
TISSUE=Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: CUZD1 antiserum inhibits cell attachment and
proliferation of ovarian cancer cells so may play a role in these
processes. May play a role in trypsin activation in pancreatic
acinar cells. May also play a role in the uterus during late
pregnancy (By similarity). {ECO:0000250|UniProtKB:P70412,
ECO:0000250|UniProtKB:Q86UP6}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
membrane {ECO:0000250}; Single-pass type I membrane protein
{ECO:0000250}. Note=Associated with zymogen granule membranes.
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed predominantly in epithelium of
uterus and oviduct. {ECO:0000269|PubMed:10542259,
ECO:0000269|PubMed:11416020}.
-!- DEVELOPMENTAL STAGE: In uterus, strongly expressed at proestrus,
declines at estrus and disappears at diestrus. In oviduct,
strongly expressed at both proestrus and estrus but declines
significantly at diestrus. In uterus, highly expressed on day 1 of
pregnancy but declines dramatically on day 2 and is not detected
between days 3 and 7. In oviduct, highly expressed on days 1 and 2
of pregnancy but declines significantly on days 3 and 4.
{ECO:0000269|PubMed:10542259}.
-!- INDUCTION: By estrogen, tamoxifen and growth hormone. Repressed by
progesterone and by the antiestrogen ICI 182780.
{ECO:0000269|PubMed:10542259, ECO:0000269|PubMed:11416020}.
-----------------------------------------------------------------------
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EMBL; AF167170; AAD55939.1; -; mRNA.
EMBL; AF022147; AAB71895.1; -; mRNA.
EMBL; BC090345; AAH90345.1; -; mRNA.
RefSeq; NP_446457.1; NM_054005.1.
UniGene; Rn.10825; -.
ProteinModelPortal; Q9QZT0; -.
SMR; Q9QZT0; -.
PhosphoSitePlus; Q9QZT0; -.
PaxDb; Q9QZT0; -.
PRIDE; Q9QZT0; -.
GeneID; 117179; -.
KEGG; rno:117179; -.
UCSC; RGD:619771; rat.
CTD; 50624; -.
RGD; 619771; Cuzd1.
eggNOG; ENOG410IHBC; Eukaryota.
eggNOG; ENOG410XQVR; LUCA.
HOGENOM; HOG000060083; -.
HOVERGEN; HBG081378; -.
InParanoid; Q9QZT0; -.
PhylomeDB; Q9QZT0; -.
PRO; PR:Q9QZT0; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016021; C:integral component of membrane; IDA:RGD.
GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0042589; C:zymogen granule membrane; ISS:UniProtKB.
GO; GO:0007565; P:female pregnancy; TAS:RGD.
GO; GO:0009755; P:hormone-mediated signaling pathway; IDA:RGD.
GO; GO:0032023; P:trypsinogen activation; ISS:UniProtKB.
CDD; cd00041; CUB; 2.
Gene3D; 2.60.120.290; -; 2.
InterPro; IPR000859; CUB_dom.
InterPro; IPR029834; Cuzd1.
InterPro; IPR035914; sperma_CUB_dom.
InterPro; IPR001507; ZP_dom.
PANTHER; PTHR44510:SF1; PTHR44510:SF1; 1.
Pfam; PF00431; CUB; 2.
Pfam; PF00100; Zona_pellucida; 1.
PRINTS; PR00023; ZPELLUCIDA.
SMART; SM00042; CUB; 2.
SMART; SM00241; ZP; 1.
SUPFAM; SSF49854; SSF49854; 2.
PROSITE; PS01180; CUB; 2.
PROSITE; PS51034; ZP_2; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasmic vesicle; Disulfide bond; Glycoprotein;
Membrane; Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 607 CUB and zona pellucida-like domain-
containing protein 1. {ECO:0000255}.
/FTId=PRO_0000233333.
TOPO_DOM 20 568 Extracellular. {ECO:0000255}.
TRANSMEM 569 589 Helical. {ECO:0000255}.
TOPO_DOM 590 607 Cytoplasmic. {ECO:0000255}.
DOMAIN 32 146 CUB 1. {ECO:0000255|PROSITE-
ProRule:PRU00059}.
DOMAIN 154 265 CUB 2. {ECO:0000255|PROSITE-
ProRule:PRU00059}.
DOMAIN 276 519 ZP. {ECO:0000255|PROSITE-
ProRule:PRU00375}.
CARBOHYD 22 22 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 67 67 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 195 195 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 419 419 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 32 58 {ECO:0000255|PROSITE-ProRule:PRU00059}.
DISULFID 85 107 {ECO:0000255|PROSITE-ProRule:PRU00059}.
DISULFID 154 180 {ECO:0000255|PROSITE-ProRule:PRU00059}.
DISULFID 207 229 {ECO:0000255|PROSITE-ProRule:PRU00059}.
DISULFID 442 498 {ECO:0000255|PROSITE-ProRule:PRU00059}.
CONFLICT 35 35 S -> M (in Ref. 1; AAD55939).
{ECO:0000305}.
CONFLICT 273 273 H -> T (in Ref. 3; AAH90345).
{ECO:0000305}.
CONFLICT 469 469 E -> K (in Ref. 3; AAH90345).
{ECO:0000305}.
SEQUENCE 607 AA; 68640 MW; 68B59BCD31322012 CRC64;
MEVTGRLFIW AILAVSCRAQ LNSTAAEGRP RCTASLGGAN LGETHKALIL NLNADENCTW
TIERPENRSI RIIFSHIQLD PDSRCENESI KVFDGRSTSG PLLGEACSKN DFVPVFESSA
NSLTFQIVTD WTRVQRSVFI FYYFFSSGTT IPNCGGYLQT LEGSFSSPNY PRPHPELAYC
VWHIQVEKGY KINLNFTELF LEMDEYCRFD FIAVYDGPST TSGLLKQVCG RGTPTFESSS
DAMTVVLSTD YANSYRGFFA SYASTYVQEV NTHSLSCASD KMRVIISKSY LQSLNYHESN
LQLNDPTCRP SVSNVVEFSI PLHECGTIKK IEDHTISYTN IITFTQSPES AVITRKRHLQ
IVVTCEMEYN STVEILYITE DDVIQNQSVL GKYNTSMALY ESGSFENLIQ ESPYYVDLNQ
TLFVQATLHT SDPSLVVFLD TCRASPTSDF ASPTYDLISS GCSRDETCEV YPLFGHYGRF
QFNAFKFLRH LSSVYLKCKI LICDTSDHTS RCNQGCVSRR KRDIPSYKWK TDSVIGPIRL
KRDRLVNGDS GLLPQTHEAE ISKQPLSHLH LFSFMVLALN VVIVVTATVR HFLNRWKDHG
YQKLQVY


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