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Cadmium resistance transcriptional regulatory protein CadC (Cadmium efflux system accessory protein)

 CADC_LACLL              Reviewed;         119 AA.
P0A4U3; P94887;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
25-OCT-2017, entry version 62.
RecName: Full=Cadmium resistance transcriptional regulatory protein CadC;
AltName: Full=Cadmium efflux system accessory protein;
Name=cadC;
Lactococcus lactis subsp. lactis (Streptococcus lactis).
Plasmid pND302, and Plasmid pAH82.
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Lactococcus.
NCBI_TaxID=1360;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=M71; PLASMID=pND302;
PubMed=9339465; DOI=10.1006/plas.1997.1301;
Liu C.-Q., Khunajakr N., Chia L.G., Deng Y.-M., Charoenchai P.,
Dunn N.W.;
"Genetic analysis of regions involved in replication and cadmium
resistance of the plasmid pND302 from Lactococcus lactis.";
Plasmid 38:79-90(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DPC220; PLASMID=pAH82;
PubMed=10844674; DOI=10.1046/j.1365-2958.2000.01901.x;
O'Sullivan D., Twomey D.P., Coffey A., Hill C., Fitzgerald G.F.,
Ross P.R.;
"Novel type I restriction specificities through domain shuffling of
HsdS subunits in Lactococcus lactis.";
Mol. Microbiol. 36:866-875(2000).
-!- FUNCTION: Metal-binding repressor for the cad operon. Involved in
resistance to heavy metals, such as cadmium, bismuth, zinc or
lead. Metal binding causes the repressor to dissociate from the
DNA (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
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EMBL; U78967; AAB37344.1; -; Genomic_DNA.
EMBL; AF243383; AAF98301.1; -; Genomic_DNA.
RefSeq; NP_862601.1; NC_004966.1.
RefSeq; WP_003726380.1; NZ_LKLY01000055.1.
RefSeq; YP_001174713.1; NC_009435.1.
RefSeq; YP_001966470.1; NC_010901.1.
RefSeq; YP_004761536.1; NC_015863.1.
ProteinModelPortal; P0A4U3; -.
SMR; P0A4U3; -.
GeneID; 11013250; -.
GeneID; 3125820; -.
GeneID; 5077334; -.
GeneID; 6385740; -.
HOGENOM; HOG000144506; -.
GO; GO:0005622; C:intracellular; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00090; HTH_ARSR; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR011991; ArsR-like_HTH.
InterPro; IPR018334; ArsR_HTH.
InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF01022; HTH_5; 1.
PRINTS; PR00778; HTHARSR.
SMART; SM00418; HTH_ARSR; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00846; HTH_ARSR_1; 1.
PROSITE; PS50987; HTH_ARSR_2; 1.
3: Inferred from homology;
Cadmium; Cadmium resistance; DNA-binding; Metal-binding; Plasmid;
Transcription; Transcription regulation.
CHAIN 1 119 Cadmium resistance transcriptional
regulatory protein CadC.
/FTId=PRO_0000160617.
DOMAIN 23 118 HTH arsR-type. {ECO:0000255|PROSITE-
ProRule:PRU00340}.
DNA_BIND 58 77 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00340}.
METAL 6 6 Cadmium; shared with dimeric partner.
{ECO:0000255|PROSITE-ProRule:PRU00340}.
METAL 10 10 Cadmium; shared with dimeric partner.
{ECO:0000255|PROSITE-ProRule:PRU00340}.
METAL 57 57 Cadmium; shared with dimeric partner.
{ECO:0000255|PROSITE-ProRule:PRU00340}.
METAL 59 59 Cadmium; shared with dimeric partner.
{ECO:0000255|PROSITE-ProRule:PRU00340}.
SEQUENCE 119 AA; 13382 MW; B34C01C21DC2C944 CRC64;
MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL VHEDELCVCD
IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN IKILNLMELG VNFKEEVLA


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