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Calciseptin (Calciseptine) (CaS) (L-type calcium channel blocker)

 3SLS_DENPO              Reviewed;          60 AA.
P22947;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
22-NOV-2017, entry version 79.
RecName: Full=Calciseptin;
AltName: Full=Calciseptine;
Short=CaS;
AltName: Full=L-type calcium channel blocker;
Dendroaspis polylepis polylepis (Black mamba).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
NCBI_TaxID=8620;
[1]
PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
PubMed=1848702; DOI=10.1073/pnas.88.6.2437;
de Weille J.R., Schweitz H., Maes P., Tartar A., Lazdunski M.;
"Calciseptine, a peptide isolated from black mamba venom, is a
specific blocker of the L-type calcium channel.";
Proc. Natl. Acad. Sci. U.S.A. 88:2437-2440(1991).
[2]
SYNTHESIS.
PubMed=1450521;
Kuroda H., Chen Y.-N., Watanabe T.X., Kimura T., Sakakibara S.;
"Solution synthesis of calciseptine, an L-type specific calcium
channel blocker.";
Pept. Res. 5:265-268(1992).
[3]
SYNTHESIS OF 41-48.
PubMed=9636051; DOI=10.1021/bi9802723;
Kini R.M., Caldwell R.A., Wu Q.Y., Baumgarten C.M., Feher J.J.,
Evans H.J.;
"Flanking proline residues identify the L-type Ca2+ channel binding
site of calciseptine and FS2.";
Biochemistry 37:9058-9063(1998).
-!- FUNCTION: This specific blocker of the L-type calcium channel
(Cav1/CACNA1) is a smooth muscle relaxant and an inhibitor of
cardiac contractions. {ECO:0000269|PubMed:1848702}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1848702}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- MISCELLANEOUS: The sensitivity is higher in cells of the
cardiovascular system. Neuronal, and insulinoma cells L-type
calcium channel are more resistant. A total resistance is found in
skeletal muscle cells.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. L-type calcium blocker sub-subfamily.
{ECO:0000305}.
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PIR; A39165; A39165.
ProteinModelPortal; P22947; -.
SMR; P22947; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
InterPro; IPR018354; Snake_toxin_con_site.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Calcium channel impairing toxin; Cardiotoxin;
Direct protein sequencing; Disulfide bond;
Ion channel impairing toxin; Secreted; Toxin;
Voltage-gated calcium channel impairing toxin.
CHAIN 1 60 Calciseptin.
/FTId=PRO_0000093667.
REGION 41 48 Important for binding to L-type calcium
channels. {ECO:0000269|PubMed:9636051}.
DISULFID 3 22 {ECO:0000250}.
DISULFID 17 39 {ECO:0000250}.
DISULFID 41 52 {ECO:0000250}.
DISULFID 53 58 {ECO:0000250}.
SEQUENCE 60 AA; 7044 MW; 2F14B05972A40FFF CRC64;
RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT ECCKGDRCNK


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