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Calcitonin

 CALC_CHICK              Reviewed;         138 AA.
P07660;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 2.
10-MAY-2017, entry version 105.
RecName: Full=Calcitonin;
Flags: Precursor;
Name=CALCA; Synonyms=CALC;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3666142; DOI=10.1016/0014-5793(87)80510-0;
Minvielle S., Cressent M., Delehaye M.C., Segond N., Milhaud G.,
Jullienne A., Moukhtar M.S., Lasmoles F.;
"Sequence and expression of the chicken calcitonin gene.";
FEBS Lett. 223:63-68(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 12-138.
PubMed=4054101;
Lasmoles F., Jullienne A., Day F., Minvielle S., Milhaud G.,
Moukhtar M.S.;
"Elucidation of the nucleotide sequence of chicken calcitonin mRNA:
direct evidence for the expression of a lower vertebrate calcitonin-
like gene in man and rat.";
EMBO J. 4:2603-2607(1985).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 71-117.
PubMed=3838160; DOI=10.1016/0014-5793(85)80242-8;
Lasmoles F., Jullienne A., Desplan C., Milhaud G., Moukhtar M.S.;
"Structure of chicken calcitonin predicted by partial nucleotide
sequence of its precursor.";
FEBS Lett. 180:113-116(1985).
[4]
NUCLEOTIDE SEQUENCE OF 82-113.
PubMed=3782060; DOI=10.1093/oxfordjournals.jbchem.a121734;
Homma T., Watanabe M., Hirose S., Kanai A., Kangawa K., Matsuo H.;
"Isolation and determination of the amino acid sequence of chicken
calcitonin I from chicken ultimobranchial glands.";
J. Biochem. 100:459-467(1986).
-!- FUNCTION: Causes a rapid but short-lived drop in the level of
calcium and phosphate in blood by promoting the incorporation of
those ions in the bones.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin;
IsoId=P07660-1; Sequence=Displayed;
Name=Calcitonin-gene related peptide;
IsoId=P10286-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; X06311; CAA29630.1; -; Genomic_DNA.
EMBL; X06312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X06313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X03012; CAA26796.1; -; mRNA.
EMBL; M27563; AAA48648.1; -; mRNA.
PIR; S00153; TCCH.
UniGene; Gga.1232; -.
UniGene; Gga.4991; -.
ProteinModelPortal; P07660; -.
SMR; P07660; -.
STRING; 9031.ENSGALP00000038811; -.
PaxDb; P07660; -.
eggNOG; ENOG410IX7S; Eukaryota.
eggNOG; ENOG4111KS6; LUCA.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
InParanoid; P07660; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR021118; Calcitonin.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00270; CALCITONINA.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 79 {ECO:0000250}.
/FTId=PRO_0000004071.
PEPTIDE 82 113 Calcitonin. {ECO:0000269|PubMed:3782060}.
/FTId=PRO_0000004072.
PROPEP 118 138 {ECO:0000250}.
/FTId=PRO_0000004073.
MOD_RES 113 113 Proline amide. {ECO:0000250}.
DISULFID 82 88
CONFLICT 56 56 D -> E (in Ref. 2; CAA26796).
{ECO:0000305}.
SEQUENCE 138 AA; 15308 MW; 730B618CF724F248 CRC64;
MVMLKISSFL AVYALVVCQM DSFQAAPVRP GLESITDRVT LSDYEARRLL NALVKDFIQM
TAEELEQASE GNSLDRPISK RCASLSTCVL GKLSQELHKL QTYPRTDVGA GTPGKKRNVL
NDLDHERYAN YGETLGNN


Related products :

Catalog number Product name Quantity
orb80754 Salmon Calcitonin Acetate protein Calcitonin Acetate (Salmon) is synthetic polypeptide of 32 amino acids in the same linear sequencethat is found in clacitonin of salmon origin. Calcitonin Acetate (Sa 1 mg
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1107NF-V3035 Monoclonal Antibodies: Calcitonin; reactive species: Human; Clone: CT10; Isotype: IgG1, k; Specificity: Calcitonin 0.5ml
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SCH-1720-8502 SYNTHETIC SALMON CALCITONIN, Product Type Purified Protein, Specificity CALCITONIN, Target Species Fish, Host N_A, Format Purified, Isotypes , Applications E, Clone 0.5 mg
1720-8502 SYNTHETIC SALMON CALCITONIN, Product Type Purified Protein, Specificity CALCITONIN, Target Species Fish, Host N_A, Format Purified, Isotypes , Applications E, Clone 0.5 mg
orb60021 Salmon Calcitonin Salmon Calcitonin(Miacalcin, Fortical) is a synthetic polypeptide of 32 amino acids in the same linear sequence that is found in clacitonin of salmon origin. For research use only. 50 mg
014-11 Calcitonin [Asu1_7](Salmon)[Dicarba Analog of Salmon Calcitonin] _ 200ug 200 µg
SCH-MCA2122 MOUSE ANTI RAT CALCITONIN RECEPTOR, Product Type Monoclonal Antibody, Specificity CALCITONIN RECEPTOR, Target Species Rat, Host Mouse, Format Purified, Isotypes IgG1, Applications C, E, P*, WB, 0.1 mg
MCA2122 MOUSE ANTI RAT CALCITONIN RECEPTOR, Product Type Monoclonal Antibody, Specificity CALCITONIN RECEPTOR, Target Species Rat, Host Mouse, Format Purified, Isotypes IgG1, Applications C, E, P*, WB, 0.1 mg
20-272-190552 Calcitonin - Mouse monoclonal [13B9] to Calcitonin; Monoclonal 0.1 mg
56612-22-7 Calcitonin (human), trihydrochloride Calcitonin (human), trih 1g
20-272-190564 Calcitonin - Mouse monoclonal [24B2 ] to Calcitonin; Monoclonal 0.1 mg
20-272-191104 Calcitonin - Mouse monoclonal [13g11] to Calcitonin; Monoclonal 0.1 mg
20-272-190563 Calcitonin - Mouse monoclonal [14A2 ] to Calcitonin; Monoclonal 0.1 mg
20-272-191103 Calcitonin - Mouse monoclonal [13f2] to Calcitonin; Monoclonal 0.1 mg
20-272-190560 Calcitonin - Mouse monoclonal [16B5 ] to Calcitonin; Monoclonal 0.1 mg
MCA2192 MOUSE ANTI RAT CALCITONIN RECEPTOR (C1b ISOFORM), Product Type Monoclonal Antibody, Specificity CALCITONIN RECEPTOR , Target Species Rat, Host Mouse, Format Purified, Isotypes IgG2a, Application 0.1 mg
SCH-MCA2122T MOUSE ANTI RAT CALCITONIN RECEPTOR, Product Type Monoclonal Antibody, Specificity CALCITONIN RECEPTOR, Target Species Rat, Host Mouse, Format Purified, Isotypes IgG1, Applications C, P*, Clone 10 µg
MCA2122T MOUSE ANTI RAT CALCITONIN RECEPTOR, Product Type Monoclonal Antibody, Specificity CALCITONIN RECEPTOR, Target Species Rat, Host Mouse, Format Purified, Isotypes IgG1, Applications C, P*, Clone 10 µg
SCH-MCA2192 MOUSE ANTI RAT CALCITONIN RECEPTOR (C1b ISOFORM), Product Type Monoclonal Antibody, Specificity CALCITONIN RECEPTOR , Target Species Rat, Host Mouse, Format Purified, Isotypes IgG2a, Application 0.1 mg
0100-0436 MOUSE ANTI HUMAN CALCITONIN, Product Type Monoclonal Antibody, Specificity CALCITONIN, Target Species Human, Host Mouse, Format Purified, Isotypes IgG1, Applications E, Clone Cn 44 (BGN_1199_4 0.2 mg
SCH-0100-0436 MOUSE ANTI HUMAN CALCITONIN, Product Type Monoclonal Antibody, Specificity CALCITONIN, Target Species Human, Host Mouse, Format Purified, Isotypes IgG1, Applications E, Clone Cn 44 (BGN_1199_4 0.2 mg
0100-0435 MOUSE ANTI HUMAN CALCITONIN, Product Type Monoclonal Antibody, Specificity CALCITONIN, Target Species Human, Host Mouse, Format Purified, Isotypes IgG2a, Applications E, Clone Cn11 (BGN_1199_1 0.2 mg
SCH-0100-0435 MOUSE ANTI HUMAN CALCITONIN, Product Type Monoclonal Antibody, Specificity CALCITONIN, Target Species Human, Host Mouse, Format Purified, Isotypes IgG2a, Applications E, Clone Cn11 (BGN_1199_1 0.2 mg


 

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