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Calcitonin
CALC_HORSE Reviewed; 140 AA.
Q9N0V5;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
31-JAN-2018, entry version 103.
RecName: Full=Calcitonin;
Flags: Precursor;
Name=CALCA; Synonyms=CALC;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thyroid;
PubMed=12581884; DOI=10.1016/S0303-7207(02)00289-7;
Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
"Molecular cloning and expression of equine calcitonin, calcitonin
gene-related peptide-I, and calcitonin gene-related peptide-II.";
Mol. Cell. Endocrinol. 199:119-128(2003).
-!- FUNCTION: Causes a rapid but short-lived drop in the level of
calcium and phosphate in blood by promoting the incorporation of
those ions in the bones. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin;
IsoId=Q9N0V5-1; Sequence=Displayed;
Name=Calcitonin-gene related peptide I;
IsoId=Q9N0T2-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; AF249307; AAF72526.1; -; mRNA.
RefSeq; NP_001075323.1; NM_001081854.3. [Q9N0V5-1]
RefSeq; XP_014596965.1; XM_014741479.1. [Q9N0V5-1]
UniGene; Eca.12754; -.
ProteinModelPortal; Q9N0V5; -.
SMR; Q9N0V5; -.
STRING; 9796.ENSECAP00000005990; -.
PaxDb; Q9N0V5; -.
Ensembl; ENSECAT00000008055; ENSECAP00000005990; ENSECAG00000007825. [Q9N0V5-1]
GeneID; 100033906; -.
KEGG; ecb:100033906; -.
CTD; 796; -.
eggNOG; ENOG410IX7S; Eukaryota.
eggNOG; ENOG4111KS6; LUCA.
GeneTree; ENSGT00390000010511; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
InParanoid; Q9N0V5; -.
KO; K12332; -.
OMA; RYANYGE; -.
OrthoDB; EOG091G0RF5; -.
TreeFam; TF333069; -.
Proteomes; UP000002281; Chromosome 7.
Bgee; ENSECAG00000007825; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR021118; Calcitonin.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00270; CALCITONINA.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 81 {ECO:0000250}.
/FTId=PRO_0000004044.
PEPTIDE 84 115 Calcitonin.
/FTId=PRO_0000004045.
PROPEP 120 140 {ECO:0000250}.
/FTId=PRO_0000004046.
MOD_RES 115 115 Proline amide. {ECO:0000250}.
DISULFID 84 90 {ECO:0000250}.
SEQUENCE 140 AA; 15358 MW; 8ACCC4015AF3DEB7 CRC64;
MGFWKFSPFL PLSILVLYQV GIIQAAPFRS ALESLPDPAV LPEEESRLLL AALVKDYVQM
KVRALEQEQE TGGASLDSPR AKRCSNLSTC VLGTYTQDLN KFHTFPQTAI GVGAPGKKRV
MARGLERDHG PHIGTSQDAY
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Pathways :
No related Items
Related Genes :
[CALCA CALC1] Calcitonin [Cleaved into: Calcitonin; Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)]
[CALCA CALC1] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[Calca Calc] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Crlr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[Calcrl Cgrpr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCR] Calcitonin receptor (CT-R)
[Calca Calc] Calcitonin
[Calca Calc] Calcitonin
[Calcr] Calcitonin receptor (CT-R)
[Calcr] Calcitonin receptor (CT-R) (C1A/C1B)
[RAMP1] Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
[CALCB CALC2] Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)
[RAMP2] Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)
[CRCP] DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)
[RAMP3] Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)
[CALCR] Calcitonin receptor (CT-R)
[CALCR] Calcitonin receptor (CT-R)
[] Calcitonin-1
[calcrla calcrl si:dkey-249o24.2 zgc:100872] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCA GW7_21359] Calcitonin (Calcitonin gene-related peptide 1 alpha-CGRP preproprotein)
[Crcp] DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP)
[Crcp] DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP)
[CALCA CALC CCALCI] Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)
[pdfr-1 seb-1 C13B9.4] Calcitonin receptor-like protein 1 (Pigment dispersing factor neuropeptide receptor homolog 1)
[CALCA CALC CCALCI] Calcitonin
[] Skin calcitonin gene-related peptide (S-CGRP)
Bibliography :
[29676776] Gene expression analysis of neuropeptides in oral mucosa during periodontal disease in nonhuman primates.
[29675278] Adrenocorticotropic Hormone Secreting Pheochromocytoma Underlying Glucocorticoid Induced Pheochromocytoma Crisis.
[29669679] Calcitonin Screening in Nodular Goiter-Upper Limits.
[29667896] A phase 1 study to assess the pharmacokinetics, safety, and tolerability of fremanezumab doses (225 mg, 675 mg and 900 mg) in Japanese and Caucasian healthy subjects.
[29662754] Magnesium-based implants: Beyond fixators.
[29664002] [Research of the heart protective effect of exercise precondition mediated by calcitonin gene related peptide on acute exhaustion rats].
[29663329] Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2.
[29661478] Chronic adriamycin treatment impairs CGRP-mediated functions of meningeal sensory nerves.
[29661063] Calcitonin Stewardship Strategies.
[29658374] Hypercalcemic crisis in third trimenon: evaluating the optimal treatment strategy.
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