GENTAUR Molecular Products.

 CALC_HORSE              Reviewed;         140 AA.
 Q9N0V5;
 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
 01-OCT-2000, sequence version 1.
 12-SEP-2018, entry version 105.
 RecName: Full=Calcitonin;
 Flags: Precursor;
 Name=CALCA; Synonyms=CALC;
 Equus caballus (Horse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
 NCBI_TaxID=9796;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA].
 TISSUE=Thyroid;
 PubMed=12581884; DOI=10.1016/S0303-7207(02)00289-7;
 Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
 "Molecular cloning and expression of equine calcitonin, calcitonin
 gene-related peptide-I, and calcitonin gene-related peptide-II.";
 Mol. Cell. Endocrinol. 199:119-128(2003).
 -!- FUNCTION: Causes a rapid but short-lived drop in the level of
     calcium and phosphate in blood by promoting the incorporation of
     those ions in the bones. {ECO:0000250}.
 -!- SUBCELLULAR LOCATION: Secreted.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=2;
     Name=Calcitonin;
       IsoId=Q9N0V5-1; Sequence=Displayed;
     Name=Calcitonin-gene related peptide I;
       IsoId=Q9N0T2-1; Sequence=External;
 -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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 EMBL; AF249307; AAF72526.1; -; mRNA.
 RefSeq; NP_001075323.1; NM_001081854.3. [Q9N0V5-1]
 RefSeq; XP_014596965.1; XM_014741479.1. [Q9N0V5-1]
 UniGene; Eca.12754; -.
 ProteinModelPortal; Q9N0V5; -.
 SMR; Q9N0V5; -.
 STRING; 9796.ENSECAP00000005990; -.
 PaxDb; Q9N0V5; -.
 PRIDE; Q9N0V5; -.
 Ensembl; ENSECAT00000008055; ENSECAP00000005990; ENSECAG00000007825. [Q9N0V5-1]
 GeneID; 100033906; -.
 KEGG; ecb:100033906; -.
 CTD; 796; -.
 eggNOG; ENOG410IX7S; Eukaryota.
 eggNOG; ENOG4111KS6; LUCA.
 GeneTree; ENSGT00390000010511; -.
 HOGENOM; HOG000038203; -.
 HOVERGEN; HBG031362; -.
 InParanoid; Q9N0V5; -.
 KO; K12332; -.
 OMA; RYANYGE; -.
 OrthoDB; EOG091G0RF5; -.
 TreeFam; TF333069; -.
 Proteomes; UP000002281; Chromosome 7.
 Bgee; ENSECAG00000007825; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
 GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
 InterPro; IPR021118; Calcitonin.
 InterPro; IPR021117; Calcitonin-like.
 InterPro; IPR021116; Calcitonin/adrenomedullin.
 InterPro; IPR018360; Calcitonin_CS.
 InterPro; IPR001693; Calcitonin_peptide-like.
 PANTHER; PTHR10505; PTHR10505; 1.
 Pfam; PF00214; Calc_CGRP_IAPP; 1.
 PRINTS; PR00270; CALCITONINA.
 SMART; SM00113; CALCITONIN; 1.
 PROSITE; PS00258; CALCITONIN; 1.
 2: Evidence at transcript level;
 Alternative splicing; Amidation; Cleavage on pair of basic residues;
 Complete proteome; Disulfide bond; Hormone; Reference proteome;
 Secreted; Signal.
 SIGNAL        1     25       {ECO:0000255}.
 PROPEP       26     81       {ECO:0000250}.
                              /FTId=PRO_0000004044.
 PEPTIDE      84    115       Calcitonin.
                              /FTId=PRO_0000004045.
 PROPEP      120    140       {ECO:0000250}.
                              /FTId=PRO_0000004046.
 MOD_RES     115    115       Proline amide. {ECO:0000250}.
 DISULFID     84     90       {ECO:0000250}.
 SEQUENCE   140 AA;  15358 MW;  8ACCC4015AF3DEB7 CRC64;
 MGFWKFSPFL PLSILVLYQV GIIQAAPFRS ALESLPDPAV LPEEESRLLL AALVKDYVQM
 KVRALEQEQE TGGASLDSPR AKRCSNLSTC VLGTYTQDLN KFHTFPQTAI GVGAPGKKRV
 MARGLERDHG PHIGTSQDAY

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