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Calcitonin gene-related peptide (CGRP)

 CALCA_CHICK             Reviewed;         125 AA.
P10286;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 2.
10-MAY-2017, entry version 94.
RecName: Full=Calcitonin gene-related peptide;
Short=CGRP;
Flags: Precursor;
Name=CALCA; Synonyms=CALC;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3666142; DOI=10.1016/0014-5793(87)80510-0;
Minvielle S., Cressent M., Delehaye M.C., Segond N., Milhaud G.,
Jullienne A., Moukhtar M.S., Lasmoles F.;
"Sequence and expression of the chicken calcitonin gene.";
FEBS Lett. 223:63-68(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 12-73.
PubMed=4054101;
Lasmoles F., Jullienne A., Day F., Minvielle S., Milhaud G.,
Moukhtar M.S.;
"Elucidation of the nucleotide sequence of chicken calcitonin mRNA:
direct evidence for the expression of a lower vertebrate calcitonin-
like gene in man and rat.";
EMBO J. 4:2603-2607(1985).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-125.
PubMed=3487468; DOI=10.1016/0014-5793(86)81425-9;
Minvielle S., Cressent M., Lasmoles F., Jullienne A., Milhaud G.,
Moukhtar M.S.;
"Isolation and partial characterization of the calcitonin gene in a
lower vertebrate. Predicted structure of avian calcitonin gene-related
peptide.";
FEBS Lett. 203:7-10(1986).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin-gene related peptide;
IsoId=P10286-1; Sequence=Displayed;
Name=Calcitonin;
IsoId=P07660-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; X06311; CAA29630.1; -; Genomic_DNA.
EMBL; X06312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X06314; CAA29633.1; -; Genomic_DNA.
EMBL; X03012; CAA26796.1; ALT_TERM; mRNA.
EMBL; D00007; BAA00006.1; -; Genomic_DNA.
PIR; S00154; TCCHRP.
UniGene; Gga.1232; -.
UniGene; Gga.4991; -.
SMR; P10286; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 77
/FTId=PRO_0000004074.
PEPTIDE 80 116 Calcitonin gene-related peptide.
/FTId=PRO_0000004075.
PROPEP 122 125
/FTId=PRO_0000004076.
MOD_RES 116 116 Phenylalanine amide. {ECO:0000250}.
DISULFID 81 86 {ECO:0000250}.
CONFLICT 56 56 D -> E (in Ref. 2; CAA26796).
{ECO:0000305}.
SEQUENCE 125 AA; 13729 MW; E864A2C9AC111F80 CRC64;
MVMLKISSFL AVYALVVCQM DSFQAAPVRP GLESITDRVT LSDYEARRLL NALVKDFIQM
TAEELEQASE GNSVTAQKRA CNTATCVTHR LADFLSRSGG VGKNNFVPTN VGSKAFGRRR
RSVQI


Related products :

Catalog number Product name Quantity
E0876h ELISA kit Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
U0876h CLIA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876h ELISA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
U0472r CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472r ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
U0472m CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0472m ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0472m ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0472r ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0876m ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
U0876r CLIA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
U0876m CLIA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0876r ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
E0876m ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0876r ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
U0472h CLIA Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
E0472h ELISA Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
E0472h ELISA kit Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
E0472c ELISA Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
E0472c ELISA kit Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
U0472c CLIA Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
DL-CGRP-Hu Human Calcitonin Gene Related Peptide (CGRP) ELISA Kit 96T
DL-CGRP-Mu Mouse Calcitonin Gene Related Peptide (CGRP) ELISA Kit 96T
06-271-83138 Calcitonin Gene Related Peptide (CGRP) (8-37) Human - CGRP 1 mg
06-271-83138 Calcitonin Gene Related Peptide (CGRP) (8-37) Human - CGRP 0.5 mg


 

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