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Calcitonin gene-related peptide (CGRP)

 CALCA_PIG               Reviewed;          37 AA.
P30880;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
05-JUL-2017, entry version 69.
RecName: Full=Calcitonin gene-related peptide;
Short=CGRP;
Name=CALCA; Synonyms=CALC;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
PROTEIN SEQUENCE, AND AMIDATION AT PHE-37.
PubMed=3494209; DOI=10.1016/0143-4179(87)90034-5;
Kimura S., Sugita Y., Kanazawa I., Saito A., Goto K.;
"Isolation and amino acid sequence of calcitonin gene related peptide
from porcine spinal cord.";
Neuropeptides 9:75-82(1987).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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SMR; P30880; -.
PRIDE; P30880; -.
HOVERGEN; HBG050783; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IDA:UniProtKB.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
Amidation; Complete proteome; Direct protein sequencing;
Disulfide bond; Hormone; Reference proteome; Secreted.
PEPTIDE 1 37 Calcitonin gene-related peptide.
/FTId=PRO_0000044667.
MOD_RES 37 37 Phenylalanine amide.
{ECO:0000269|PubMed:3494209}.
DISULFID 2 7 {ECO:0000250}.
SEQUENCE 37 AA; 3814 MW; 04CDEB8D248B64BA CRC64;
SCNTATCVTH RLAGLLSRSG GMVKSNFVPT DVGSEAF


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