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Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

 CALCA_RAT               Reviewed;         128 AA.
P01256;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
30-AUG-2017, entry version 129.
RecName: Full=Calcitonin gene-related peptide 1;
AltName: Full=Alpha-type CGRP;
AltName: Full=Calcitonin gene-related peptide I;
Short=CGRP-I;
Flags: Precursor;
Name=Calca; Synonyms=Calc;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE.
PubMed=3872459; DOI=10.1073/pnas.82.7.1994;
Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W.,
Mermod J.-J., Evans R.M., Rosenfeld M.G.;
"Alternative RNA processing events in human calcitonin/calcitonin
gene-related peptide gene expression.";
Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6283379; DOI=10.1038/298240a0;
Amara S.G., Jonas V., Rosenfeld M.G., Ong E.S., Evans R.M.;
"Alternative RNA processing in calcitonin gene expression generates
mRNAs encoding different polypeptide products.";
Nature 298:240-244(1982).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2994212; DOI=10.1126/science.2994212;
Amara S.G., Arriza J.L., Leff S.E., Swanson L.W., Evans R.M.,
Rosenfeld M.G.;
"Expression in brain of a messenger RNA encoding a novel neuropeptide
homologous to calcitonin gene-related peptide.";
Science 229:1094-1097(1985).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin-gene related peptide I;
IsoId=P01256-1; Sequence=Displayed;
Name=Calcitonin;
IsoId=P01257-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; L29188; AAB59682.1; -; Genomic_DNA.
EMBL; L00109; AAB59682.1; JOINED; Genomic_DNA.
EMBL; L00110; AAB59682.1; JOINED; Genomic_DNA.
EMBL; V01231; CAA24541.1; -; mRNA.
EMBL; M11597; AAA40847.1; -; mRNA.
PIR; A01524; TCRTR.
PIR; B44173; B44173.
RefSeq; NP_001029127.1; NM_001033955.1.
RefSeq; NP_001029128.1; NM_001033956.1.
UniGene; Rn.90085; -.
SMR; P01256; -.
MINT; MINT-1504942; -.
BindingDB; P01256; -.
ChEMBL; CHEMBL5735; -.
GeneID; 24241; -.
KEGG; rno:24241; -.
CTD; 796; -.
RGD; 2254; Calca.
HOVERGEN; HBG031362; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0031716; F:calcitonin receptor binding; TAS:RGD.
GO; GO:0005184; F:neuropeptide hormone activity; TAS:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
GO; GO:0006954; P:inflammatory response; IEP:RGD.
GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
GO; GO:0045986; P:negative regulation of smooth muscle contraction; IMP:RGD.
GO; GO:0008016; P:regulation of heart contraction; IDA:RGD.
GO; GO:0042311; P:vasodilation; IDA:RGD.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 25
PROPEP 26 80
/FTId=PRO_0000004065.
PEPTIDE 83 119 Calcitonin gene-related peptide 1.
/FTId=PRO_0000004066.
PROPEP 125 128
/FTId=PRO_0000004067.
MOD_RES 119 119 Phenylalanine amide. {ECO:0000250}.
DISULFID 84 89 {ECO:0000250}.
CONFLICT 40 40 Missing (in Ref. 2; AAB59682/CAA24541 and
3; AAA40847). {ECO:0000305}.
CONFLICT 51 51 Missing (in Ref. 2; AAB59682/CAA24541 and
3; AAA40847). {ECO:0000305}.
CONFLICT 70 70 Q -> EEQ (in Ref. 2; AAB59682/CAA24541
and 3; AAA40847). {ECO:0000305}.
CONFLICT 99 99 S -> R (in Ref. 3; AAA40847).
{ECO:0000305}.
SEQUENCE 128 AA; 13948 MW; 75D14869C17078D3 CRC64;
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAA TLSEEEARLL LAALVQNYMQ
MKVRELEQEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG
RRRRDLQA


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