Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

 CALCA_HUMAN             Reviewed;         128 AA.
P06881; Q93048; Q9UCP0;
01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 3.
27-SEP-2017, entry version 174.
RecName: Full=Calcitonin gene-related peptide 1;
AltName: Full=Alpha-type CGRP;
AltName: Full=Calcitonin gene-related peptide I;
Short=CGRP-I;
Flags: Precursor;
Name=CALCA; Synonyms=CALC1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-57.
PubMed=3872459; DOI=10.1073/pnas.82.7.1994;
Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W.,
Mermod J.-J., Evans R.M., Rosenfeld M.G.;
"Alternative RNA processing events in human calcitonin/calcitonin
gene-related peptide gene expression.";
Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-57.
PubMed=2571128; DOI=10.1093/nar/17.17.6999;
Broad P.M., Symes A.J., Thakker R.V., Craig R.K.;
"Structure and methylation of the human calcitonin/alpha-CGRP gene.";
Nucleic Acids Res. 17:6999-7011(1989).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 48-119, AND VARIANT ASP-57.
PubMed=6148938; DOI=10.1016/0006-291X(84)90278-X;
Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A.,
Baylin S.B.;
"Structure and expression of a gene encoding human calcitonin and
calcitonin gene related peptide.";
Biochem. Biophys. Res. Commun. 123:648-655(1984).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 76-128.
PubMed=2408883;
Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D.,
Pettengill O.S., Craig R.K.;
"Expression of the human calcitonin/CGRP gene in lung and thyroid
carcinoma.";
EMBO J. 4:715-724(1985).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-128.
TISSUE=Thyroid carcinoma;
PubMed=6610687; DOI=10.1210/jcem-59-2-358;
Steenbergh P.H., Hoppener J.W., Zandberg J., de Ven W.J., Jansz H.S.,
Lips C.J.;
"Calcitonin gene related peptide coding sequence is conserved in the
human genome and is expressed in medullary thyroid carcinoma.";
J. Clin. Endocrinol. Metab. 59:358-360(1984).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-128.
PubMed=3034287;
Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M.,
Al-Kazwini S.J., Holman J.J., Marshall I.;
"Expression and function of the human calcitonin/alpha-CGRP gene in
health and disease.";
Biochem. Soc. Symp. 52:91-105(1986).
[8]
PROTEIN SEQUENCE OF 83-119, AMIDATION AT PHE-119, AND DISULFIDE BOND.
PubMed=6609312; DOI=10.1038/308746a0;
Morris H.R., Panico M., Etienne T., Tippins J., Girgis S.I.,
McIntyre I.;
"Isolation and characterization of human calcitonin gene-related
peptide.";
Nature 308:746-748(1984).
[9]
PROTEIN SEQUENCE OF 83-117.
PubMed=3492492;
Petermann J.B., Born W., Chang J.Y., Fischer J.A.;
"Identification in the human central nervous system, pituitary, and
thyroid of a novel calcitonin gene-related peptide, and partial amino
acid sequence in the spinal cord.";
J. Biol. Chem. 262:542-545(1987).
[10]
PROTEIN SEQUENCE OF 83-108, AND FUNCTION.
TISSUE=Pheochromocytoma;
PubMed=1318039; DOI=10.1016/S0006-291X(05)80966-0;
Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.;
"Isolation and characterization of peptides which act on rat
platelets, from a pheochromocytoma.";
Biochem. Biophys. Res. Commun. 185:134-141(1992).
[11]
STRUCTURE BY NMR OF CGRP.
PubMed=1988044; DOI=10.1021/bi00216a036;
Breeze A.L., Harvey T.S., Bazzo R., Campbell I.D.;
"Solution structure of human calcitonin gene-related peptide by 1H NMR
and distance geometry with restrained molecular dynamics.";
Biochemistry 30:575-582(1991).
[12]
STRUCTURE BY NMR OF CGRP.
PubMed=2039456; DOI=10.1042/bj2750785;
Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M.,
Price N.C.;
"Solution structures of calcitonin-gene-related-peptide analogues of
calcitonin-gene-related peptide and amylin.";
Biochem. J. 275:785-788(1991).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role. It also elevates platelet cAMP.
{ECO:0000269|PubMed:1318039}.
-!- INTERACTION:
Q16602:CALCRL; NbExp=2; IntAct=EBI-962928, EBI-962878;
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=3;
IsoId=P06881-1; Sequence=Displayed;
Name=1;
IsoId=P01258-1; Sequence=External;
Name=2;
IsoId=P01258-2; Sequence=External;
Note=May be produced at very low levels due to a premature stop
codon in the mRNA, leading to nonsense-mediated mRNA decay.;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M12667; AAA51914.1; -; Genomic_DNA.
EMBL; M12664; AAA51914.1; JOINED; Genomic_DNA.
EMBL; M12665; AAA51914.1; JOINED; Genomic_DNA.
EMBL; X15943; CAA34070.1; -; Genomic_DNA.
EMBL; AC090835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; K03512; AAA52011.1; -; mRNA.
EMBL; X02330; CAA26190.1; -; mRNA.
EMBL; M28637; AAA52012.1; -; Genomic_DNA.
EMBL; M26094; AAA51912.1; -; Genomic_DNA.
CCDS; CCDS31432.1; -. [P06881-1]
PIR; S07644; TCHUR.
RefSeq; NP_001029125.1; NM_001033953.2.
UniGene; Hs.37058; -.
PDB; 1LS7; Model; -; A=1-125.
PDBsum; 1LS7; -.
ProteinModelPortal; P06881; -.
SMR; P06881; -.
BioGrid; 107247; 11.
IntAct; P06881; 3.
BindingDB; P06881; -.
ChEMBL; CHEMBL5293; -.
DrugBank; DB05760; MK-0974.
DrugBank; DB04869; Olcegepant.
TCDB; 1.C.49.1.2; the cytotoxic amylin (amylin) family.
iPTMnet; P06881; -.
BioMuta; CYP2R1; -.
DMDM; 308153625; -.
PeptideAtlas; P06881; -.
PRIDE; P06881; -.
DNASU; 796; -.
Ensembl; ENST00000361010; ENSP00000354286; ENSG00000110680.
Ensembl; ENST00000486207; ENSP00000417833; ENSG00000110680.
GeneID; 796; -.
UCSC; uc001mlt.2; human. [P06881-1]
CTD; 796; -.
DisGeNET; 796; -.
EuPathDB; HostDB:ENSG00000110680.12; -.
GeneCards; CALCA; -.
HGNC; HGNC:1437; CALCA.
MIM; 114130; gene.
neXtProt; NX_P06881; -.
PharmGKB; PA26029; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-419812; Calcitonin-like ligand receptors.
GenomeRNAi; 796; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000110680; -.
CleanEx; HS_CALCA; -.
ExpressionAtlas; P06881; baseline and differential.
Genevisible; P06881; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0032403; F:protein complex binding; IDA:UniProtKB.
GO; GO:0005102; F:receptor binding; IDA:UniProtKB.
GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:UniProtKB.
GO; GO:0097647; P:amylin receptor signaling pathway; IGI:ARUK-UCL.
GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB.
GO; GO:0019732; P:antifungal humoral response; IDA:UniProtKB.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO; GO:0043542; P:endothelial cell migration; IDA:UniProtKB.
GO; GO:0001935; P:endothelial cell proliferation; IDA:UniProtKB.
GO; GO:0002031; P:G-protein coupled receptor internalization; IDA:UniProtKB.
GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IDA:UniProtKB.
GO; GO:0045776; P:negative regulation of blood pressure; IDA:MGI.
GO; GO:0045779; P:negative regulation of bone resorption; IDA:UniProtKB.
GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IDA:UniProtKB.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IDA:UniProtKB.
GO; GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; IDA:MGI.
GO; GO:0097755; P:positive regulation of blood vessel diameter; IDA:UniProtKB.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IDA:UniProtKB.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; IGI:ARUK-UCL.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IDA:UniProtKB.
GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; IDA:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:UniProtKB.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IDA:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO; GO:0008217; P:regulation of blood pressure; NAS:UniProtKB.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO; GO:0001878; P:response to yeast; IDA:UniProtKB.
GO; GO:0001944; P:vasculature development; IDA:UniProtKB.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Amidation;
Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Hormone; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 80
/FTId=PRO_0000004053.
PEPTIDE 83 119 Calcitonin gene-related peptide 1.
/FTId=PRO_0000004054.
PROPEP 125 128
/FTId=PRO_0000004055.
MOD_RES 119 119 Phenylalanine amide.
{ECO:0000269|PubMed:6609312}.
DISULFID 84 89 {ECO:0000269|PubMed:6609312}.
VARIANT 57 57 N -> D (in dbSNP:rs5239).
{ECO:0000269|PubMed:2571128,
ECO:0000269|PubMed:3872459,
ECO:0000269|PubMed:6148938}.
/FTId=VAR_048584.
SEQUENCE 128 AA; 13898 MW; 2AA1A9AC3060D9B6 CRC64;
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQNYVQ
MKASELEQEQ EREGSRIIAQ KRACDTATCV THRLAGLLSR SGGVVKNNFV PTNVGSKAFG
RRRRDLQA


Related products :

Catalog number Product name Quantity
U0472r CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472r ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472m ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
U0472m CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0472r ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472m ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0876h ELISA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876h ELISA kit Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
U0876h CLIA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0472h ELISA kit Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
U0472h CLIA Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
E0472h ELISA Alpha-type CGRP,CALC1,CALCA,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Homo sapiens 96T
U0876r CLIA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
E0876m ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0876r ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
E0876r ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
E0876m ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
U0876m CLIA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0472c ELISA kit Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
E0472c ELISA Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
U0472c CLIA Alpha-type CGRP,CALC,CALCA,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,Canis familiaris,Canis lupus familiaris,CCALCI,CGRP-I,Dog 96T
DL-CGRP-Mu Mouse Calcitonin Gene Related Peptide (CGRP) ELISA Kit 96T
DL-CGRP-Hu Human Calcitonin Gene Related Peptide (CGRP) ELISA Kit 96T
06-271-83138 Calcitonin Gene Related Peptide (CGRP) (8-37) Human - CGRP 1 mg
06-271-83138 Calcitonin Gene Related Peptide (CGRP) (8-37) Human - CGRP 0.5 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur