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Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

 CALCA_MOUSE             Reviewed;         128 AA.
Q99JA0;
21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
25-OCT-2017, entry version 131.
RecName: Full=Calcitonin gene-related peptide 1;
AltName: Full=Alpha-type CGRP;
AltName: Full=Calcitonin gene-related peptide I;
Short=CGRP-I;
Flags: Precursor;
Name=Calca; Synonyms=Calc;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Sarasa M., Catalan J., Aramayona J., Sorribas V.;
"Mouse CGRP precursor is highly homologous to that of the rat.";
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=11761712; DOI=10.3109/10425170109047567;
Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.;
"Structure of the mouse calcitonin/calcitonin gene-related peptide
alpha and beta genes.";
DNA Seq. 12:131-135(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
PubMed=18544925; DOI=10.1159/000124380;
Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
Nishibori M., Hamano K., Minamino N., Yasue H.;
"Genomic organization, expression and evolution of porcine CRSP1, 2,
and 3.";
Cytogenet. Genome Res. 121:41-49(2008).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role. It also elevates platelet cAMP (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin-gene related peptide I;
IsoId=Q99JA0-1; Sequence=Displayed;
Name=Calcitonin;
IsoId=P70160-1; Sequence=External;
-!- TISSUE SPECIFICITY: Detected in nerve cells of cerebrum,
hippocampus and pons/midbrain in newborns, and only in nerve cells
of pons/midbrain in adult. {ECO:0000269|PubMed:18544925}.
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; AF330212; AAK06841.1; -; mRNA.
EMBL; AF325522; AAK18181.1; -; Genomic_DNA.
EMBL; AF325521; AAK18181.1; JOINED; Genomic_DNA.
EMBL; BC028771; AAH28771.1; -; mRNA.
CCDS; CCDS21762.1; -. [Q99JA0-1]
RefSeq; NP_001029126.1; NM_001033954.3. [Q99JA0-1]
RefSeq; NP_001276373.1; NM_001289444.1. [Q99JA0-1]
RefSeq; XP_011239962.1; XM_011241660.2. [Q99JA0-1]
UniGene; Mm.4361; -.
ProteinModelPortal; Q99JA0; -.
SMR; Q99JA0; -.
DIP; DIP-60043N; -.
IntAct; Q99JA0; 2.
PRIDE; Q99JA0; -.
Ensembl; ENSMUST00000032906; ENSMUSP00000032906; ENSMUSG00000030669. [Q99JA0-1]
GeneID; 12310; -.
KEGG; mmu:12310; -.
UCSC; uc009jif.2; mouse. [Q99JA0-1]
CTD; 796; -.
MGI; MGI:2151253; Calca.
GeneTree; ENSGT00390000010511; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
OMA; ESMSERV; -.
Reactome; R-MMU-418555; G alpha (s) signalling events.
Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000030669; -.
CleanEx; MM_CALCA; -.
ExpressionAtlas; Q99JA0; baseline and differential.
Genevisible; Q99JA0; MM.
GO; GO:0030424; C:axon; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005576; C:extracellular region; IDA:MGI.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005622; C:intracellular; IDA:MGI.
GO; GO:0043005; C:neuron projection; IDA:MGI.
GO; GO:0043025; C:neuronal cell body; IDA:MGI.
GO; GO:0043195; C:terminal bouton; IDA:MGI.
GO; GO:0031716; F:calcitonin receptor binding; IDA:MGI.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0005102; F:receptor binding; IDA:MGI.
GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:MGI.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IGI:MGI.
GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI.
GO; GO:0006874; P:cellular calcium ion homeostasis; IGI:MGI.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI.
GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI.
GO; GO:0007631; P:feeding behavior; IDA:MGI.
GO; GO:0006954; P:inflammatory response; IDA:MGI.
GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
GO; GO:0031645; P:negative regulation of neurological system process; IMP:MGI.
GO; GO:0030279; P:negative regulation of ossification; IMP:MGI.
GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:MGI.
GO; GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; ISA:MGI.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
GO; GO:0045778; P:positive regulation of ossification; IMP:MGI.
GO; GO:0002027; P:regulation of heart rate; IMP:MGI.
GO; GO:0009408; P:response to heat; IMP:MGI.
GO; GO:0048265; P:response to pain; IMP:MGI.
GO; GO:0048240; P:sperm capacitation; ISA:MGI.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 80 {ECO:0000250}.
/FTId=PRO_0000004059.
PEPTIDE 83 119 Calcitonin gene-related peptide 1.
/FTId=PRO_0000004060.
PROPEP 125 128 {ECO:0000250}.
/FTId=PRO_0000004061.
MOD_RES 119 119 Phenylalanine amide. {ECO:0000250}.
DISULFID 84 89 {ECO:0000250}.
SEQUENCE 128 AA; 14065 MW; 83BB0E36C8B4239E CRC64;
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK
ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG
RRRRDLQA


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