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Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

 CALCA_CANLF             Reviewed;         128 AA.
Q9MYV1;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-JUN-2017, entry version 92.
RecName: Full=Calcitonin gene-related peptide 1;
AltName: Full=Alpha-type CGRP;
AltName: Full=Calcitonin gene-related peptide I;
Short=CGRP-I;
Flags: Precursor;
Name=CALCA; Synonyms=CALC, CCALCI;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10967131; DOI=10.1007/s003350010157;
Wende S., Krempler A., Breen M., Brunnberg L., Brenig B.;
"Molecular analysis and chromosomal assignment of the canine CALC-
I/alpha-CGRP gene.";
Mamm. Genome 11:736-740(2000).
[2]
PROTEIN SEQUENCE OF 26-50.
TISSUE=Thyroid;
PubMed=1758974; DOI=10.1016/0167-0115(91)90082-R;
Mol J.A., Kwant M.M., Arnold I.C.J., Hazewinkel H.A.W.;
"Elucidation of the sequence of canine (pro)-calcitonin. A molecular
biological and protein chemical approach.";
Regul. Pept. 35:189-195(1991).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role. It also elevates platelet cAMP (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin-gene related peptide I;
IsoId=Q9MYV1-1; Sequence=Displayed;
Name=Calcitonin;
IsoId=P41547-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; AJ271090; CAB97487.1; -; Genomic_DNA.
RefSeq; NP_001300719.1; NM_001313790.1. [Q9MYV1-1]
RefSeq; NP_001300720.1; NM_001313791.1. [Q9MYV1-1]
UniGene; Cfa.3806; -.
UniGene; Cfa.45595; -.
ProteinModelPortal; Q9MYV1; -.
SMR; Q9MYV1; -.
Ensembl; ENSCAFT00000013581; ENSCAFP00000012566; ENSCAFG00000008562. [Q9MYV1-1]
GeneID; 403946; -.
CTD; 796; -.
GeneTree; ENSGT00390000010511; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
Proteomes; UP000002254; Chromosome 21.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Direct protein sequencing; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000269|PubMed:1758974}.
PROPEP 26 80 {ECO:0000250}.
/FTId=PRO_0000004041.
PEPTIDE 83 119 Calcitonin gene-related peptide 1.
/FTId=PRO_0000004042.
PROPEP 125 128 {ECO:0000250}.
/FTId=PRO_0000004043.
MOD_RES 119 119 Phenylalanine amide. {ECO:0000250}.
DISULFID 84 89 {ECO:0000250}.
CONFLICT 45 45 E -> K (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 49 49 L -> N (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 128 AA; 13874 MW; 72331258DB8CB564 CRC64;
MGLWKSSPFL AFSILVLCQA GGLQAAPFRS ALEGLPDPTA LSEKEGRLLL AALVKAYVQR
KNELEQEQEQ ETEGSSITAQ KRSCNTATCV THRLAGLLSR SGGVVKNNFV PTNVGSEAFG
RRRRDLRA


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