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Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I)

 CALCA_HORSE             Reviewed;         127 AA.
Q9N0T2;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
10-MAY-2017, entry version 74.
RecName: Full=Calcitonin gene-related peptide 1;
AltName: Full=Alpha-type CGRP;
AltName: Full=Calcitonin gene-related peptide I;
Short=CGRP-I;
Flags: Precursor;
Name=CALCA; Synonyms=CALC;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12581884; DOI=10.1016/S0303-7207(02)00289-7;
Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
"Molecular cloning and expression of equine calcitonin, calcitonin
gene-related peptide-I, and calcitonin gene-related peptide-II.";
Mol. Cell. Endocrinol. 199:119-128(2003).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role. It also elevates platelet cAMP (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Calcitonin-gene related peptide I;
IsoId=Q9N0T2-1; Sequence=Displayed;
Name=Calcitonin;
IsoId=Q9N0V5-1; Sequence=External;
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; AF257471; AAF70200.1; -; mRNA.
RefSeq; NP_001075323.1; NM_001081854.3.
RefSeq; NP_001078893.1; NM_001085424.1. [Q9N0T2-1]
UniGene; Eca.12754; -.
SMR; Q9N0T2; -.
GeneID; 100033906; -.
KEGG; ecb:100033906; -.
CTD; 796; -.
HOVERGEN; HBG031362; -.
KO; K12332; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 79 {ECO:0000250}.
/FTId=PRO_0000004047.
CHAIN 82 118 Calcitonin gene-related peptide 1.
/FTId=PRO_0000004048.
PROPEP 124 127 {ECO:0000250}.
/FTId=PRO_0000004049.
MOD_RES 118 118 Serine amide. {ECO:0000250}.
DISULFID 83 88 {ECO:0000250}.
SEQUENCE 127 AA; 13864 MW; BA570B2AB49A6730 CRC64;
MGFWKFSPFL PLSILVLYQV GIIQAAPFRS ALESLPDPAV LPEEESRLLL AALVKDYVQM
KVRALEQEQE TGGASITAQK RSCNTASCLT HRLAGLLSSA GSMANSNLLP TEMGFKVSGR
RRRDLQA


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