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Calcitonin gene-related peptide 2 (Beta-type CGRP) (Beta-CGRP) (Calcitonin gene-related peptide II) (CGRP-II)

 CALCB_HUMAN             Reviewed;         127 AA.
P10092; A8K573; D3DQX4; Q569I0; Q9UCN9;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
27-SEP-2017, entry version 155.
RecName: Full=Calcitonin gene-related peptide 2;
AltName: Full=Beta-type CGRP;
Short=Beta-CGRP;
AltName: Full=Calcitonin gene-related peptide II;
Short=CGRP-II;
Flags: Precursor;
Name=CALCB; Synonyms=CALC2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3492393; DOI=10.1016/0014-5793(86)81091-2;
Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Visser A.,
Lips C.J.M., Jansz H.S.;
"Structure and expression of the human calcitonin/CGRP genes.";
FEBS Lett. 209:97-103(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 56-127.
PubMed=2985435; DOI=10.1016/0014-5793(85)80820-6;
Steenbergh P.H., Hoeppener J.W.M., Zandberg J., Lips C.J.M.,
Jansz H.S.;
"A second human calcitonin/CGRP gene.";
FEBS Lett. 183:403-407(1985).
[6]
PROTEIN SEQUENCE OF 82-108.
PubMed=3492492;
Petermann J.B., Born W., Chang J.Y., Fischer J.A.;
"Identification in the human central nervous system, pituitary, and
thyroid of a novel calcitonin gene-related peptide, and partial amino
acid sequence in the spinal cord.";
J. Biol. Chem. 262:542-545(1987).
[7]
PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, AND
DISULFIDE BOND.
TISSUE=Spinal cord;
PubMed=2322288; DOI=10.1016/0006-291X(90)90621-S;
Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M.,
McIntyre I.;
"Isolation, purification and characterization of beta-hCGRP from human
spinal cord.";
Biochem. Biophys. Res. Commun. 167:993-1000(1990).
[8]
PROTEIN SEQUENCE OF 82-104.
TISSUE=Pheochromocytoma;
PubMed=1318039; DOI=10.1016/S0006-291X(05)80966-0;
Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.;
"Isolation and characterization of peptides which act on rat
platelets, from a pheochromocytoma.";
Biochem. Biophys. Res. Commun. 185:134-141(1992).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; X04855; CAC05295.1; -; Genomic_DNA.
EMBL; X04857; CAC05295.1; JOINED; Genomic_DNA.
EMBL; X04861; CAC05295.1; JOINED; Genomic_DNA.
EMBL; AK291188; BAF83877.1; -; mRNA.
EMBL; CH471064; EAW68466.1; -; Genomic_DNA.
EMBL; CH471064; EAW68467.1; -; Genomic_DNA.
EMBL; BC092468; AAH92468.1; -; mRNA.
EMBL; X02404; CAA26249.1; -; mRNA.
CCDS; CCDS7820.1; -.
PIR; A25864; A25864.
PIR; I37232; I37232.
RefSeq; NP_000719.1; NM_000728.3.
UniGene; Hs.534305; -.
ProteinModelPortal; P10092; -.
SMR; P10092; -.
BioGrid; 107248; 3.
IntAct; P10092; 1.
STRING; 9606.ENSP00000346017; -.
ChEMBL; CHEMBL3832947; -.
DrugBank; DB05760; MK-0974.
iPTMnet; P10092; -.
PhosphoSitePlus; P10092; -.
BioMuta; CALCB; -.
DMDM; 115487; -.
PaxDb; P10092; -.
PeptideAtlas; P10092; -.
PRIDE; P10092; -.
Ensembl; ENST00000324229; ENSP00000346017; ENSG00000175868.
Ensembl; ENST00000533448; ENSP00000433490; ENSG00000175868.
GeneID; 797; -.
KEGG; hsa:797; -.
UCSC; uc001mlx.2; human.
CTD; 797; -.
DisGeNET; 797; -.
EuPathDB; HostDB:ENSG00000175868.13; -.
GeneCards; CALCB; -.
HGNC; HGNC:1438; CALCB.
MIM; 114160; gene.
neXtProt; NX_P10092; -.
OpenTargets; ENSG00000175868; -.
PharmGKB; PA26030; -.
eggNOG; ENOG410IYZP; Eukaryota.
eggNOG; ENOG410YIU3; LUCA.
GeneTree; ENSGT00390000010511; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
InParanoid; P10092; -.
PhylomeDB; P10092; -.
TreeFam; TF333069; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-419812; Calcitonin-like ligand receptors.
GenomeRNAi; 797; -.
PMAP-CutDB; P10092; -.
PRO; PR:P10092; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000175868; -.
CleanEx; HS_CALCB; -.
ExpressionAtlas; P10092; baseline and differential.
Genevisible; P10092; HS.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005184; F:neuropeptide hormone activity; TAS:ProtInc.
GO; GO:0006874; P:cellular calcium ion homeostasis; TAS:ProtInc.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Hormone;
Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 79
/FTId=PRO_0000004086.
PEPTIDE 82 118 Calcitonin gene-related peptide 2.
/FTId=PRO_0000004087.
PROPEP 124 127
/FTId=PRO_0000004088.
MOD_RES 118 118 Phenylalanine amide.
{ECO:0000269|PubMed:2322288}.
DISULFID 83 88 {ECO:0000269|PubMed:2322288}.
CONFLICT 73 73 G -> S (in Ref. 5; CAA26249).
{ECO:0000305}.
SEQUENCE 127 AA; 13706 MW; B0A71A063CD5ACE7 CRC64;
MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM
KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR
RRRDLQA


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