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Calcitonin gene-related peptide 2 (Beta-type CGRP) (Calcitonin gene-related peptide II) (CGRP-II)

 CALCB_MOUSE             Reviewed;         130 AA.
Q99MP3;
21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
10-MAY-2017, entry version 94.
RecName: Full=Calcitonin gene-related peptide 2;
AltName: Full=Beta-type CGRP;
AltName: Full=Calcitonin gene-related peptide II;
Short=CGRP-II;
Flags: Precursor;
Name=Calcb;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=11761712; DOI=10.3109/10425170109047567;
Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.;
"Structure of the mouse calcitonin/calcitonin gene-related peptide
alpha and beta genes.";
DNA Seq. 12:131-135(2001).
[2]
TISSUE SPECIFICITY.
PubMed=18544925; DOI=10.1159/000124380;
Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
Nishibori M., Hamano K., Minamino N., Yasue H.;
"Genomic organization, expression and evolution of porcine CRSP1, 2,
and 3.";
Cytogenet. Genome Res. 121:41-49(2008).
-!- FUNCTION: CGRP induces vasodilation. It dilates a variety of
vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or
neuromodulator role (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Detected in nerve cells of cerebrum,
hippocampus and pons/midbrain in newborns, and only in nerve cells
of pons/midbrain in adult. {ECO:0000269|PubMed:18544925}.
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; AF325526; AAK16431.1; -; Genomic_DNA.
EMBL; AF325524; AAK16431.1; JOINED; Genomic_DNA.
CCDS; CCDS21764.1; -.
UniGene; Mm.273838; -.
ProteinModelPortal; Q99MP3; -.
SMR; Q99MP3; -.
STRING; 10090.ENSMUSP00000032902; -.
PhosphoSitePlus; Q99MP3; -.
PaxDb; Q99MP3; -.
PRIDE; Q99MP3; -.
MGI; MGI:2151254; Calcb.
eggNOG; ENOG410IYZP; Eukaryota.
eggNOG; ENOG410YIU3; LUCA.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG031362; -.
InParanoid; Q99MP3; -.
PhylomeDB; Q99MP3; -.
PRO; PR:Q99MP3; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_CALCB; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR015476; Calcitonin_gene-rel_peptide.
InterPro; IPR001693; Calcitonin_peptide-like.
PANTHER; PTHR10505; PTHR10505; 1.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00817; CALCITONINB.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 26 {ECO:0000255}.
PROPEP 27 82 {ECO:0000250}.
/FTId=PRO_0000004089.
PEPTIDE 84 120 Calcitonin gene-related peptide 2.
/FTId=PRO_0000004090.
PROPEP 127 130 {ECO:0000250}.
/FTId=PRO_0000004091.
MOD_RES 120 120 Phenylalanine amide. {ECO:0000250}.
DISULFID 85 90 {ECO:0000250}.
SEQUENCE 130 AA; 14623 MW; 97299244E8F6C536 CRC64;
MDFWKFFPFL ALSTIWVLCL ASSLQAAPFR SALESSLDLG TLGDQEKHLL LAALMQDYEQ
MKARKLEQEE QETKGSRVTA QKRSCNTATC VTHRLADLLS RSGGVLKDNF VPTDVGSEAF
GRRRRRDLQA


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