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Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)

 CALRL_DANRE             Reviewed;         470 AA.
Q68EK2; A1L211; B0S6C2;
05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
25-OCT-2017, entry version 88.
RecName: Full=Calcitonin gene-related peptide type 1 receptor;
Short=CGRP type 1 receptor;
AltName: Full=Calcitonin receptor-like receptor;
Flags: Precursor;
Name=calcrla; Synonyms=calcrl; ORFNames=si:dkey-249o24.2, zgc:100872;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Embryo;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) (By
similarity). Receptor specificity may be modulated by accessory
proteins. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAQ13571.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; BX470245; CAQ13571.1; ALT_INIT; Genomic_DNA.
EMBL; BC080226; AAH80226.1; -; mRNA.
EMBL; BC129300; AAI29301.1; -; mRNA.
RefSeq; NP_001004010.1; NM_001004010.1.
UniGene; Dr.86963; -.
ProteinModelPortal; Q68EK2; -.
SMR; Q68EK2; -.
STRING; 7955.ENSDARP00000118958; -.
PaxDb; Q68EK2; -.
GeneID; 445508; -.
KEGG; dre:445508; -.
CTD; 445508; -.
ZFIN; ZDB-GENE-040822-26; calcrla.
eggNOG; KOG4564; Eukaryota.
eggNOG; ENOG410XRS2; LUCA.
HOGENOM; HOG000230695; -.
InParanoid; Q68EK2; -.
KO; K04577; -.
PhylomeDB; Q68EK2; -.
TreeFam; TF315710; -.
PRO; PR:Q68EK2; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro.
GO; GO:0001525; P:angiogenesis; IMP:ZFIN.
GO; GO:0048844; P:artery morphogenesis; IMP:ZFIN.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0001756; P:somitogenesis; IGI:ZFIN.
CDD; cd15274; 7tmB1_calcitonin_R; 1.
Gene3D; 4.10.1240.10; -; 1.
InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
InterPro; IPR036445; GPCR_2_extracell_dom_sf.
InterPro; IPR001879; GPCR_2_extracellular_dom.
InterPro; IPR000832; GPCR_2_secretin-like.
InterPro; IPR017983; GPCR_2_secretin-like_CS.
Pfam; PF00002; 7tm_2; 1.
Pfam; PF02793; HRM; 1.
PRINTS; PR01351; CGRPRECEPTOR.
PRINTS; PR01350; CTRFAMILY.
PRINTS; PR00249; GPCRSECRETIN.
SMART; SM00008; HormR; 1.
SUPFAM; SSF111418; SSF111418; 1.
PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Signal; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 470 Calcitonin gene-related peptide type 1
receptor.
/FTId=PRO_0000373833.
TOPO_DOM 24 154 Extracellular. {ECO:0000255}.
TRANSMEM 155 174 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 175 181 Cytoplasmic. {ECO:0000255}.
TRANSMEM 182 201 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 202 221 Extracellular. {ECO:0000255}.
TRANSMEM 222 244 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 245 261 Cytoplasmic. {ECO:0000255}.
TRANSMEM 262 281 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 282 297 Extracellular. {ECO:0000255}.
TRANSMEM 298 321 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 322 344 Cytoplasmic. {ECO:0000255}.
TRANSMEM 345 362 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 363 374 Extracellular. {ECO:0000255}.
TRANSMEM 375 396 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 397 470 Cytoplasmic. {ECO:0000255}.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 74 74 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 126 126 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 131 131 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 295 295 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 56 82 {ECO:0000250}.
DISULFID 73 113 {ECO:0000250}.
DISULFID 96 135 {ECO:0000250}.
CONFLICT 82 82 C -> R (in Ref. 2; AAI29301).
{ECO:0000305}.
CONFLICT 113 113 C -> R (in Ref. 2; AAI29301).
{ECO:0000305}.
CONFLICT 285 285 Y -> F (in Ref. 2; AAI29301).
{ECO:0000305}.
CONFLICT 335 335 K -> E (in Ref. 1; CAQ13571 and 2;
AAI29301). {ECO:0000305}.
CONFLICT 469 469 F -> L (in Ref. 1; CAQ13571).
{ECO:0000305}.
SEQUENCE 470 AA; 54102 MW; 7CB0C91BF7AE4921 CRC64;
MTASCWTICL FLLGSVTEFI VLASPEVNES QQQHPQNVYH DIGVTRNKIV TAQFECYQKI
MKDNSQDRRG PVCNRTWDGW LCWDDTEAGI TSEQHCPDYF QDFDPTEMVT KICTESGQWF
LHPESNRTWT NFTRCNLHTT EGRRTAMNLF YLALIGHGLS LTSLFISLGI FFHFKSLSCQ
RITLHKNLFF SFVLNSIITI IWLTAVANNQ ELVQQNPISC KISQFIHLYI FGCNYFWMLC
EGIYLHTLIV VAVFAEKQHL MWYYLLGWGF PLIPATIHAV ARSYYYNDNC WISSNTSLLY
IIHGPICAAM LVNLFFLLNI VRVLITKLKV THQAKSSLYM KAVRATLILV PLLGIQYVLL
PYKPSGRVSA EIYDYIMHIL MHYQGLLVAT IFCFFNGEVQ AVLRRHWNQY RIQFGSTITQ
SDALRSASYT ASSITEVQGC YSIDGHTEHL NGKNYHDFDN AIIKPENPFA


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