Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)

 CALRL_MOUSE             Reviewed;         463 AA.
Q9R1W5; Q9QXH8; Q9WUP2;
26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
26-SEP-2003, sequence version 2.
25-OCT-2017, entry version 142.
RecName: Full=Calcitonin gene-related peptide type 1 receptor;
Short=CGRP type 1 receptor;
AltName: Full=Calcitonin receptor-like receptor;
Flags: Precursor;
Name=Calcrl; Synonyms=Crlr;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Spleen;
PubMed=12147211; DOI=10.1054/npep.2002.0871;
Miyauchi K., Tadotsu N., Hayashi T., Ono Y., Tokoyoda K.,
Tsujikawa K., Yamamoto H.;
"Molecular cloning and characterization of mouse calcitonin gene-
related peptide receptor.";
Neuropeptides 36:22-33(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Derst C., Preisig-Mueller R., Gerhardus J., Daut J.;
"Cloning and sequencing of mouse CGRP/adrenomedullin receptor
subunits.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Lung;
PubMed=10777702; DOI=10.1006/bbrc.2000.2606;
Ono Y., Okano I., Kojima M., Okada K., Kangawa K.;
"Decreased gene expression of adrenomedullin receptor in mouse lungs
during sepsis.";
Biochem. Biophys. Res. Commun. 271:197-202(2000).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419 AND SER-444, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP)
together with RAMP1 and receptor for adrenomedullin together with
RAMP2 or RAMP3. The activity of this receptor is mediated by G
proteins which activate adenylyl cyclase (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed predominantly in the lung, thymus,
heart and brain. {ECO:0000269|PubMed:10777702,
ECO:0000269|PubMed:12147211}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB015595; BAA76492.1; -; mRNA.
EMBL; AF146525; AAD35021.1; -; mRNA.
EMBL; AF209905; AAF21037.1; -; mRNA.
CCDS; CCDS16184.1; -.
RefSeq; NP_061252.2; NM_018782.2.
RefSeq; XP_006499981.1; XM_006499918.3.
UniGene; Mm.75467; -.
ProteinModelPortal; Q9R1W5; -.
SMR; Q9R1W5; -.
STRING; 10090.ENSMUSP00000073875; -.
BindingDB; Q9R1W5; -.
ChEMBL; CHEMBL2034811; -.
GuidetoPHARMACOLOGY; 47; -.
iPTMnet; Q9R1W5; -.
PhosphoSitePlus; Q9R1W5; -.
MaxQB; Q9R1W5; -.
PaxDb; Q9R1W5; -.
PRIDE; Q9R1W5; -.
Ensembl; ENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
Ensembl; ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
GeneID; 54598; -.
KEGG; mmu:54598; -.
UCSC; uc008kii.3; mouse.
CTD; 10203; -.
MGI; MGI:1926944; Calcrl.
eggNOG; KOG4564; Eukaryota.
eggNOG; ENOG410XRS2; LUCA.
GeneTree; ENSGT00900000140884; -.
HOGENOM; HOG000230695; -.
HOVERGEN; HBG102129; -.
InParanoid; Q9R1W5; -.
KO; K04577; -.
OMA; HCPDYFQ; -.
OrthoDB; EOG091G027C; -.
PhylomeDB; Q9R1W5; -.
TreeFam; TF315710; -.
Reactome; R-MMU-418555; G alpha (s) signalling events.
Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
PRO; PR:Q9R1W5; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000059588; -.
CleanEx; MM_CALCRL; -.
ExpressionAtlas; Q9R1W5; baseline and differential.
Genevisible; Q9R1W5; MM.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0005768; C:endosome; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005764; C:lysosome; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0001605; F:adrenomedullin receptor activity; ISO:MGI.
GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; IGI:MGI.
GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro.
GO; GO:0008565; F:protein transporter activity; ISO:MGI.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IMP:MGI.
GO; GO:0001525; P:angiogenesis; ISO:MGI.
GO; GO:0006816; P:calcium ion transport; ISO:MGI.
GO; GO:0006171; P:cAMP biosynthetic process; ISO:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0071329; P:cellular response to sucrose stimulus; ISO:MGI.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:MGI.
GO; GO:0015031; P:protein transport; ISO:MGI.
GO; GO:0031623; P:receptor internalization; ISO:MGI.
CDD; cd15274; 7tmB1_calcitonin_R; 1.
Gene3D; 4.10.1240.10; -; 1.
InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
InterPro; IPR036445; GPCR_2_extracell_dom_sf.
InterPro; IPR001879; GPCR_2_extracellular_dom.
InterPro; IPR000832; GPCR_2_secretin-like.
InterPro; IPR017983; GPCR_2_secretin-like_CS.
Pfam; PF00002; 7tm_2; 1.
Pfam; PF02793; HRM; 1.
PRINTS; PR01351; CGRPRECEPTOR.
PRINTS; PR01350; CTRFAMILY.
PRINTS; PR00249; GPCRSECRETIN.
SMART; SM00008; HormR; 1.
SUPFAM; SSF111418; SSF111418; 1.
PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
Receptor; Reference proteome; Signal; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 463 Calcitonin gene-related peptide type 1
receptor.
/FTId=PRO_0000012812.
TOPO_DOM 23 145 Extracellular. {ECO:0000255}.
TRANSMEM 146 165 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 166 172 Cytoplasmic. {ECO:0000255}.
TRANSMEM 173 192 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 193 212 Extracellular. {ECO:0000255}.
TRANSMEM 213 235 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 236 252 Cytoplasmic. {ECO:0000255}.
TRANSMEM 253 272 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 273 288 Extracellular. {ECO:0000255}.
TRANSMEM 289 312 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 313 335 Cytoplasmic. {ECO:0000255}.
TRANSMEM 336 353 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 354 365 Extracellular. {ECO:0000255}.
TRANSMEM 366 387 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 388 463 Cytoplasmic. {ECO:0000255}.
MOD_RES 419 419 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 444 444 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 65 65 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 117 117 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 122 122 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 127 127 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 128 128 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 47 73 {ECO:0000250}.
DISULFID 64 104 {ECO:0000250}.
DISULFID 87 126 {ECO:0000250}.
CONFLICT 235 235 Y -> C (in Ref. 1; BAA76492).
{ECO:0000305}.
CONFLICT 458 458 M -> T (in Ref. 2; AAD35021).
{ECO:0000305}.
SEQUENCE 463 AA; 53265 MW; 630EC8956A4FB47E CRC64;
MDKKHILCFL VLLPLNMALI SAESEEGVNQ TDLGVTRNKI MTAQYECYQK IMQDPIQQAE
GLYCNRTWDG WLCWNDVAAG TESMQYCPDY FQDFDPSEKV TKICDQDGHW FRHPDSNRTW
TNYTLCNNST HEKVKTALNL FYLTIIGHGL SIASLIISLI IFFYFKSLSC QRITLHKNLF
FSFICNSIVT IIHLTAVANN QALVATNPVS CKVSQFIHLY LMGCNYFWML CEGVYLHTLI
VVAVFAEKQH LMWYYFLGWG FPLLPACIHA IARSLYYNDN CWISSDTHLL YIIHGPICAA
LLVNLFFLLN IVRVLITKLK VTHQVESNLY MKAVRATLIL VPLLGIEFVL FPWRPEGKVA
EEVYDYVMHI LMHFQGLLVA TIFCFFNGEV QAILRRNWNQ YKIQFGNGFS HSDALRSASY
TVSTISDMQG YSHDCPTEHL NGKSIQDIEN VALKSENMYD LVM


Related products :

Catalog number Product name Quantity
EIAAB05224 Calcitonin gene-related peptide type 1 receptor,Calcitonin receptor-like receptor,CALCRL,CGRP type 1 receptor,CGRPR,Homo sapiens,Human
EIAAB05221 Calcitonin gene-related peptide type 1 receptor,Calcitonin receptor-like receptor,Calcrl,CGRP type 1 receptor,Crlr,Mouse,Mus musculus
EIAAB05222 Calcitonin gene-related peptide type 1 receptor,Calcitonin receptor-like receptor,Calcrl,CGRP type 1 receptor,Cgrpr,Rat,Rattus norvegicus
EIAAB05220 Bos taurus,Bovine,Calcitonin gene-related peptide type 1 receptor,Calcitonin receptor-like receptor,CALCRL,CGRP type 1 receptor,CGRPR
EIAAB05223 Calcitonin gene-related peptide type 1 receptor,Calcitonin receptor-like receptor,CALCRL,CGRP type 1 receptor,CGRPR,Pig,Sus scrofa
18-461-10603 Calcitonin gene-related peptide type 1 receptor - CGRP type 1 receptor; Calcitonin receptor-like receptor Polyclonal 0.05 ml
18-461-10601 Calcitonin gene-related peptide type 1 receptor - CGRP type 1 receptor; Calcitonin receptor-like receptor Polyclonal 0.05 ml
25-752 CALCRL is the receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G prote 0.05 mg
10-288-22138F Calcitonin gene-related peptide-receptor component protein - CGRP-receptor component protein; CGRP-RCP; CGRPRCP 0.05 mg
10-288-22138F Calcitonin gene-related peptide-receptor component protein - CGRP-receptor component protein; CGRP-RCP; CGRPRCP 0.1 mg
E0472m ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
E0472r ELISA kit Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472r ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
E0472m ELISA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
U0472r CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Rat,Rattus norvegicus 96T
U0472m CLIA Alpha-type CGRP,Calc,Calca,Calcitonin gene-related peptide 1,Calcitonin gene-related peptide I,CGRP-I,Mouse,Mus musculus 96T
EIAAB35834 Calcitonin gene-related peptide-receptor component protein,CGRPRCP,CGRP-RCP,CGRP-receptor component protein,Crcp,DNA-directed RNA polymerase III subunit RPC9,Rat,Rattus norvegicus,RNA polymerase III s
EIAAB35835 Calcitonin gene-related peptide-receptor component protein,CGRPRCP,CGRP-RCP,CGRP-receptor component protein,Crcp,DNA-directed RNA polymerase III subunit RPC9,Mouse,Mus musculus,RNA polymerase III subu
EIAAB35836 Calcitonin gene-related peptide-receptor component protein,CGRPRCP,CGRP-RCP,CGRP-receptor component protein,CRCP,DNA-directed RNA polymerase III subunit RPC9,Homo sapiens,HsC17,Human,RNA polymerase II
E0876h ELISA kit Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
U0876h CLIA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876h ELISA Beta-CGRP,Beta-type CGRP,CALC2,CALCB,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Homo sapiens,Human 96T
E0876m ELISA kit Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Mouse,Mus musculus 96T
E0876r ELISA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T
U0876r CLIA Beta-type CGRP,Calcb,Calcitonin gene-related peptide 2,Calcitonin gene-related peptide II,CGRP-II,Rat,Rattus norvegicus 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur