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Calcium/calmodulin-dependent protein kinase type II delta 1 chain (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase type II delta-B chain) (CaM kinase II subunit delta-B) (CaM-kinase II delta-B chain) (CaMK-II subunit delta-B)

 KC2D1_DANRE             Reviewed;         491 AA.
Q6DEH3; A8KBP0;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
14-OCT-2008, sequence version 2.
10-MAY-2017, entry version 115.
RecName: Full=Calcium/calmodulin-dependent protein kinase type II delta 1 chain {ECO:0000303|PubMed:17103413};
EC=2.7.11.17;
AltName: Full=Calcium/calmodulin-dependent protein kinase type II delta-B chain;
Short=CaM kinase II subunit delta-B;
Short=CaM-kinase II delta-B chain;
Short=CaMK-II subunit delta-B;
Name=camk2d1 {ECO:0000303|PubMed:17103413};
Synonyms=camk2db {ECO:0000312|EMBL:AAH77143.1};
ORFNames=zgc:101001, zgc:173815;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1] {ECO:0000305, ECO:0000312|EMBL:AAH77143.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS E AND G).
TISSUE=Embryo {ECO:0000312|EMBL:AAH77143.1}, and
Olfactory epithelium {ECO:0000312|EMBL:AAI54190.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA] OF 301-383 (ISOFORMS E AND G), ALTERNATIVE
SPLICING, AND TISSUE SPECIFICITY.
PubMed=17103413; DOI=10.1002/dvdy.21005;
Rothschild S.C., Lister J.A., Tombes R.M.;
"Differential expression of CaMK-II genes during early zebrafish
embryogenesis.";
Dev. Dyn. 236:295-305(2007).
-!- FUNCTION: CaM-kinase II (CAMK2) is a prominent kinase in the
central nervous system. {ECO:0000250|UniProtKB:Q13557}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000305}.
-!- ENZYME REGULATION: Autophosphorylation of CAMK2 plays an important
role in the regulation of the kinase activity.
{ECO:0000250|UniProtKB:Q13557}.
-!- SUBUNIT: CAMK2 is composed of four different chains: alpha, beta,
gamma, and delta. The different isoforms assemble into homo- or
heteromultimeric holoenzymes composed of 8 to 12 subunits (By
similarity). {ECO:0000250|UniProtKB:Q13557}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=E {ECO:0000269|PubMed:17103413};
IsoId=Q6DEH3-1; Sequence=Displayed;
Name=G {ECO:0000269|PubMed:17103413};
IsoId=Q6DEH3-2; Sequence=VSP_035558;
-!- TISSUE SPECIFICITY: First detected at the 18-somite stage where
expression is restricted to somite boundaries. At 24 hpf,
expression is elevated in epidermal tissue and in the hatching
gland. After 24 hpf, expression dimishes, but persists at low
levels along the dorsal trunk. At 48 hpf, expression is restricted
at a low level to the forebrain. At 72 hpf, weak expression
reappears along the entire dorsal trunk in discrete cell bodies.
{ECO:0000269|PubMed:17103413}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
Ser/Thr protein kinase family. CaMK subfamily. {ECO:0000255}.
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EMBL; BC077143; AAH77143.1; -; mRNA.
EMBL; BC154189; AAI54190.1; -; mRNA.
RefSeq; NP_001003602.1; NM_001003602.2. [Q6DEH3-2]
RefSeq; NP_001108180.1; NM_001114708.2. [Q6DEH3-1]
UniGene; Dr.78101; -.
ProteinModelPortal; Q6DEH3; -.
SMR; Q6DEH3; -.
STRING; 7955.ENSDARP00000056465; -.
PaxDb; Q6DEH3; -.
PRIDE; Q6DEH3; -.
Ensembl; ENSDART00000056466; ENSDARP00000056465; ENSDARG00000043010. [Q6DEH3-1]
Ensembl; ENSDART00000142259; ENSDARP00000119349; ENSDARG00000043010. [Q6DEH3-2]
GeneID; 445208; -.
KEGG; dre:445208; -.
CTD; 445208; -.
ZFIN; ZDB-GENE-040801-121; camk2d1.
eggNOG; KOG0033; Eukaryota.
eggNOG; ENOG410XNRX; LUCA.
GeneTree; ENSGT00760000118944; -.
HOGENOM; HOG000233016; -.
HOVERGEN; HBG108055; -.
InParanoid; Q6DEH3; -.
KO; K04515; -.
PhylomeDB; Q6DEH3; -.
TreeFam; TF315229; -.
Reactome; R-DRE-3371571; HSF1-dependent transactivation.
Reactome; R-DRE-438066; Unblocking of NMDA receptor, glutamate binding and activation.
Reactome; R-DRE-442729; CREB phosphorylation through the activation of CaMKII.
Reactome; R-DRE-442742; CREB phosphorylation through the activation of Ras.
Reactome; R-DRE-442982; Ras activation uopn Ca2+ infux through NMDA receptor.
Reactome; R-DRE-5576892; Phase 0 - rapid depolarisation.
Reactome; R-DRE-5578775; Ion homeostasis.
Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
Reactome; R-DRE-936837; Ion transport by P-type ATPases.
PRO; PR:Q6DEH3; -.
Proteomes; UP000000437; Chromosome 7.
Bgee; ENSDARG00000043010; -.
ExpressionAtlas; Q6DEH3; baseline.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0043005; C:neuron projection; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0007399; P:nervous system development; IBA:GO_Central.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IBA:GO_Central.
InterPro; IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
InterPro; IPR013543; Ca/CaM-dep_prot_kinase-assoc.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR032710; NTF2-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24347; PTHR24347; 1.
Pfam; PF08332; CaMKII_AD; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF54427; SSF54427; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Calmodulin-binding;
Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1 491 Calcium/calmodulin-dependent protein
kinase type II delta 1 chain.
/FTId=PRO_0000296340.
DOMAIN 13 271 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 19 27 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 135 135 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 42 42 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 286 286 Phosphothreonine.
{ECO:0000250|UniProtKB:Q6PHZ2}.
MOD_RES 314 314 Phosphoserine.
{ECO:0000250|UniProtKB:Q13557}.
MOD_RES 350 350 Phosphothreonine.
{ECO:0000250|UniProtKB:Q6PHZ2}.
VAR_SEQ 326 340 Missing (in isoform G).
{ECO:0000303|PubMed:17103413,
ECO:0000303|Ref.1}.
/FTId=VSP_035558.
SEQUENCE 491 AA; 55829 MW; ADCFD717E279AF15 CRC64;
MASTTCTRFT DEYQLYEELG KGAFSVVRRC MKISTGQEYA AKIINTKKLS ARDHQKLERE
ARICRLLKHA NIVRLHDSIS EEGVHYLVFD LVTGGELFED IVAREYYSEA DASHCIQQIL
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVQGDQQAW FGFAGTPGYL
SPEVLRKEPY GKPVDMWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV
TPEAKDLINK MLTINPAKRI TAAEALKHPW ICQRSTVASM MHRQETVECL KKFNARRKLK
GAILTTMLAT RNFSSKNPYK KPDGVKEPQT TVIHNPTDGN KESSESTNTT IEDEDIKARK
QEIIKVTELL IEAINNGEFE AYTKICDPGL TSFEPEALGN LVEGTDFHRF YFENSLSKGH
KPIHTILLNP HVHLIGEDAA CIAYIRLTQY MDVNNMPRTM QSEETRVWHR RDGKWQNIHF
HRSGSPTVPT K


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