Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)

 KCC2A_PONAB             Reviewed;         478 AA.
Q5RCC4;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
21-JUN-2005, sequence version 2.
25-OCT-2017, entry version 96.
RecName: Full=Calcium/calmodulin-dependent protein kinase type II subunit alpha;
Short=CaM kinase II subunit alpha;
Short=CaMK-II subunit alpha;
EC=2.7.11.17 {ECO:0000250|UniProtKB:Q9UQM7};
Name=CAMK2A;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
TISSUE=Brain cortex;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: CaM-kinase II (CAMK2) is a prominent kinase in the
central nervous system that may function in long-term potentiation
and neurotransmitter release. Member of the NMDAR signaling
complex in excitatory synapses it may regulate NMDAR-dependent
potentiation of the AMPAR and synaptic plasticity. Phosphorylates
transcription factor FOXO3 on 'Ser-298'. Activates FOXO3
transcriptional activity. {ECO:0000250|UniProtKB:P11275,
ECO:0000250|UniProtKB:P11798, ECO:0000250|UniProtKB:Q9UQM7}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000250|UniProtKB:Q9UQM7}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000250|UniProtKB:Q9UQM7};
-!- ENZYME REGULATION: Autophosphorylation of Thr-286 allows the
kinase to switch from a calmodulin-dependent to a calmodulin-
independent state. {ECO:0000250}.
-!- SUBUNIT: CAMK2 is composed of four different chains: alpha, beta,
gamma, and delta. The different isoforms assemble into homo- or
heteromultimeric holoenzymes composed of 8 to 12 subunits.
Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1. Interacts
with SYNPO2 (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P11275}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell
membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}.
Note=Postsynaptic lipid rafts. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=A;
IsoId=Q5RCC4-1; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=B;
IsoId=Q5RCC4-2; Sequence=VSP_014224;
-!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
Ser/Thr protein kinase family. CaMK subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; CR858350; CAH90583.1; -; mRNA.
RefSeq; NP_001125313.1; NM_001131841.1. [Q5RCC4-2]
UniGene; Pab.3372; -.
ProteinModelPortal; Q5RCC4; -.
SMR; Q5RCC4; -.
STRING; 9601.ENSPPYP00000017843; -.
GeneID; 100172212; -.
KEGG; pon:100172212; -.
CTD; 815; -.
eggNOG; KOG0033; Eukaryota.
eggNOG; ENOG410XNRX; LUCA.
HOVERGEN; HBG108055; -.
InParanoid; Q5RCC4; -.
KO; K04515; -.
OrthoDB; EOG091G0SCS; -.
Proteomes; UP000001595; Unplaced.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
InterPro; IPR013543; Ca/CaM-dep_prot_kinase-assoc.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR032710; NTF2-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF08332; CaMKII_AD; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF54427; SSF54427; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Calmodulin-binding; Cell junction;
Cell membrane; Complete proteome; Kinase; Magnesium; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Synapse; Transferase.
CHAIN 1 478 Calcium/calmodulin-dependent protein
kinase type II subunit alpha.
/FTId=PRO_0000086093.
DOMAIN 13 271 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 19 27 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 290 300 Calmodulin-binding.
REGION 310 320 Interaction with BAALC. {ECO:0000250}.
ACT_SITE 135 135 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 42 42 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 13 13 Phosphotyrosine.
{ECO:0000250|UniProtKB:P11798}.
MOD_RES 257 257 Phosphoserine.
{ECO:0000250|UniProtKB:P11275}.
MOD_RES 286 286 Phosphothreonine; by autocatalysis.
{ECO:0000250|UniProtKB:P11275}.
MOD_RES 330 330 Phosphoserine.
{ECO:0000250|UniProtKB:P11798}.
MOD_RES 331 331 Phosphoserine.
{ECO:0000250|UniProtKB:P11798}.
MOD_RES 333 333 Phosphoserine.
{ECO:0000250|UniProtKB:P11798}.
MOD_RES 336 336 Phosphothreonine.
{ECO:0000250|UniProtKB:P11798}.
MOD_RES 337 337 Phosphothreonine.
{ECO:0000250|UniProtKB:P11798}.
MOD_RES 404 404 Phosphoserine.
{ECO:0000250|UniProtKB:P11798}.
VAR_SEQ 328 328 K -> KKRKSSSSVQLM (in isoform B).
{ECO:0000303|Ref.1}.
/FTId=VSP_014224.
SEQUENCE 478 AA; 54088 MW; 208143A311BA9262 CRC64;
MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA
ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH


Related products :

Catalog number Product name Quantity
E0655h ELISA Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,CAMK2A,CAMKA,CaMK-II subunit alpha,Homo sapiens,Human,KIAA0968 96T
E0655h ELISA kit Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,CAMK2A,CAMKA,CaMK-II subunit alpha,Homo sapiens,Human,KIAA0968 96T
U0655h CLIA Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,CAMK2A,CAMKA,CaMK-II subunit alpha,Homo sapiens,Human,KIAA0968 96T
E0655r ELISA Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,Camk2a,CaMK-II subunit alpha,Rat,Rattus norvegicus 96T
E0655m ELISA kit Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,Camk2a,CaMK-II subunit alpha,Mouse,Mus musculus 96T
E0655r ELISA kit Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,Camk2a,CaMK-II subunit alpha,Rat,Rattus norvegicus 96T
U0655m CLIA Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,Camk2a,CaMK-II subunit alpha,Mouse,Mus musculus 96T
E0655m ELISA Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,Camk2a,CaMK-II subunit alpha,Mouse,Mus musculus 96T
U0655r CLIA Calcium_calmodulin-dependent protein kinase type II subunit alpha,CaM kinase II subunit alpha,Camk2a,CaMK-II subunit alpha,Rat,Rattus norvegicus 96T
17-662-20008 Calcium_calmodulin-dependent protein kinase type II alpha chain - EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha Serum 0.1 ml
18-662-20052 Calcium_calmodulin-dependent protein kinase type II alpha chain - EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha Polyclonal 0.1 ml
18-783-75638 RABBIT ANTI CaMKII - CALCIUM_CALMODULIN-DEPENDENT KINASE II; EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha Polyclonal 0.05 mg
CSB-EL004465MO Mouse Calcium per calmodulin-dependent protein kinase type II subunit alpha(CAMK2A) ELISA kit 96T
18-785-210060 CaMKII (Phospho-Thr286) - EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha Polyclonal 0.05 mg
18-785-210060 CaMKII (Phospho-Thr286) - EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha Polyclonal 0.1 mg
E0655m ELISA Kit FOR Calcium per calmodulin-dependent protein kinase type II subunit alpha; organism: Mouse; gene name: Camk2a 96T
E0655h ELISA Kit FOR Calcium per calmodulin-dependent protein kinase type II subunit alpha; organism: Human; gene name: CAMK2A 96T
18-785-210061 CaMKII (Ab-286) - EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha Polyclonal 0.05 mg
18-785-210061 CaMKII (Ab-286) - EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha Polyclonal 0.1 mg
EIAAB29519 Homo sapiens,Human,Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphoinositide 3-kinase-C2-alpha,PI3K-C2-alpha,PIK3C2A,PtdIns-3-kinase C2 subunit alpha
EIAAB29518 Cpk,Cpk-m,Mouse,Mus musculus,p170,Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphoinositide 3-kinase-C2-alpha,PI3K-C2-alpha,Pik3c2a,PtdIns-3-kinase C2 subunit alpha
EIAAB31922 Calmodulin-dependent calcineurin A subunit alpha isoform,CALNA,CAM-PRP catalytic subunit,CNA,Homo sapiens,Human,PPP3CA,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB31921 Calmodulin-dependent calcineurin A subunit alpha isoform,Calna,CAM-PRP catalytic subunit,Ppp3ca,Rat,Rattus norvegicus,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB31920 Calmodulin-dependent calcineurin A subunit alpha isoform,Calna,CAM-PRP catalytic subunit,Mouse,Mus musculus,Ppp3ca,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB31919 Bos taurus,Bovine,Calmodulin-dependent calcineurin A subunit alpha isoform,CAM-PRP catalytic subunit,PPP3CA,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur