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Calcium and integrin-binding family member 2 (Fragment)

 CIB2_SHEEP              Reviewed;         176 AA.
C7A276;
19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
22-SEP-2009, sequence version 1.
10-MAY-2017, entry version 27.
RecName: Full=Calcium and integrin-binding family member 2;
Flags: Fragment;
Name=CIB2;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=18989754; DOI=10.1007/s11033-008-9383-4;
Yu Y., Song X., Du L., Wang C.;
"Molecular characterization of the sheep CIB1 gene.";
Mol. Biol. Rep. 36:1799-1809(2009).
-!- FUNCTION: Calcium-binding protein critical for proper
photoreceptor cell maintenance and function. Plays a role in
intracellular calcium homeostasis by decreasing ATP-induced
calcium release. May be involved in the mechanotransduction
process. {ECO:0000250, ECO:0000250|UniProtKB:O75838}.
-!- SUBUNIT: Homodimer. Interacts with WHRN and MYO7A. Interacts with
ITGA2B (via C-terminus cytoplasmic tail region) and ITGA7 (via C-
terminus cytoplasmic tail region); the interactions are
stabilized/increased in a calcium and magnesium-dependent manner.
{ECO:0000250|UniProtKB:O75838}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z309}.
Cell projection, stereocilium {ECO:0000250|UniProtKB:O75838}.
Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9Z309}. Cell
projection, cilium, photoreceptor outer segment
{ECO:0000250|UniProtKB:Q9Z309}. Cell membrane, sarcolemma
{ECO:0000250|UniProtKB:Q9Z309}. Note=Colocalized with ITGA7 at the
myotendinous junctions (MTJ) and at the neuromuscular junctions
(NMJ). Localizes in the cuticular plate along and at the tip of
the stereocilia of vestibular sensory hair cells.
{ECO:0000250|UniProtKB:O75838, ECO:0000250|UniProtKB:Q9Z309}.
-!- TISSUE SPECIFICITY: Expressed in liver, heart, kidney, brain,
spleen, stomach, ovary, testis and muscle (PubMed:18989754).
{ECO:0000269|PubMed:18989754}.
-!- MISCELLANEOUS: The binding of either calcium or magnesium
significantly increases the structural stability of the protein in
comparison to apo-CIB (calcium- and magnesium-free form).
{ECO:0000250|UniProtKB:O75838}.
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EMBL; FJ039530; ACM89972.1; -; mRNA.
UniGene; Oar.17800; -.
SMR; C7A276; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0032437; C:cuticular plate; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
GO; GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO; GO:0032420; C:stereocilium; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0071318; P:cellular response to ATP; ISS:UniProtKB.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
CDD; cd00051; EFh; 1.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13499; EF-hand_7; 1.
SMART; SM00054; EFh; 3.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 2.
PROSITE; PS50222; EF_HAND_2; 3.
2: Evidence at transcript level;
Calcium; Cell membrane; Cell projection; Complete proteome; Cytoplasm;
Magnesium; Membrane; Metal-binding; Reference proteome; Repeat.
CHAIN <1 176 Calcium and integrin-binding family
member 2.
/FTId=PRO_0000425744.
DOMAIN 55 90 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 92 127 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 133 168 EF-hand 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 105 116 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 146 157 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
NON_TER 1 1
SEQUENCE 176 AA; 20459 MW; 47269994F2D04189 CRC64;
LFYRYQDCTF FNKKDILKLH ARFYELAPNL VPMDYRKSPI VHVPMSLIIQ MPELRENPFK
ERIVEAFSED GEGNLTFNDF VDMFSVLCES APRDLKASYA FKIYDFNTDN FICKEDLQLT
LARLTKSELD EDEVVLVCDK VIEEADLDGD GKLGFADFED MIAKAPDFLS TFHIRI


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