Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Calcium and integrin-binding protein 1 (Calmyrin)

 CIB1_SHEEP              Reviewed;         191 AA.
B1A8Z2;
19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
08-APR-2008, sequence version 1.
30-AUG-2017, entry version 55.
RecName: Full=Calcium and integrin-binding protein 1;
AltName: Full=Calmyrin;
Name=CIB1;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=18989754; DOI=10.1007/s11033-008-9383-4;
Yu Y., Song X., Du L., Wang C.;
"Molecular characterization of the sheep CIB1 gene.";
Mol. Biol. Rep. 36:1799-1809(2009).
-!- FUNCTION: Calcium-binding protein that plays a role in the
regulation of numerous cellular processes, such as cell
differentiation, cell division, cell proliferation, cell
migration, thrombosis, angiogenesis, cardiac hypertrophy and
apoptosis. Involved in bone marrow megakaryocyte differentiation
by negatively regulating thrombopoietin-mediated signaling
pathway. Participates in the endomitotic cell cycle of
megakaryocyte, a form of mitosis in which both karyokinesis and
cytokinesis are interrupted. Plays a role in integrin signaling by
negatively regulating alpha-IIb/beta3 activation in thrombin-
stimulated megakaryocytes preventing platelet aggregation. Up-
regulates PTK2/FAK1 activity, and is also needed for the
recruitment of PTK2/FAK1 to focal adhesions; it thus appears to
play an important role in focal adhesion formation. Positively
regulates cell migration on fibronectin in a CDC42-dependent
manner, the effect being negatively regulated by PAK1. Functions
as a negative regulator of stress activated MAP kinase (MAPK)
signaling pathways. Down-regulates inositol 1,4,5-trisphosphate
receptor-dependent calcium signaling. Involved in sphingosine
kinase SPHK1 translocation to the plasma membrane in a N-
myristoylation-dependent manner preventing TNF-alpha-induced
apoptosis. Regulates serine/threonine-protein kinase PLK3 activity
for proper completion of cell division progression. Plays a role
in microtubule (MT) dynamics during neuronal development; disrupts
the MT depolymerization activity of STMN2 attenuating NGF-induced
neurite outgrowth and the MT reorganization at the edge of
lamellipodia. Promotes cardiomyocyte hypertrophy via activation of
the calcineurin/NFAT signaling pathway. Stimulates calcineurin
PPP3R1 activity by mediating its anchoring to the sarcolemma. In
ischemia-induced (pathological or adaptive) angiogenesis,
stimulates endothelial cell proliferation, migration and
microvessel formation by activating the PAK1 and ERK1/ERK2
signaling pathway. Promotes also cancer cell survival and
proliferation. May regulate cell cycle and differentiation of
spermatogenic germ cells, and/or differentiation of supporting
Sertoli cells (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer. Interacts with the heterodimeric integrin alpha-
IIb/beta3 (ITGA2B-ITGB3). Interacts with ITGA2B (via cytoplasmic
domain); the interaction is direct and calcium-dependent.
Interacts with the protein kinases PLK2/SNK and PRKDC (via the
region immediately upstream of the kinase domain). Interacts with
PLK3; the interaction inhibits PLK3 kinase activity. Interacts
with PSEN2. Interacts (via C-terminus) with F8. Interacts with
NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus).
Interacts with UBR5 (via C-terminus); the interaction is sensitive
to DNA damage, and may target CIB1 for ubiquitin-mediated
degradation. Interacts with IFI6. Interacts with BCL2. Interacts
with ITPR3; the interaction occurs in a calcium dependent manner.
Interacts with PTK2/FAK1. Interacts with MAP3K5; the interaction
inhibits MAP3K5 activation by phosphorylation, and its subsequent
interaction with TRAF2. Interacts (via C-terminal region) with
STMN2 (via the N-terminal region); the interaction is direct,
occurs in a calcium-dependent manner and attenuates the STMN2-
induced neurite outgrowth inhibition. Interacts with SPHK1, the
interaction occurs in a calcium-dependent manner. Interacts with
ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs
upon platelet aggregation and is stabilized/increased in a calcium
and magnesium-dependent manner. Interacts with PAK1 (via N-
terminal region); the interaction is direct and occurs in a
calcium-dependent manner. Interacts with RAC3 (via C-terminal
region); the interaction induces their association with the
cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.
Interacts with ITGA5 and ITGAV. Interacts with MYO1C. Interacts
with ITGA2B (via C-terminal cytoplasmic tail region). Interacts
(via C-terminal region) with PPP3R1; the interaction increases
upon cardiomyocytes hypertrophy. Interacts with CACNA1C; the
interaction increases upon cardiomyocytes hypertrophy. Interacts
with TAS1R2 (via C-terminus); this interaction is independent of
the myristoylation state of CIB1 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor
{ECO:0000250}. Cell membrane {ECO:0000250}. Cell membrane,
sarcolemma {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm,
cytoskeleton, microtubule organizing center, centrosome
{ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear
region {ECO:0000250}. Cell projection, filopodium tip
{ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell
projection, ruffle membrane {ECO:0000250}. Cell projection, growth
cone {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalized with NBR1
to the perinuclear region. Colocalized with RAC3 in the
perinuclear area and at the cell periphery. Colocalized with PAK1
within membrane ruffles during cell spreading upon readhesion to
fibronectin. Redistributed to the cytoskeleton upon platelet
aggregation. Translocates from the cytosol to the plasma membrane
in a calcium-dependent manner. Colocalized with STMN2 to the
leading edge of lamellipodia. Colocalizes with PLK3 at the
centrosomes in ductal breast carcinoma cells. Colocalized with
PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic
heart. Colocalized with STMN2 in the cell body, neurites and
growth cones of neurons. Colocalizes with TAS1R2 in apical regions
of taste receptor cells (By similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed strongly in testis. Expressed weakly
in liver, kidney and spleen. {ECO:0000269|PubMed:18989754}.
-!- DOMAIN: The EF-hands may also bind magnesium ions in the presence
of high Mg(2+) levels and low Ca(2+) levels. {ECO:0000250}.
-!- MISCELLANEOUS: The binding of either calcium or magnesium
significantly increases the structural stability of the protein in
comparison to apo-CIB (calcium- and magnesium-free form).
{ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; EU430744; ABZ91971.1; -; mRNA.
EMBL; EU499336; ACD39827.1; -; Genomic_DNA.
RefSeq; NP_001108237.1; NM_001114765.1.
UniGene; Oar.4014; -.
ProteinModelPortal; B1A8Z2; -.
SMR; B1A8Z2; -.
Ensembl; ENSOART00000013190; ENSOARP00000013001; ENSOARG00000012128.
GeneID; 100141300; -.
KEGG; oas:100141300; -.
CTD; 10519; -.
GeneTree; ENSGT00860000133737; -.
HOVERGEN; HBG107344; -.
KO; K17259; -.
Proteomes; UP000002356; Chromosome 18.
ExpressionAtlas; B1A8Z2; baseline.
GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
CDD; cd00051; EFh; 1.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13499; EF-hand_7; 1.
SMART; SM00054; EFh; 2.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 2.
PROSITE; PS50222; EF_HAND_2; 2.
2: Evidence at transcript level;
Angiogenesis; Apoptosis; Calcium; Cell adhesion; Cell cycle;
Cell division; Cell membrane; Cell projection; Complete proteome;
Cytoplasm; Cytoskeleton; Differentiation; Integrin; Lipoprotein;
Magnesium; Membrane; Myristate; Nucleus; Reference proteome; Repeat;
Spermatogenesis.
INIT_MET 1 1 Removed. {ECO:0000255}.
CHAIN 2 191 Calcium and integrin-binding protein 1.
/FTId=PRO_0000425743.
DOMAIN 103 138 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 148 183 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 116 127 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 161 172 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
LIPID 2 2 N-myristoyl glycine. {ECO:0000255}.
SEQUENCE 191 AA; 21728 MW; C6E0C5FC56F6E589 CRC64;
MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EHRSVEESLQ ARVSLEQILS
LPELKANPFK ERICKVFSTS PSRDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD
GTLNREDLSQ LVNCLTGESE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS
PDFASSFKIV L


Related products :

Catalog number Product name Quantity
U1394h CLIA Calcium- and integrin-binding protein,Calcium and integrin-binding protein 1,Calmyrin,CIB,CIB,CIB1,CIBP,DNA-PKcs-interacting protein,Homo sapiens,Human,Kinase-interacting protein,KIP,KIP,PRKDCIP, 96T
E1394h ELISA Calcium- and integrin-binding protein,Calcium and integrin-binding protein 1,Calmyrin,CIB,CIB,CIB1,CIBP,DNA-PKcs-interacting protein,Homo sapiens,Human,Kinase-interacting protein,KIP,KIP,PRKDCIP 96T
E1394h ELISA kit Calcium- and integrin-binding protein,Calcium and integrin-binding protein 1,Calmyrin,CIB,CIB,CIB1,CIBP,DNA-PKcs-interacting protein,Homo sapiens,Human,Kinase-interacting protein,KIP,KIP,PR 96T
32-136 CIB1(also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent pr 0.1 mL
E1394b ELISA Bos taurus,Bovine,Calcium and integrin-binding protein 1,Calmyrin,CIB1 96T
U1394b CLIA Bos taurus,Bovine,Calcium and integrin-binding protein 1,Calmyrin,CIB1 96T
E1394b ELISA kit Bos taurus,Bovine,Calcium and integrin-binding protein 1,Calmyrin,CIB1 96T
CIB3 CIB1 Gene calcium and integrin binding 1 (calmyrin)
abx111299 Polyclonal Rabbit Calcium And Integrin Binding 1 (Calmyrin) Antibody 50 μl
E1394r ELISA kit Calcium and integrin-binding protein 1,Calmyrin,CIB,Cib,Cib1,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,Kip,Prkdcip,Rat,Rattus norvegicus 96T
E1394m ELISA kit Calcium and integrin-binding protein 1,Calmyrin,CIB,Cib,Cib1,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,Kip,Mouse,Mus musculus,Prkdcip 96T
U1394m CLIA Calcium and integrin-binding protein 1,Calmyrin,CIB,Cib,Cib1,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,Kip,Mouse,Mus musculus,Prkdcip 96T
E1394r ELISA Calcium and integrin-binding protein 1,Calmyrin,CIB,Cib,Cib1,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,Kip,Prkdcip,Rat,Rattus norvegicus 96T
E1394m ELISA Calcium and integrin-binding protein 1,Calmyrin,CIB,Cib,Cib1,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,Kip,Mouse,Mus musculus,Prkdcip 96T
U1394r CLIA Calcium and integrin-binding protein 1,Calmyrin,CIB,Cib,Cib1,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,Kip,Prkdcip,Rat,Rattus norvegicus 96T
MA-20087 Mouse Monoclonal Anti-Human CIB1 (calcium and integrin binding 1 or calmyrin) 100 ul
CSB-EL005426RA Rat calcium and integrin binding 1 (calmyrin) (CIB1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
10-288-21983F Calcium and integrin-binding protein 1 - Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; CIB; SNK-interacting protein 2-28; SIP2-28 0.1 mg
10-288-21983F Calcium and integrin-binding protein 1 - Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; CIB; SNK-interacting protein 2-28; SIP2-28 0.05 mg
MA-20087 Mouse Monoclonal Anti-Human CIB1 (calcium and integrin binding 1 or calmyrin) Species Reactivity: Human 100 ul Product tipe: Antibodies
CSB-EL005426MO Mouse calcium and integrin binding 1 (calmyrin) (CIB1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL005426BO Bovine calcium and integrin binding 1 (calmyrin) (CIB1) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL005426HU Human calcium and integrin binding 1 (calmyrin) (CIB1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-PA005426GA01HU Rabbit anti-human calcium and integrin binding 1 (calmyrin) polyclonal Antibody Primary antibody Host:Rabbit IgG 50ul
CSB-PA005426GA01HU Rabbit anti-human calcium and integrin binding 1 (calmyrin) polyclonal Antibody Primary antibody Host:Rabbit IgG 150ul


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur