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Calcium homeostasis endoplasmic reticulum protein (SR-related CTD-associated factor 6)

 CHERP_MOUSE             Reviewed;         936 AA.
Q8CGZ0; Q8K291; Q8VCD2;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
25-OCT-2017, entry version 108.
RecName: Full=Calcium homeostasis endoplasmic reticulum protein;
AltName: Full=SR-related CTD-associated factor 6;
Name=Cherp {ECO:0000312|MGI:MGI:106417};
Synonyms=Scaf6 {ECO:0000312|EMBL:AAN77182.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:AAN77182.1}
NUCLEOTIDE SEQUENCE [MRNA].
Sampson N.D., Hewitt J.E.;
"Functional characterization of the novel SR-related CTD associated
factor, SCAF6.";
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-723, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Mast cell;
PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
Kawakami T., Salomon A.R.;
"Quantitative time-resolved phosphoproteomic analysis of mast cell
signaling.";
J. Immunol. 179:5864-5876(2007).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-824; SER-826 AND
THR-828, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-822; SER-824; SER-826
AND THR-828, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Involved in calcium homeostasis, growth and
proliferation. {ECO:0000250|UniProtKB:Q8IWX8}.
-!- INTERACTION:
Q15637:SF1 (xeno); NbExp=3; IntAct=EBI-2366446, EBI-744603;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IWX8}.
Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8IWX8}.
Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IWX8}.
Note=Distributed throughout the cytoplasm and also localizes to
the perinuclear region. Colocalizes with ITPR1 (By similarity).
{ECO:0000250|UniProtKB:Q8IWX8}.
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EMBL; AF536541; AAN77182.1; -; mRNA.
EMBL; BC020488; -; NOT_ANNOTATED_CDS; mRNA.
RefSeq; NP_613051.3; NM_138585.3.
UniGene; Mm.30136; -.
ProteinModelPortal; Q8CGZ0; -.
SMR; Q8CGZ0; -.
BioGrid; 205695; 2.
IntAct; Q8CGZ0; 3.
MINT; MINT-4115833; -.
STRING; 10090.ENSMUSP00000078469; -.
iPTMnet; Q8CGZ0; -.
PhosphoSitePlus; Q8CGZ0; -.
EPD; Q8CGZ0; -.
MaxQB; Q8CGZ0; -.
PaxDb; Q8CGZ0; -.
PRIDE; Q8CGZ0; -.
GeneID; 27967; -.
KEGG; mmu:27967; -.
UCSC; uc009mgb.1; mouse.
CTD; 10523; -.
MGI; MGI:106417; Cherp.
eggNOG; KOG4368; Eukaryota.
eggNOG; ENOG410YVN1; LUCA.
HOGENOM; HOG000010294; -.
HOVERGEN; HBG052716; -.
InParanoid; Q8CGZ0; -.
KO; K12841; -.
PhylomeDB; Q8CGZ0; -.
PRO; PR:Q8CGZ0; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_CHERP; -.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0044325; F:ion channel binding; ISO:MGI.
GO; GO:0003723; F:RNA binding; ISO:MGI.
GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:MGI.
GO; GO:0008285; P:negative regulation of cell proliferation; ISO:MGI.
GO; GO:0051533; P:positive regulation of NFAT protein import into nucleus; ISO:MGI.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:MGI.
GO; GO:0006396; P:RNA processing; IEA:InterPro.
Gene3D; 1.25.40.90; -; 1.
InterPro; IPR006569; CID_dom.
InterPro; IPR008942; ENTH_VHS.
InterPro; IPR000467; G_patch_dom.
InterPro; IPR006903; RNA_pol_II-bd.
InterPro; IPR000061; Surp.
InterPro; IPR035967; SWAP/Surp_sf.
Pfam; PF04818; CTD_bind; 1.
Pfam; PF01585; G-patch; 1.
Pfam; PF01805; Surp; 1.
SMART; SM00443; G_patch; 1.
SMART; SM00648; SWAP; 1.
SUPFAM; SSF109905; SSF109905; 1.
SUPFAM; SSF48464; SSF48464; 1.
PROSITE; PS51391; CID; 1.
PROSITE; PS50174; G_PATCH; 1.
PROSITE; PS50128; SURP; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Cytoplasm; Endoplasmic reticulum;
Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation.
CHAIN 1 936 Calcium homeostasis endoplasmic reticulum
protein.
/FTId=PRO_0000299493.
REPEAT 15 57 SURP motif. {ECO:0000255}.
DOMAIN 149 289 CID. {ECO:0000255|PROSITE-
ProRule:PRU00724}.
DOMAIN 850 900 G-patch. {ECO:0000255|PROSITE-
ProRule:PRU00092}.
COMPBIAS 279 355 Gln-rich. {ECO:0000255}.
COMPBIAS 343 691 Pro-rich. {ECO:0000255}.
COMPBIAS 727 825 Arg-rich. {ECO:0000255}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:Q8IWX8}.
MOD_RES 18 18 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8IWX8}.
MOD_RES 723 723 Phosphotyrosine.
{ECO:0000244|PubMed:17947660}.
MOD_RES 822 822 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 824 824 Phosphoserine.
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 826 826 Phosphoserine.
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 828 828 Phosphothreonine.
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 837 837 Phosphoserine.
{ECO:0000250|UniProtKB:Q8IWX8}.
MOD_RES 864 864 Phosphoserine.
{ECO:0000250|UniProtKB:Q8IWX8}.
MOD_RES 866 866 Phosphoserine.
{ECO:0000250|UniProtKB:Q8IWX8}.
MOD_RES 888 888 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8IWX8}.
MOD_RES 913 913 Phosphoserine.
{ECO:0000250|UniProtKB:Q8IWX8}.
CROSSLNK 853 853 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8IWX8}.
CROSSLNK 881 881 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8IWX8}.
CONFLICT 348 349 Missing (in Ref. 2; BC020488).
{ECO:0000305}.
SEQUENCE 936 AA; 106169 MW; 8C29DF0822CA9EB3 CRC64;
MEMPMPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG EFYSYYKCKL
ALEQQQLICK QQAPELEPTS AMPPLPQPPL APTASLTPAQ GTPSMDELIQ QSQWSLQQQE
QHLLALRQEQ VTTAVAHAVE QQMQKLLEET QLDMSEFDNL LQPIIDTCTK DAISAGKNWM
FSNAKSPPHC ELMAGHLRNR ITADGAHFEL RLHLIYLIND VLHHCQRKQA RELLAALQKV
VVPIYCTSFL AVEEDKQQKI ARLLQLWEKN GYFDDSIIQQ LQSPALGLGQ YQATLINEYS
SVVQPVQLAF QQQIQSLKTQ HEEFVSSLAQ QQQQQQQQQQ QQPQPQPQPQ IQLPQMEADV
KATPPPPAPP PASAPAPTIP PTTQPDDNKP PIQMPGSSEY DTSAGVQDPA AAGPRGPGPH
EQIPPNKPPW FDQPHPVAPW GQQQPPEQPP YPHHQGGPPH CPPWNNSHEG MWGEQRGDPG
WNGQRDAPWN NQPDPNWNNQ FEGPWNNQHE PPPWGGAQRE PPFRMQRPPH FRGPFPPHQQ
HPQFNQPPHP HNFNRFPPRF MQDDFPPRHP FERPPYPHRF DYPQGDFPAD MGPPHHHPGH
RMPHPGINEH PPWAGPQHPD FGPPPHGFNG QPPHMRRQGP PHINHDDPSL VPNVPYFDLP
AGLMAPLVKL EDHEYKPLDP KDIRLPPPMP PSERLLAAVE AFYSPPSHDR PRNSEGWEQN
GLYEFFRAKM RARRRKGQEK RNSGPSRSRS RSKSRGRSSS RSSSRSSKSS RSSSRSHSRS
RSRSSSRSRS RSRSRSRSSR SRSRSRSRSR SKSYSPGRRR RSRSRSPTPP SAAGLGSNSA
PPIPDSRLGE ENKGHQMLVK MGWSGSGGLG AKEQGIQDPI KGGDVRDKWD QYKGVGVALD
DPYENYRRNK SYSFIARMKA RDEFSTFGTR KEEKED


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