GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta)
KCMB1_CANLF Reviewed; 191 AA.
Q28266;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
16-JAN-2019, entry version 92.
RecName: Full=Calcium-activated potassium channel subunit beta-1;
AltName: Full=BK channel subunit beta-1;
Short=BKbeta;
Short=BKbeta1;
AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta-1;
Short=Calcium-activated potassium channel subunit beta;
AltName: Full=Charybdotoxin receptor subunit beta-1;
AltName: Full=K(VCA)beta-1;
AltName: Full=Maxi K channel subunit beta-1;
AltName: Full=Slo-beta-1;
Short=Slo-beta;
Name=KCNMB1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8897882;
Vogalis F., Vincent T., Qureshi I., Schmalz F.M., Ward M.W.,
Sanders K.M., Horowitz B.;
"Cloning and expression of the large-conductance Ca(2+)-activated K+
channel from colonic smooth muscle.";
Am. J. Physiol. 271:G629-G639(1996).
-!- FUNCTION: Regulatory subunit of the calcium activated potassium
KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and
gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel
diversity. Increases the apparent Ca(2+)/voltage sensitivity of
the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and
alters its pharmacological properties. It slows down the
activation and the deactivation kinetics of the channel. Acts as a
negative regulator of smooth muscle contraction by enhancing the
calcium sensitivity to KCNMA1. Its presence is also a requirement
for internal binding of the KCNMA1 channel opener
dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external
binding of the agonist hormone 17-beta-estradiol (E2). Increases
the binding activity of charybdotoxin (CTX) toxin to KCNMA1
peptide blocker by increasing the CTX association rate and
decreasing the dissociation rate (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4
molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
protein {ECO:0000250}.
-!- PTM: N-glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U41002; AAA84001.1; -; mRNA.
RefSeq; NP_001003299.1; NM_001003299.1.
UniGene; Cfa.3852; -.
STRING; 9615.ENSCAFP00000024942; -.
PaxDb; Q28266; -.
GeneID; 403983; -.
KEGG; cfa:403983; -.
CTD; 3779; -.
eggNOG; ENOG410IWME; Eukaryota.
eggNOG; ENOG41116AX; LUCA.
HOGENOM; HOG000290180; -.
HOVERGEN; HBG052223; -.
InParanoid; Q28266; -.
KO; K04937; -.
OrthoDB; 1178937at2759; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
GO; GO:0015269; F:calcium-activated potassium channel activity; IBA:GO_Central.
GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
GO; GO:0005513; P:detection of calcium ion; IBA:GO_Central.
InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
PANTHER; PTHR10258; PTHR10258; 1.
Pfam; PF03185; CaKB; 1.
PRINTS; PR01450; BKCHANNELB.
2: Evidence at transcript level;
Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 191 Calcium-activated potassium channel
subunit beta-1.
/FTId=PRO_0000187045.
TOPO_DOM 1 15 Cytoplasmic. {ECO:0000255}.
TRANSMEM 16 36 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 37 157 Extracellular. {ECO:0000255}.
TRANSMEM 158 178 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 179 191 Cytoplasmic. {ECO:0000255}.
CARBOHYD 80 80 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 142 142 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 191 AA; 21935 MW; 31E115A8FA530875 CRC64;
MGKKLVMAQK RGETRALCLG VAMVMCAVIA YYILGTTMLP LYQKSVWTQK STCHLIETNI
REQEELEGKK VPQYPCLWVN VSAVGRWAVL YHTEDTRDQN HQCSYIPGSL ENYQVARADV
EKVKAKFHEQ QIFYCFSTTR ENETTVLYRR LYGPQTLLFS LFWPTFLLTG GLLIIAMVKI
NQSLSILAAQ R
Related products :
GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur
GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur
GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
RCS Paris B 484 237 888
SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur
GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur
GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel: 0208-080893 Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62 SWIFT RABONL2U
GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur
ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX 058 710 33 48
poland@gentaur.com | Gentaur | Gentaur
Other countries
Österreich +43720880899
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Danmark +4569918806
Finland Helsset +358942419041
Magyarország Budapest +3619980547
Ireland Dublin+35316526556
Luxembourg+35220880274
Norge Oslo+4721031366
Sverige Stockholm+46852503438
Schweiz Züri+41435006251
US New York+17185132983
GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur
Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1045: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP566: canonical wnt - zebrafish
WP809: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2
WP1058: Senescence and Autophagy
WP1061: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP113: TGF Beta Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1177: Fatty Acid Beta Oxidation
WP1207: Fatty Acid Beta Oxidation
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1237: Fatty Acid Beta Oxidation
Related Genes :
Bibliography :
Enter catalog number :
Favorites Pages:
No Favorits