Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta)

 KCMB1_MOUSE             Reviewed;         191 AA.
Q8CAE3; O35336; O35645;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
25-OCT-2017, entry version 98.
RecName: Full=Calcium-activated potassium channel subunit beta-1;
AltName: Full=BK channel subunit beta-1;
Short=BKbeta;
Short=BKbeta1;
AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta-1;
Short=Calcium-activated potassium channel subunit beta;
AltName: Full=Charybdotoxin receptor subunit beta-1;
AltName: Full=K(VCA)beta-1;
AltName: Full=Maxi K channel subunit beta-1;
AltName: Full=Slo-beta-1;
Short=Slo-beta;
Name=Kcnmb1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Intestinal smooth muscle;
PubMed=9888999; DOI=10.1006/geno.1998.5627;
Jiang Z., Wallner M., Meera P., Toro L.;
"Human and rodent MaxiK channel beta-subunit genes: cloning and
characterization.";
Genomics 55:57-67(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ; TISSUE=Heart muscle;
Metzler M.H.F., Repp R., Zibuschka C., Dreyer F., Repp H.;
"Cloning and functional analysis of a calcium activated potassium
channel beta-subunit from murine heart muscle.";
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Hypothalamus;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=11057658; DOI=10.1038/35038011;
Brenner R., Perez G.J., Bonev A.D., Eckman D.M., Kosek J.C.,
Wiler S.W., Patterson A.J., Nelson M.T., Aldrich R.W.;
"Vasoregulation by the beta1 subunit of the calcium-activated
potassium channel.";
Nature 407:870-876(2000).
-!- FUNCTION: Regulatory subunit of the calcium activated potassium
KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and
gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel
diversity. Increases the apparent Ca(2+)/voltage sensitivity of
the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and
alters its pharmacological properties. It slows down the
activation and the deactivation kinetics of the channel. Acts as a
negative regulator of smooth muscle contraction by enhancing the
calcium sensitivity to KCNMA1. Its presence is also a requirement
for internal binding of the KCNMA1 channel opener
dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external
binding of the agonist hormone 17-beta-estradiol (E2). Increases
the binding activity of charybdotoxin (CTX) toxin to KCNMA1
peptide blocker by increasing the CTX association rate and
decreasing the dissociation rate. {ECO:0000269|PubMed:11057658}.
-!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4
molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
{ECO:0000250}.
-!- INTERACTION:
Q08460-4:Kcnma1; NbExp=2; IntAct=EBI-15575793, EBI-15575817;
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in many tissues containing smooth
muscles. In brain and heart, it is not expressed except in the
vasculature, such as cerebral arteries, aorta and corona arteries.
{ECO:0000269|PubMed:11057658}.
-!- PTM: N-glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF020711; AAD11857.1; -; mRNA.
EMBL; AJ001291; CAA04651.1; -; mRNA.
EMBL; AK038987; BAC30193.1; -; mRNA.
EMBL; BC013338; AAH13338.1; -; mRNA.
CCDS; CCDS24538.1; -.
RefSeq; NP_112446.2; NM_031169.4.
RefSeq; XP_006514604.1; XM_006514541.3.
UniGene; Mm.6206; -.
SMR; Q8CAE3; -.
BioGrid; 200915; 1.
DIP; DIP-46326N; -.
IntAct; Q8CAE3; 1.
STRING; 10090.ENSMUSP00000020362; -.
iPTMnet; Q8CAE3; -.
PhosphoSitePlus; Q8CAE3; -.
PaxDb; Q8CAE3; -.
PRIDE; Q8CAE3; -.
GeneID; 16533; -.
KEGG; mmu:16533; -.
CTD; 3779; -.
MGI; MGI:1334203; Kcnmb1.
eggNOG; ENOG410IWME; Eukaryota.
eggNOG; ENOG41116AX; LUCA.
HOGENOM; HOG000290180; -.
HOVERGEN; HBG052223; -.
InParanoid; Q8CAE3; -.
KO; K04937; -.
PhylomeDB; Q8CAE3; -.
PRO; PR:Q8CAE3; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0016021; C:integral component of membrane; IDA:MGI.
GO; GO:0008076; C:voltage-gated potassium channel complex; IGI:MGI.
GO; GO:0015269; F:calcium-activated potassium channel activity; IGI:MGI.
GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0005513; P:detection of calcium ion; IBA:GO_Central.
InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
PANTHER; PTHR10258; PTHR10258; 1.
Pfam; PF03185; CaKB; 1.
PRINTS; PR01450; BKCHANNELB.
1: Evidence at protein level;
Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 191 Calcium-activated potassium channel
subunit beta-1.
/FTId=PRO_0000187047.
TOPO_DOM 1 18 Cytoplasmic. {ECO:0000255}.
TRANSMEM 19 39 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 40 155 Extracellular. {ECO:0000255}.
TRANSMEM 156 176 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 177 191 Cytoplasmic. {ECO:0000255}.
CARBOHYD 80 80 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 142 142 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 93 93 T -> A (in Ref. 1; AAD11857).
{ECO:0000305}.
CONFLICT 173 173 L -> I (in Ref. 1 and 3). {ECO:0000305}.
SEQUENCE 191 AA; 21846 MW; ABDD46528EA74AB7 CRC64;
MGKKLVMAQK RGETRALCLG VAMVVCAAIT YYVLGTTVLP LYQKSVWTQE SICHLIETNI
KDQEELEGKK VPQYPCLWVN VSAVGRWAML YHTEDTRDQN QQCSYIPRNL DNYQTALADV
KKVRANFYKH HEFYCLSAPQ VNETSVVYQR LYGPQVLLFS FFWPTFLLTG GLLLIAMVKL
NRSLSILAAQ K


Related products :

Catalog number Product name Quantity
18-783-75527 RABBIT ANTI HUMAN KCNMB3 (C-TERMINAL) - POTASSIUM LARGE CONDUCTANCE CALCIUM-ACTIVATED CHANNEL. SUBFAMILY M BETA MEMBER 3; Calcium-activated potassium channel. subfamily M subunit beta-3; Maxi K channe 0.05 mg
EIAAB37636 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,ENaCB,Epithelial Na(+) channel subunit beta,Homo sapiens,Human,Nonvoltage-gated sodium channel 1 subunit beta,SCNEB,SCNN1B
EIAAB37637 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,Epithelial Na(+) channel subunit beta,Nonvoltage-gated sodium channel 1 subunit beta,Oryctolagus cuniculus,Rabbit,SCNEB,SCNN1B
EIAAB37635 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,Epithelial Na(+) channel subunit beta,Nonvoltage-gated sodium channel 1 subunit beta,Rat,Rattus norvegicus,SCNEB,Scnn1b
EIAAB37633 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,Epithelial Na(+) channel subunit beta,Mouse,Mus musculus,Nonvoltage-gated sodium channel 1 subunit beta,SCNEB,Scnn1b
18-003-42608 Amiloride-sensitive sodium channel subunit beta - Epithelial Na+ channel subunit beta; Beta ENaC; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; Beta NaCH; ENaCB Polyclonal 0.05 mg Aff Pur
18-003-42665 Voltage-gated potassium channel subunit beta-2 - K(+) channel subunit beta-2; Kv-beta-2; HKvbeta2 Polyclonal 0.1 mg Protein A
18-003-43174 Voltage-gated potassium channel subunit beta-2 - K(+) channel subunit beta-2; Kv-beta-2; HKvbeta2 Polyclonal 0.05 mg Aff Pur
18-003-43174 Voltage-gated potassium channel subunit beta-2 - K(+) channel subunit beta-2; Kv-beta-2; HKvbeta2 Polyclonal 0.1 mg Protein A
PLCL1_HUMAN Human ELISA Kit FOR Calcium-activated potassium channel subunit beta-1 96T
E0259r Bovine ELISA Kit FOR Calcium-activated potassium channel subunit beta-1 96T
CSB-EL012078DO Dog Calcium-activated potassium channel subunit beta-1(KCNMB1) ELISA kit 96T
CSB-EL012078RA Rat Calcium-activated potassium channel subunit beta-1(KCNMB1) ELISA kit 96T
CSB-EL012079RA Rat Calcium-activated potassium channel subunit beta-2(KCNMB2) ELISA kit 96T
CDR2L_MOUSE Bovine ELISA Kit FOR Calcium-activated potassium channel subunit beta-1 96T
E0636m Mouse ELISA Kit FOR Calcium-activated potassium channel subunit beta-4 96T
P3C2G_RAT Bovine ELISA Kit FOR Calcium-activated potassium channel subunit beta-1 96T
E0521r Human ELISA Kit FOR Calcium-activated potassium channel subunit beta-1 96T
CSB-EL012082RA Rat Calcium-activated potassium channel subunit beta-4(KCNMB4) ELISA kit 96T
TMM85_BOVIN Mouse ELISA Kit FOR Calcium-activated potassium channel subunit beta-4 96T
CSB-EL012080RA Rat Calcium-activated potassium channel subunit beta-3(KCNMB3) ELISA kit 96T
18-003-42627 Voltage-gated potassium channel subunit beta-3 - K(+) channel subunit beta-3; Kv-beta-3 Polyclonal 0.1 mg Protein A
18-003-42625 Voltage-gated potassium channel subunit beta-1 - K(+) channel subunit beta-1; Kv-beta-1 Polyclonal 0.05 mg Aff Pur
CSB-EL012082MO Mouse Calcium-activated potassium channel subunit beta-4(KCNMB4) ELISA kit 96T
CSB-EL012079MO Mouse Calcium-activated potassium channel subunit beta-2(KCNMB2) ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur