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Calcium-activated potassium channel subunit beta-2 (BK channel subunit beta-2) (BKbeta2) (Hbeta2) (Calcium-activated potassium channel, subfamily M subunit beta-2) (Charybdotoxin receptor subunit beta-2) (Hbeta3) (K(VCA)beta-2) (Maxi K channel subunit beta-2) (Slo-beta-2)

 KCMB2_HUMAN             Reviewed;         235 AA.
Q9Y691;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
28-FEB-2018, entry version 134.
RecName: Full=Calcium-activated potassium channel subunit beta-2;
AltName: Full=BK channel subunit beta-2;
Short=BKbeta2;
Short=Hbeta2;
AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta-2;
AltName: Full=Charybdotoxin receptor subunit beta-2;
AltName: Full=Hbeta3;
AltName: Full=K(VCA)beta-2;
AltName: Full=Maxi K channel subunit beta-2;
AltName: Full=Slo-beta-2;
Name=KCNMB2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DOMAIN, TISSUE SPECIFICITY, AND
INTERACTION WITH KCNMA1.
TISSUE=Neuroepithelium;
PubMed=10097176; DOI=10.1073/pnas.96.7.4137;
Wallner M., Meera P., Toro L.;
"Molecular basis of fast inactivation in voltage and Ca2+-activated K+
channels: a transmembrane beta-subunit homolog.";
Proc. Natl. Acad. Sci. U.S.A. 96:4137-4142(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Ovary;
PubMed=10692449; DOI=10.1074/jbc.275.9.6453;
Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W.;
"Cloning and functional characterization of novel large conductance
calcium-activated potassium channel beta subunits, hKCNMB3 and
hKCNMB4.";
J. Biol. Chem. 275:6453-6461(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryonic testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, DOMAIN, AND TISSUE SPECIFICITY.
PubMed=10377337;
Xia X.-M., Ding J.-P., Lingle C.J.;
"Molecular basis for the inactivation of Ca2+- and voltage-dependent
BK channels in adrenal chromaffin cells and rat insulinoma tumor
cells.";
J. Neurosci. 19:5255-5264(1999).
[5]
GLYCOSYLATION.
PubMed=10792058; DOI=10.1073/pnas.100118597;
Meera P., Wallner M., Toro L.;
"A neuronal beta subunit (KCNMB4) makes the large conductance,
voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and
iberiotoxin.";
Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000).
[6]
MUTAGENESIS OF 2-PHE--TRP-4.
PubMed=12566540; DOI=10.1085/jgp.20028667;
Xia X.-M., Ding J.-P., Lingle C.J.;
"Inactivation of BK channels by the NH2 terminus of the beta2
auxiliary subunit: an essential role of a terminal peptide segment of
three hydrophobic residues.";
J. Gen. Physiol. 121:125-148(2003).
[7]
REVIEW.
PubMed=12136044; DOI=10.1152/nips.01387.2002;
Orio P., Rojas P., Ferreira G., Latorre R.;
"New disguises for an old channel: MaxiK channel beta-subunits.";
News Physiol. Sci. 17:156-161(2002).
[8]
STRUCTURE BY NMR OF 1-45.
PubMed=11517232; DOI=10.1074/jbc.M107118200;
Bentrop D., Beyermann M., Wissmann R., Fakler B.;
"NMR structure of the 'ball-and-chain' domain of KCNMB2, the beta 2-
subunit of large conductance Ca2+- and voltage-activated potassium
channels.";
J. Biol. Chem. 276:42116-42121(2001).
-!- FUNCTION: Regulatory subunit of the calcium activated potassium
KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and
gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel
diversity. Acts as a negative regulator that confers rapid and
complete inactivation of KCNMA1 channel complex. May participate
in KCNMA1 inactivation in chromaffin cells of the adrenal gland or
in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176,
ECO:0000269|PubMed:10377337}.
-!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4
molecules of KCMNB2 per KCNMA1 tetramer.
{ECO:0000269|PubMed:10097176}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in kidney, heart and brain. Highly
expressed in ovary. Expressed at low level in other tissues.
{ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337,
ECO:0000269|PubMed:10692449}.
-!- DOMAIN: The ball and chain domain mediates the inactivation of
KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and
comprises the pore-blocking ball domain (residues 1-17) and the
chain domain (residues 20-45) linking it to the transmembrane
segment. The ball domain is made up of a flexible N-terminus
anchored at a well ordered loop-helix motif. The chain domain
consists of a 4-turn helix with an unfolded linker at its C-
terminus. {ECO:0000269|PubMed:10097176,
ECO:0000269|PubMed:10377337}.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:10792058}.
-!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AF099137; AAD23380.1; -; mRNA.
EMBL; AF209747; AAF36562.1; -; mRNA.
EMBL; BC017825; AAH17825.1; -; mRNA.
CCDS; CCDS3223.1; -.
RefSeq; NP_001265840.1; NM_001278911.1.
RefSeq; NP_005823.1; NM_005832.4.
RefSeq; NP_852006.1; NM_181361.2.
RefSeq; XP_011510627.1; XM_011512325.2.
UniGene; Hs.478368; -.
PDB; 1JO6; NMR; -; A=1-45.
PDBsum; 1JO6; -.
ProteinModelPortal; Q9Y691; -.
SMR; Q9Y691; -.
BioGrid; 115536; 4.
IntAct; Q9Y691; 1.
MINT; Q9Y691; -.
STRING; 9606.ENSP00000351068; -.
DrugBank; DB01110; Miconazole.
DrugBank; DB00721; Procaine.
TCDB; 8.A.14.1.3; the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.
iPTMnet; Q9Y691; -.
PhosphoSitePlus; Q9Y691; -.
DMDM; 46396054; -.
PaxDb; Q9Y691; -.
PRIDE; Q9Y691; -.
DNASU; 10242; -.
Ensembl; ENST00000358316; ENSP00000351068; ENSG00000197584.
Ensembl; ENST00000420517; ENSP00000408252; ENSG00000197584.
Ensembl; ENST00000432997; ENSP00000407592; ENSG00000197584.
Ensembl; ENST00000452583; ENSP00000397483; ENSG00000197584.
GeneID; 10242; -.
KEGG; hsa:10242; -.
UCSC; uc003fjd.5; human.
CTD; 10242; -.
DisGeNET; 10242; -.
EuPathDB; HostDB:ENSG00000197584.11; -.
GeneCards; KCNMB2; -.
HGNC; HGNC:6286; KCNMB2.
HPA; CAB022649; -.
MIM; 605214; gene.
neXtProt; NX_Q9Y691; -.
OpenTargets; ENSG00000197584; -.
OpenTargets; ENSG00000275163; -.
PharmGKB; PA30066; -.
eggNOG; ENOG410IEU4; Eukaryota.
eggNOG; ENOG4111FIG; LUCA.
GeneTree; ENSGT00390000015997; -.
HOVERGEN; HBG052223; -.
InParanoid; Q9Y691; -.
KO; K04938; -.
OMA; KMFIWTS; -.
OrthoDB; EOG091G0MVO; -.
PhylomeDB; Q9Y691; -.
TreeFam; TF328589; -.
Reactome; R-HSA-1296052; Ca2+ activated K+ channels.
Reactome; R-HSA-418457; cGMP effects.
EvolutionaryTrace; Q9Y691; -.
GeneWiki; KCNMB2; -.
GenomeRNAi; 10242; -.
PRO; PR:Q9Y691; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000197584; -.
CleanEx; HS_KCNMB2; -.
ExpressionAtlas; Q9Y691; baseline and differential.
Genevisible; Q9Y691; HS.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0008076; C:voltage-gated potassium channel complex; IDA:UniProtKB.
GO; GO:0015269; F:calcium-activated potassium channel activity; IDA:UniProtKB.
GO; GO:0008200; F:ion channel inhibitor activity; TAS:ProtInc.
GO; GO:0015459; F:potassium channel regulator activity; TAS:ProtInc.
GO; GO:0001508; P:action potential; IDA:UniProtKB.
GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
GO; GO:0005513; P:detection of calcium ion; IDA:UniProtKB.
GO; GO:0019228; P:neuronal action potential; IDA:UniProtKB.
GO; GO:0006813; P:potassium ion transport; IDA:UniProtKB.
GO; GO:0019229; P:regulation of vasoconstriction; TAS:UniProtKB.
Gene3D; 4.10.81.20; -; 1.
InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
InterPro; IPR037096; KCNMB2_ball/chain_dom_sf.
InterPro; IPR015382; KCNMB2_ball_chain_dom.
PANTHER; PTHR10258; PTHR10258; 1.
Pfam; PF03185; CaKB; 1.
Pfam; PF09303; KcnmB2_inactiv; 1.
PRINTS; PR01450; BKCHANNELB.
1: Evidence at protein level;
3D-structure; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 235 Calcium-activated potassium channel
subunit beta-2.
/FTId=PRO_0000187051.
TOPO_DOM 1 46 Cytoplasmic. {ECO:0000255}.
TRANSMEM 47 67 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 68 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 215 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 216 235 Cytoplasmic. {ECO:0000255}.
REGION 1 45 Ball and chain.
CARBOHYD 88 88 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 96 96 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 119 119 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
MUTAGEN 2 4 FIW->GGG: Abolishes inactivation of
KCNMA1 channel.
{ECO:0000269|PubMed:12566540}.
STRAND 12 15 {ECO:0000244|PDB:1JO6}.
HELIX 22 29 {ECO:0000244|PDB:1JO6}.
TURN 30 32 {ECO:0000244|PDB:1JO6}.
STRAND 33 35 {ECO:0000244|PDB:1JO6}.
SEQUENCE 235 AA; 27130 MW; 5752021DF27D8CF5 CRC64;
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL GLAMMVCSIM
MYFLLGITLL RSYMQSVWTE ESQCTLLNAS ITETFNCSFS CGPDCWKLSQ YPCLQVYVNL
TSSGEKLLLY HTEETIKINQ KCSYIPKCGK NFEESMSLVN VVMENFRKYQ HFSCYSDPEG
NQKSVILTKL YSSNVLFHSL FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR


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